Major interaction on record — check this product against your medications before combining. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Test PSI Ingredients & Drug Interactions

by Achievements Through Science (ATS) Labs

Test PSI label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Test PSI against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Test PSI is a dietary supplement by Achievements Through Science (ATS) Labs with 4 active ingredients. Its ingredients are commonly taken for boosting testosterone, improving libido and sexual function, athletic performance and muscle building.Based on those ingredients, 193 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Mucuna pruriens. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Test PSI by Achievements Through Science (ATS) Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Test PSI by Achievements Through Science (ATS) Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Test PSI by Achievements Through Science (ATS) Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Testosterone Support Matrix” is a proprietary blend — the label gives one combined amount (2,280 mg) without saying how much of each component you get.

Test PSI is a 4-ingredient capsule. The active ingredients are 4'-Methoxy-5,7-Dihydroxyflavone, D-Aspartic Acid, Testosterone Support Matrix (a blend of other components), Fadogia agrestis Stem Extract, and Mucuna pruriens — the latter a legume seed extract used in traditional medicine.

The capsule itself is filled with gelatin, rice flour, and cellulose as inactive fillers and binders.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: lean muscle gains and athletic performance.
  • We looked for evidence on: Athletic performance, muscle strength, body composition, exercise performance.
  • The closest evidence on file: Fadogia Agrestis is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).

The evidence for Test PSI's ingredients is limited. Fadogia agrestis has been studied for athletic performance, erectile dysfunction, and malaria treatment, but we don't have reliable evidence to rate how well it works for any of these.

Mucuna pruriens has been evaluated for anxiety, skin redness (erythema), high prolactin levels, muscle pain, Parkinson disease, and rheumatoid arthritis — again, insufficient reliable evidence exists to rate its effectiveness. The two other active ingredients have no effectiveness ratings in our data.

The evidence, ingredient by ingredient Fadogia Agrestis Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Fadogia agrestis comes with a caution: human safety data are lacking, and animal studies hint at possible harm to the testicles, liver, and kidneys. Avoid it during pregnancy and breastfeeding, since no safety data exist.

Mucuna pruriens contains L-dopa (levodopa), an active drug-like compound, so it requires careful use and professional guidance. It should be avoided in pregnancy due to its dopamine effects, and avoided while breastfeeding because L-dopa can lower prolactin and reduce milk supply.

Oral side effects from Mucuna pruriens are generally rare but may include diarrhea, flatulence, mucosal irritation, dry mouth, nausea, vomiting, abdominal bloating, and headaches. Insomnia was reported in about 3% of people taking certain Mucuna seed extracts in clinical research.

Side effects, ingredient by ingredient Fadogia Agrestis Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Cowhage.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; Parkinson's medications.
  • For scale: 193 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications before taking Test PSI if you use monoamine oxidase inhibitors (MAOIs), methyldopa, levodopa, or cyclopropane/halogenated anesthetics (Major interactions). Also double-check if you take diabetes medications, antipsychotics, tricyclic antidepressants, or guanethidine (Moderate interactions).

These effects stem from the Mucuna pruriens ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Test PSI is intended to support testosterone and athletic function, but effectiveness evidence is insufficient for both main ingredients. If you take any blood pressure medication, antidepressant (especially an MAOI), diabetes drug, antipsychotic, or Parkinson's medication, you need to check your exact drugs with us before starting — the Mucuna pruriens content poses real interaction risks.

Talk with your pharmacist or doctor, particularly if you're pregnant, breastfeeding, or have liver or kidney concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Test PSI, straight from the product label.

Brand Achievements Through Science (ATS) Labs
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 297212
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Test PSI by Achievements Through Science (ATS) Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
40
IngredientAmount% DV
4'-Methoxy-5,7-Dihydroxyflavone0 NP--
D-Aspartic Acid0 NP--
Testosterone Support Matrix2280 mg--
Fadogia agrestis Stem Extract0 NP--
Mucuna pruriens0 NP--

Other ingredients: Gelatin, Rice Flour, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Lean muscle gains

General Statements

Dry

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Test PSI by Achievements Through Science (ATS) Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Test PSI label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Test PSI by Achievements Through Science (ATS) Labs

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Testosterone Support Matrix

2280 mg per serving

Other (inactive) ingredients: Gelatin, Rice Flour, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Test PSI by Achievements Through Science (ATS) Labs Drug Interactions

Want to check YOUR meds against Test PSI?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
193Drugs
17 Major 176 Moderate

Ingredients driving the most interactions

Mucuna pruriens 193

Individual Drug Interactions

The ingredients in Test PSI interact with 193 drugs. Click any drug to see the details.

1 of the 4 ingredients in Test PSI interact with drugs. Each result below shows which ingredient is responsible. Mucuna pruriens

Each ingredient & the kinds of drugs it affects

For each ingredient in Test PSI with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mucuna pruriens8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna pruriens full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Test PSI, from the product label.

Achievements Through Science (ATS) Labs

See all Achievements Through Science (ATS) Labs products
Name
Achievements Through Science Labs
Pharmacist Counseling Corner

Test PSI by Achievements Through Science (ATS) Labs: Common Questions

Does Test PSI by Achievements Through Science (ATS) Labs interact with any medications?
Yes. Based on its ingredients, Test PSI has a known interaction with 193 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Test PSI contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Mucuna pruriens and why is it in this product?
Mucuna pruriens is a legume seed that contains levodopa, a compound that affects dopamine in the brain. It's included here as part of a testosterone support formula, though reliable evidence for how well it works for that purpose is lacking.
Can I take this if I'm pregnant or breastfeeding?
No. Fadogia agrestis has no safety data and should be avoided during pregnancy and breastfeeding. Mucuna pruriens should also be avoided — it affects dopamine and hormones in ways that aren't safe in pregnancy, and it can reduce milk supply while breastfeeding. Talk with your doctor before considering any supplement during these times.
What side effects might I experience?
Mucuna pruriens may cause diarrhea, flatulence, dry mouth, nausea, vomiting, abdominal bloating, or headaches. Insomnia was reported in about 3% of people in clinical trials. Fadogia agrestis side effects aren't well documented because safety data are limited.
Is this product effective for boosting testosterone or athletic performance?
We don't have reliable evidence to say. Both Fadogia agrestis and Mucuna pruriens lack sufficient clinical data to rate how well they work for these goals.
Why does this product have so many medication interactions?
Mucuna pruriens contains levodopa, an active drug-like compound. Levodopa interacts with blood pressure medications, antidepressants, diabetes drugs, antipsychotics, and certain anesthetics in ways that can be harmful — that's why you need to check your exact prescriptions before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Test PSI is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Test PSI label
Go deeper

The Full Monographs Behind Test PSI’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fadogia Agrestis

Fadogia agrestis is a West African shrub marketed as a testosterone booster, but human evidence is essentially nonexistent and what we know comes mostly from a few small rat studies. Animal...

Read the full Fadogia Agrestis monograph → Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

Test PSI's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fadogia Agrestis 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Fadogia Agrestis monograph →

Cowhage 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
  5. Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
  7. Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
  8. Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
  9. Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
  10. Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
  11. Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
  12. Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed

See these in context on the Cowhage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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