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Dietary supplement

Tribulus Extract 750 mg Ingredients & Drug Interactions

by Source Naturals

Tribulus Extract 750 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Extract 750 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Extract 750 mg is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus Extract 750 mg by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Extract 750 mg by Source Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus Extract 750 mg by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tribulus fruit extract at 750 mg per tablet. Tribulus is a plant whose fruit has been studied for sexual function and athletic performance.

The tablet also includes several inactive ingredients — acacia, stearic acid, silica, modified cellulose gum, and magnesium stearate — which are binders and fillers that help form and stabilize the pill.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports reproductive function.
  • We looked for evidence on: Erectile dysfunction (ED), Male infertility, Premature ejaculation, Sexual dysfunction, Menopausal symptoms, Polycystic ovary syndrome (PCOS) — and 3 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Menopausal symptoms, Polycystic ovary syndrome (PCOS), Premature ejaculation, and more.

Tribulus fruit extract is rated possibly effective for sexual dysfunction. For athletic performance, the evidence is rated possibly ineffective.

For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to rate it either way. If you're considering this supplement for sexual health, the data suggest it may help — but talk it over with your doctor to see whether it's right for your situation.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is often well tolerated in the short term for healthy adults, but long-term safety data are limited and quality varies between products. Serious side effects are rare but have been reported, including liver or kidney injury, seizures, and in one case a prolonged painful erection with sexual dysfunction.

More commonly, some people experience stomach upset — abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation — though in one study these complaints occurred at similar rates in both tribulus and placebo groups. The safety data advise against use during pregnancy because tribulus may affect hormones and safety hasn't been established.

Avoid it while breastfeeding as well, since reliable safety information isn't available.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before you take it if you're on blood pressure drugs (antihypertensives) or diabetes medication — tribulus may boost their effects and lower your blood pressure or blood sugar too far. If you take lithium for mood, tribulus could raise its levels in your blood.

These are Moderate-severity concerns, so confirm with your doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus extract may help with sexual dysfunction, but it can affect your blood pressure, blood sugar, and lithium levels — so it's not a grab-and-go choice if you take medications. Short-term use is generally well tolerated, though long-term safety data are thin.

Talk with your doctor or pharmacist before starting, especially if you're on blood pressure meds, diabetes medication, or lithium.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Extract 750 mg, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078014607
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2018
DSLD ID 78129
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Extract 750 mg by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
UPC/BARCODE
021078014607
IngredientAmount% DV
Tribulus fruit extract750 mg--

Other ingredients: Acacia, Stearic Acid, Silica, modified Cellulose Gum, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

General Statements

Supports reproductive function

Tribulus terrestris is a tropical vine common in sandy soil throughout India, Pakistan, and Sri Lanka.

This south Asian herb is popular for its potential role in supporting reproductive function. Tribulus extract can be used by both men and women.

Formula

Source Naturals Tribulus Extract contains over 40% total saponins, the active components.

Tribulus extract can be used by both men and women.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 to 2 tablets daily.

Precautions

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Caution: If you are pregnant, may become pregnant, breastfeeding, or have a serious medical condition, consult your physician before using this product.

Formulation

Suitable for vegetarians.

Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

SN1460 REV F132

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Extract 750 mg by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Extract 750 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Extract 750 mg by Source Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Tribulus fruit extract

Interacts with
259 drugs
750 mg per serving Form: total Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus fruit extract monograph & interactions

Other (inactive) ingredients: Acacia, Stearic Acid, Silica, Modified Cellulose Gum, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Extract 750 mg by Source Naturals Drug Interactions

Want to check YOUR meds against Tribulus Extract 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus fruit extract 259

Individual Drug Interactions

The ingredients in Tribulus Extract 750 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Extract 750 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Extract 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus fruit extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Extract 750 mg, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

Tribulus Extract 750 mg by Source Naturals: Common Questions

Does Tribulus Extract 750 mg by Source Naturals interact with any medications?
Yes. Based on its ingredients, Tribulus Extract 750 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Extract 750 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with sexual performance?
Tribulus is rated possibly effective for sexual dysfunction, meaning the research suggests it may help — but results aren't guaranteed or dramatic. Your own response may differ, and it's worth discussing with your doctor whether it's right for you.
Can I take this if I'm trying to get pregnant?
No — the safety data advise against tribulus during pregnancy because it may affect hormones and safety hasn't been established. Talk with your doctor about what's safe for you at this time.
What are the most common side effects?
Stomach upset — including abdominal pain, nausea, vomiting, diarrhea, or constipation — is the main complaint. In one study, though, these side effects occurred at similar rates in both tribulus and placebo groups, so they're not guaranteed.
Is this safe for long-term use?
Tribulus is generally well tolerated in the short term, but long-term safety data are limited. Quality and purity also vary between products. If you're thinking of taking it regularly, run it by your doctor or pharmacist first.
What is tribulus fruit extract and what does it do?
Tribulus is a plant whose fruit extract has been studied for sexual health and athletic performance. It may lower blood pressure and blood sugar, which is why it can interact with certain medications.
Can I breastfeed while taking this?
No — there isn't enough reliable safety information about tribulus in breastfeeding, so it's best to avoid it. Talk with your doctor about what's safe while nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Extract 750 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Extract 750 mg label
Go deeper

The Full Monographs Behind Tribulus Extract 750 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Extract 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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