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Dietary supplement

Tribulus Maximus 250 Ingredients & Drug Interactions

by LifeLink

Tribulus Maximus 250 label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Maximus 250 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Maximus 250 is a dietary supplement by LifeLink with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus Maximus 250 by LifeLink

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Maximus 250 by LifeLink — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus Maximus 250 by LifeLink

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tribulus Maximus 250 contains one active ingredient: tribulus terrestris (also called puncture vine), a plant extract traditionally used for sexual function and athletic performance. The tablet also includes inactive ingredients — dicalcium phosphate, hydroxypropylcellulose, stearic acid, croscarmelose sodium, and magnesium stearate — which are fillers and binders that help form and hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: reproductive health and fertility support.
  • We looked for evidence on: Male infertility, Sexual dysfunction, Erectile dysfunction (ED), Premature ejaculation, Female infertility, Reproductive function.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Premature ejaculation, Male infertility.

Tribulus terrestris is possibly effective for sexual dysfunction based on clinical evidence in our data. For athletic performance, the evidence suggests it's possibly ineffective — so if that's your goal, the research doesn't support it.

As for benign prostatic hyperplasia (BPH), there isn't enough reliable evidence to rate whether it works for that condition.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is often well tolerated in the short term for healthy adults, but long-term safety data and product quality information are limited. The most common side effects are gastrointestinal — stomach pain, cramping, nausea, vomiting, diarrhea, or constipation — though in one study these occurred at similar rates in people taking tribulus and those taking placebo.

Serious adverse effects are rare but have been reported, including liver or kidney injury and seizures. During pregnancy, tribulus is rated possibly unsafe because it may affect hormones and safety hasn't been established — the safety data advises against it.

While breastfeeding, there isn't enough reliable information to know whether it's safe, so it's best to avoid it. If you're pregnant or nursing, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Tribulus Maximus 250, double-check your medications against these: blood pressure medications (antihypertensives), diabetes medications (antidiabetes drugs), and lithium. All three carry moderate-severity interaction risks.

Talk with your doctor or pharmacist about whether this product is safe for you to use alongside what you're currently taking.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual dysfunction, but it comes with moderate interaction risks if you take blood pressure medication, diabetes medication, or lithium. If you're on any of those, check with your doctor or pharmacist before starting.

Avoid it during pregnancy and while breastfeeding. Long-term safety data are limited, so it's mainly for short-term use in otherwise healthy adults.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 24, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Maximus 250, straight from the product label.

Brand LifeLink
Barcode (UPC) 639793204014
Net contents 90 Tablet(s); 250 mg
Market status On market
Date entered into DSLD Aug 24, 2012
DSLD ID 11752
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Maximus 250 by LifeLink, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
UPC/BARCODE
639793204014
IngredientAmount% DV
Tribulus terrestris250 mg--

Other ingredients: Dicalcium Phosphate, Hydroxypropylcellulose, Stearic Acid, Croscarmelose Sodium, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 1 to 4 tablets 3 times per day.

General Statements

Tribulus terrestris L. has been used as a safe non-hormonal treatment for infertility and other reproductive disorders.

Formula

Tribulus terrestris L.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Maximus 250 by LifeLink label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Maximus 250 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Maximus 250 by LifeLink

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Tribulus terrestris

Interacts with
259 drugs
250 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Hydroxypropylcellulose, Stearic Acid, Croscarmelose Sodium, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Maximus 250 by LifeLink Drug Interactions

Want to check YOUR meds against Tribulus Maximus 250?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris 259

Individual Drug Interactions

The ingredients in Tribulus Maximus 250 interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Maximus 250 interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Maximus 250 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Maximus 250, from the product label.

LifeLink

See all LifeLink products
Name
Life Link
City
Grover Beach
State
CA
ZipCode
93433
Web Address
http://www.lifelinknet.com
Pharmacist Counseling Corner

Tribulus Maximus 250 by LifeLink: Common Questions

Does Tribulus Maximus 250 by LifeLink interact with any medications?
Yes. Based on its ingredients, Tribulus Maximus 250 has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Maximus 250 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does tribulus actually work for sexual dysfunction?
The evidence suggests it's possibly effective for sexual dysfunction, so there is clinical support for it — though results may vary from person to person. Long-term safety data are limited, and it's mainly studied for short-term use.
Can I take this if I'm pregnant or breastfeeding?
No — during pregnancy, tribulus is rated possibly unsafe because it may affect hormones and safety hasn't been established. While breastfeeding, there isn't enough reliable safety information. Talk with your doctor or pharmacist about whether this product is right for you.
What are the most common side effects?
Stomach upset — including abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation — is the main concern. In one study, however, these side effects happened at similar rates in people taking tribulus and those on placebo, so they may not all be directly caused by the product.
Will this help my athletic performance?
The evidence suggests tribulus is possibly ineffective for athletic performance, so the research doesn't support using it for that goal.
What inactive ingredients are in this tablet?
The inactive ingredients are dicalcium phosphate, hydroxypropylcellulose, stearic acid, croscarmelose sodium, and magnesium stearate — fillers and binders that help form the tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Maximus 250 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Maximus 250 label
Go deeper

The Full Monographs Behind Tribulus Maximus 250’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Maximus 250's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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