Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Total Calm with Relora Ingredients & Drug Interactions

by Solaray

Total Calm with Relora label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Total Calm with Relora against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Total Calm with Relora is a dietary supplement by Solaray with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 565 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Total Calm with Relora by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Total Calm with Relora by Solaray — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Total Calm with Relora by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Total Calm with Relora contains two active ingredients. L-theanine is an amino acid that's thought to promote relaxation without causing drowsiness.

The product also contains Relora, but we don't have detailed information on file about that ingredient's role. The capsule also holds several inactive ingredients — modified food starch, modified corn starch, cellulose, silica, and magnesium stearate — which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Theanine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Mood support.
  • We looked for evidence on: Depression, Generalized anxiety disorder (GAD), Stress, Anxiety, Emotional wellness.
  • The closest evidence on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Depression, Stress.

For L-theanine, the evidence shows it's possibly effective for cognitive function, meaning some studies support it but the proof isn't airtight yet. For other uses — age-related cognitive decline, Alzheimer's disease, generalized anxiety, and OCD — there isn't enough reliable evidence in our data to say whether it works.

We also have no effectiveness information on file for Relora.

The evidence, ingredient by ingredient Theanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated in healthy adults when used for short periods, but we don't have good long-term safety data. Some people report headaches, drowsiness, more sleep, or more vivid dreams.

One child had a mild facial tic after starting L-theanine, but it went away when she stopped; she'd had tics before, so the link wasn't clear. The safety data advises against using L-theanine during pregnancy and while breastfeeding because there isn't enough information to know it's safe.

Talk with your doctor or pharmacist for personalized advice if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Theanine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Theanine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 565 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check if you're on blood pressure medications (the most serious concern here) or any sedating drugs like sleep aids or anti-anxiety medication. No interactions are documented for Relora — we simply don't have the data to check it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Total Calm with Relora may be worth considering if you're looking for a relaxation support and your medications don't interact with L-theanine. If you take blood pressure medicine, any sedating drug, or anything serotonin-related, check your exact medications with the tool on this page first.

Pregnant or nursing? You'll want to talk with your pharmacist or doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Total Calm with Relora, straight from the product label.

Brand Solaray
Barcode (UPC) 076280088618
Net contents 30 VegCap(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 338757
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Total Calm with Relora by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 VegCap(s)
Maximum serving Sizes:
2 VegCap(s)
Servings per container
15
UPC/BARCODE
076280088618
IngredientAmount% DV
L-Theanine50 mg--
Relora750 mg--

Other ingredients: Food Starch, Modified, Corn Starch, Modified, Cellulose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973

Relora is a registered trademark of Lonza Consumer Health, Inc.

Formulation

Mood support

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Do not take if pregnant or lactating. Do not take if currently taking any prescription medication or receiving medical treatment without consulting your physician.

Directions: Use only as directed.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 2 VegCaps daily with a meal or a glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

100% PCR Bottles

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Total Calm with Relora by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Total Calm with Relora label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Total Calm with Relora by Solaray

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 VegCap(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
50 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Relora

750 mg per serving Form: Magnolia officinalis bark extract, Phellodendron amurense bark extract

Other (inactive) ingredients: Food Starch, Modified, Corn Starch, Modified, Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Total Calm with Relora by Solaray Drug Interactions

Want to check YOUR meds against Total Calm with Relora?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
565Drugs
172 Moderate 393 Minor

Ingredients driving the most interactions

L-Theanine 565

Individual Drug Interactions

The ingredients in Total Calm with Relora interact with 565 drugs. Click any drug to see the details.

1 of the 2 ingredients in Total Calm with Relora interact with drugs. Each result below shows which ingredient is responsible. L-Theanine

Each ingredient & the kinds of drugs it affects

For each ingredient in Total Calm with Relora with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Total Calm with Relora, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

Total Calm with Relora by Solaray: Common Questions

Does Total Calm with Relora by Solaray interact with any medications?
Yes. Based on its ingredients, Total Calm with Relora has a known interaction with 565 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Total Calm with Relora contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against it — there isn't enough information to know L-theanine is safe during pregnancy or while nursing. Talk with your doctor or pharmacist for personalized advice about what's right for you.
Will this make me drowsy?
It's designed to promote calm, and some people do report drowsiness after taking L-theanine. Others report more sleep or more vivid dreams. You might experience headaches instead. Individual responses vary.
Does L-theanine actually work for anxiety or cognitive function?
For cognitive function, the evidence is possibly effective — some studies show benefit. For anxiety disorders like generalized anxiety or OCD, there isn't enough reliable evidence in our data to say it works. You might want to talk with your pharmacist about what research supports.
How long is it safe to use L-theanine?
L-theanine is generally well tolerated in healthy adults for short-term use, but we don't have good safety data for long-term use. If you're planning to take it for more than a few weeks, check with your pharmacist.
What's Relora, and what does it do in this product?
Relora is the second active ingredient in this product, but we don't have detailed information on file about what it is or how it works. Your pharmacist can tell you more about it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Total Calm with Relora is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Total Calm with Relora label
Go deeper

The Full Monographs Behind Total Calm with Relora’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph →
Sources

Sources & How We Checked

Total Calm with Relora's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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