Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Ultimate Strength Probiotic Ingredients & Drug Interactions

by Culturelle

Ultimate Strength Probiotic label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate Strength Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Ultimate Strength Probiotic is a dietary supplement by Culturelle with 2 active ingredients. Its ingredients are commonly taken for constipation and regularity, prebiotic gut health, blood sugar support.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Inulin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate Strength Probiotic by Culturelle

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate Strength Probiotic by Culturelle — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultimate Strength Probiotic by Culturelle

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Culturelle Ultimate Strength Probiotic has 2 active ingredients: inulin and Lactobacillus rhamnosus GG. Inulin is a prebiotic fiber — food for the beneficial bacteria in your gut — and may help with blood sugar control and digestive function.

Lactobacillus rhamnosus GG is a probiotic strain (live beneficial bacteria) commonly used to support gut and immune health. The capsule also contains inactive ingredients: hydroxypropyl methylcellulose, vegetable magnesium stearate, and colors.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive support and microbiome balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Gut dysbiosis, Digestive imbalance, Microbiome restoration.
  • The strongest evidence on file: Inulin is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Inulin is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea.

Inulin shows possibly effective evidence for obesity, constipation, and diabetes. For nonalcoholic fatty liver disease (NAFLD) and iron deficiency anemia, the evidence we hold is insufficient to rate it.

Data on the effectiveness of Lactobacillus rhamnosus GG for specific conditions isn't included in the facts we have on file.

The evidence, ingredient by ingredient Inulin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Inulin is generally well tolerated in food amounts, but concentrated supplement doses aren't well studied, so caution is warranted. Most people experience bloating, flatulence, diarrhea, constipation, or stomach cramps — especially at doses above 30 grams.

Rarely, anaphylaxis (a severe allergic reaction) has occurred with foods high in inulin. Inulin is rated likely safe during pregnancy and lactation.

We hold no safety data for Lactobacillus rhamnosus GG on file.

Side effects, ingredient by ingredient Inulin

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Inulin.
  • The most serious interaction on file is rated Minor.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (like insulin, metformin, or glipizide), double-check this product first — inulin may increase the risk of low blood sugar. We couldn't check Lactobacillus rhamnosus GG against any medications, so use the search tool for your complete medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This probiotic may be worth considering if you're interested in digestive or blood sugar support, though the evidence for inulin is still developing. If you take medications for diabetes, blood sugar, or anything else, check your specific drugs with the tool on this page before starting — especially if you're on antidiabetes medication.

Gas and bloating are common, particularly at higher doses. Chat with your pharmacist if you're unsure whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Strength Probiotic, straight from the product label.

Brand Culturelle
Barcode (UPC) 049100400518
Net contents 30 Once Daily Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 250886
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Strength Probiotic by Culturelle, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
049100400518
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 Gram(s)--
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Inulin200 mg--
Lactobacillus rhamnosus GG83 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Vegetable Magnesium Stearate, Colors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Ultimate digestive support from Culturelle

Powerful formula with 2X more good bacteria Keeps your digestive system balanced Restores balance even during travel or antibiotic use

Allergy friendly Free from Milk - Wheat - Eggs Tree Nuts - Peanuts

Most clinically researched strain in the world Based on the number of Lactobacillus rhamnosus GG studies, as of January 2019. Guaranteed purity & potency Guaranteed potency through date on box when stored as directed.

Dairy - Gluten - Soy - Free Meets the FDA's guidelines for gluten-free.

Try me with antibiotics Powerful formula balances your digestive system Works naturally with your body to restore balance even when taking antibiotics

Formula

Support your body with 2X the good bacteria in Culturelle Ultimate Strength. Formulated with 20 billion CFUs, this powerful formula can restore balance every day, especially during high stressors like antibiotic use which kills both good & bad bacteria, or during travel. Versus 10 billion CFUs in Culturelle Digestive Daily Probiotic capsules.

Not a reduced calorie food.

LGG naturally sourced LGG

General Statements

Unleash the power of your microbiome! Your gut microbiome helps support an overall healthy you because it's linked to your digestive health, cognition, mood, nutrition, and immune system. You can trust your gut daily to Culturelle.

Scan to learn more

Our brand values We're on a mission to inspire better health & wellness for you and your family. We believe in integrity, so we hold ourselves to the highest standards of truth. We believe in the natural power of your body's microbiome, & in scientific research & products that will unlock its full potential. We believe in uncompromising quality, safety & proven efficacy. We believe in empowering you to embrace every day with confidence.

The Culturelle difference Excludes gummy formulas.

New name Same extra strength formula

The most trusted probiotic brand Based on the 2019 BrandSpark American Shopper Study. Culturelle Probiotics

Storage

Storage instructions: Store Culturelle in a cool, dry place away from direct sunlight.

Precautions

Tamper evident: Product is sealed within blisters. Do not use if any part of the blister is torn, open or damaged.

Keep out of reach of children.

Inform a healthcare professional before starting any dietary supplement, particularly if there is a known immune-compromised condition. When first taking a probiotic, your gut microbiome adjusts. You may experience minor bloating, gas or intestinal gurgling which should subside with continued use. Consult your healthcare professional if symptoms continue after two weeks. For questions, concerns or to report an adverse event please call (800) 722-3476.

Brand IP Statement(s)

Culturelle is a trademark of DSM. LGG & LGG logo are trademarks of Chr. Hansen A/S.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions for age 12+ years: Take one capsule daily. Continued use is suggested. When traveling, take one capsule daily before and during the trip. During antibiotic use, take one capsule daily and continue for 10 days after completion of antibiotics.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate Strength Probiotic by Culturelle label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate Strength Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate Strength Probiotic by Culturelle

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Inulin

Interacts with
86 drugs
200 mg per serving Form: Chicory root extract

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements an...

Inulin monograph & interactions

Lactobacillus rhamnosus GG

83 mg per serving

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Vegetable Magnesium Stearate, Colors. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Strength Probiotic by Culturelle Drug Interactions

Want to check YOUR meds against Ultimate Strength Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Minor

Ingredients driving the most interactions

Inulin 86

Individual Drug Interactions

The ingredients in Ultimate Strength Probiotic interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Ultimate Strength Probiotic interact with drugs. Each result below shows which ingredient is responsible. Inulin

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Strength Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultimate Strength Probiotic, from the product label.

Culturelle

Name
i-Health, Inc.
Street Address
55 Sebethe Drive
City
Cromwell
State
CT
ZipCode
06416
Phone Number
(800) 722-3476
Web Address
www.culturelle.com
Pharmacist Counseling Corner

Ultimate Strength Probiotic by Culturelle: Common Questions

Does Ultimate Strength Probiotic by Culturelle interact with any medications?
Yes. Based on its ingredients, Ultimate Strength Probiotic has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Strength Probiotic contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic make me feel bloated?
It's a real possibility. Inulin commonly causes gas, bloating, and stomach cramps — especially if you take higher doses or jump to a large amount right away. Start low and go slow, and talk to your pharmacist if it persists.
Does this help with constipation?
Inulin shows possibly effective evidence for constipation, though results vary. Keep in mind it can also cause diarrhea in some people, so if you're prone to loose stools, monitor how you respond.
Is it safe to take while pregnant or breastfeeding?
Inulin is rated likely safe in pregnancy and lactation. We don't have safety data on file for the probiotic strain (Lactobacillus rhamnosus GG), so chat with your doctor or midwife if you want personalized guidance.
Does it help with blood sugar control?
Inulin shows possibly effective evidence for diabetes, and some research suggests it may improve blood sugar control. However, if you take diabetes medication, that's exactly why you need to check with your pharmacist first — there's a risk of low blood sugar.
What's the difference between the inulin and the probiotic in here?
Inulin is a prebiotic — a type of fiber that feeds the good bacteria already in your gut. Lactobacillus rhamnosus GG is the probiotic strain itself — actual live beneficial bacteria. Together they're meant to support your gut health.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultimate Strength Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Strength Probiotic label
Go deeper

The Full Monographs Behind Ultimate Strength Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph →
Sources

Sources & How We Checked

Ultimate Strength Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inulin 17 references
  1. Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. PubMed
  2. Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  5. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. PubMed
  6. Guess ND, Dornhorst A, Oliver N, Frost GS. A randomised crossover trial: the effect of inulin on glucose homeostasis in subtypes of prediabetes. Ann Nutr Metab 2016;68(1):26-34. PubMed
  7. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 2011;62(2):164-70. PubMed
  8. Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL. Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics. Carbohydr Polym 2015;130:405-19. PubMed
  9. Slavin J, Feirtag J. Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct. 2011;2(1):72-7. PubMed
  10. Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 2017;68(1):82-89. PubMed
  11. Smiljanec K, Mitchell CM, Privitera OF, Neilson AP, Davy KP, Davy BM. Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial. Nutr Health. 2017;23 PubMed
  12. Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res PubMed
  13. Rao M, Gao C, Xu L, et al. Effect of inulin-type carbohydrates on insulin resistance in patients with type 2 diabetes and obesity: a systematic review and meta-analysis. J Diabetes Res. 2019;2019:5101423. PubMed
  14. Mitchell CM, Davy BM, Ponder MA, et al. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients 2021;13(9):3235. PubMed
  15. Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. PubMed
  16. Ziaei R, Shahshahan Z, Ghasemi-Tehrani H, Heidari Z, Ghiasvand R. Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized,
  17. Risso D, Kaczmarczyk M, Laurie I, et al. Moderate intakes of soluble corn fibre or inulin do not cause gastrointestinal discomfort and are well tolerated in healthy children. Int J Food Sci Nutr 2022;73(8):1104-1115. PubMed

See these in context on the Inulin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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