Major interaction on record — check this product against your medications before combining. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Ultra Super Fuel Mixed Berry Flavored Ingredients & Drug Interactions

by Frog Fuel

Ultra Super Fuel Mixed Berry Flavored label
See full label image
Liquid Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Super Fuel Mixed Berry Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Ultra Super Fuel Mixed Berry Flavored is a dietary supplement by Frog Fuel with 6 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 310 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Calcium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ultra Super Fuel Mixed Berry Flavored by Frog Fuel

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Super Fuel Mixed Berry Flavored by Frog Fuel — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ultra Super Fuel Mixed Berry Flavored by Frog Fuel

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.

Frog Fuel Ultra Super Fuel Mixed Berry is a liquid with four active ingredients: sodium, potassium, calcium, and chloride. We hold no interaction data for chloride.

The product also contains several inactive ingredients (water, enzyme-hydrolyzed collagen protein, maltodextrin, dextrose, beta-alanine, citrulline malate, citric acid, taurine, potassium chloride, flavor, calcium chloride, benzoate of soda, potassium sorbate, sodium chloride, and sucralose) that serve as fillers, binders, and flavoring.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Power, speed, and endurance support.
  • We looked for evidence on: Exercise-induced muscle damage, Athletic performance, Muscle strength, Muscle recovery.
  • The closest evidence on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage (Natural Medicines).

Calcium in this product is backed by solid evidence: it's effective for kidney failure, dyspepsia (indigestion), low blood calcium (hypocalcemia), and high potassium (hyperkalemia), and likely effective for osteoporosis. Sodium shows likely effectiveness for cystic fibrosis and possibly effective use for reducing a kidney-damaging side effect of the antibiotic amphotericin B, though the evidence for treating bipolar disorder and congestive heart failure is insufficient to rate.

We hold no effectiveness ratings for potassium or chloride.

The evidence, ingredient by ingredient Sodium Potassium Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated at normal dietary amounts up to the Chronic Disease Risk Reduction level of 2.3 grams daily, but excess sodium is linked to high blood pressure, heart strain, kidney disease, and possibly gastric cancer risk. Potassium from food is fine, but supplements can cause dangerously high blood levels, especially in people with kidney disease—common side effects are abdominal pain, belching, diarrhea, nausea, and vomiting; serious effects (rare) include irregular heartbeat and cardiac arrest.

Calcium is generally well tolerated at recommended doses, with common side effects being belching, constipation, diarrhea, and stomach upset. High calcium doses raise theoretical concerns about kidney stones and may increase prostate or cardiovascular disease risk.

Pregnancy and lactation data shows sodium is likely safe but possibly unsafe, potassium is likely safe, and calcium is likely safe but possibly unsafe—talk to your doctor or pharmacist about your individual situation.

Side effects, ingredient by ingredient Sodium Potassium Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Calcium, Potassium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 310 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir), blood pressure medications including ACE inhibitors and ARBs, potassium-sparing diuretics, corticosteroids, lithium, heart rhythm drugs like sotalol, thyroid medication (levothyroxine), and antibiotics including ceftriaxone. The calcium content poses major risks with dolutegravir, elvitegravir, and IV ceftriaxone; spacing doses carefully or avoiding the combination may be necessary.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Frog Fuel Ultra Super Fuel Mixed Berry is designed as a supplement drink with electrolytes and amino acids, but its sodium, potassium, and especially calcium content creates real medication interactions, particularly with HIV antivirals, blood pressure drugs, and thyroid medication. If you take any prescription medications—especially blood pressure drugs, heart medications, lithium, HIV treatments, antibiotics, or thyroid medication—check them against the tool on this page before you start.

Talk to your pharmacist about whether this product fits your individual health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Super Fuel Mixed Berry Flavored, straight from the product label.

Brand Frog Fuel
Barcode (UPC) 851010004089
Net contents 29 Oz(s); 864 mL
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 174981
Product type Amino Acid/protein
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Super Fuel Mixed Berry Flavored by Frog Fuel, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
36 mL
Maximum serving Sizes:
36 mL
Servings per container
24
UPC/BARCODE
851010004089
IngredientAmount% DV
Calories72 Calorie(s)--
Total Carbohydrates10 Gram(s)3%
Sugar3 Gram(s)--
Total Fat0 Gram(s)--
Sodium20 mg1%
Potassium50 mg1%
Calcium0 NP2%
Chloride0 NP2%
Protein8 Gram(s)16%

Other ingredients: Water, Enzyme-hydrolyzed Collagen Protein, Maltodextrin, Dextrose, Beta-Alanine, Citrulline Malate, Citric Acid, Taurine, Potassium Chloride, Flavor, Calcium Chloride, Benzoate of Soda, Potassium Sorbate, Sodium Chloride, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No Caffeine

0g Fat Gluten free

Gluten & lactose free.

General Statements

Power - Speed - Endurance

Developed by Navy Seals

Rapid absorption at the cellular level

24 - 1.2 fl oz shots (36mL)

Typical hydrolyzed amino acids (g/100g protein) Alanine 11.3 Arginine 9.0 Aspartic Acid 6.7 Glutamic Acid 11.6 Glycine 27.2 Histidine 0.7 Hydroxylysine 0.8 Hydroxyproline 13.3 Isoleucine 1.5 Leucine 3.5 Lysine 4.4 Methionine 0.6 Phenylalanine 2.5 Proline 15.5 Serine 3.7 Threonine 3.4 Tyrosine 0.3 Valine 2.8

Rapidly adsorbed Protein near 100% at the cellular level

Enzyme-hydrolyzed Collagen Protein Lean muscle growth and recovery Joint health Fruit enzymes are used to break down the peptide bonds in the protein Since FrogFuel protein is broken up at the molecular level it is absorbed easily and immediately Simple & complex Carbohydrates Provides energy to fuel muscle contractions Prevents muscle tissue from being broken down to make glucose for energy Electrolytes Potassium, sodium, calcium, and chloride in proprietary ratios for maintaining proper fluid balance and muscle function Beta-Alanine Not found in proteins, helps prevent acid buildup in muscles Benefits include increased muscle mass, strength, and power output Increased endurance and helps delay onset of muscular fatigue Citrulline Malate A critical amino acid that assists in tissue health and repair Helps remove excess ammonia from the body, delaying fatigue and improving recovery Taurine When combined with our protein, taurine acts to quickly open the cells allowing the protein to enter and quickly rebuild muscle and improve recovery Reduces oxidative stress under extreme physical exertion where lactic acid builds up Helps regulate osmotic balance in muscle cells

Enzyme-hydrolyzed for rapid absorption FrogFuel is naturally hydrolyzed with a proteolytic (fruit) enzyme (not heat or acids) to a molecular level of 2000-5000 daltons. This means out protein is assimilated rapidly and almost instantly through the gut and into the blood stream. Even people with a compromised digestive tract easily assimilate FrogFuel. 100% protein digestibility <15 minutes FrogFuelActual @FrogFuelActual Instagram Facebook Linked In

Formula

8g Protein 10g Carbs

8g Protein 10 Carbs 1500Mg Beta-Alanine 21 Amino Acids 1500Mg Citrulline Malate

Protein - Carbohydrates - Electrolytes - Beta-Alanine - Citrulline Malate - Taurine

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: 15 min prior and every 45-90 minutes of performance.

Seals/Symbols

Made in Chile, USA

Brand IP Statement(s)

Science of FrogFuel Ultra

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Super Fuel Mixed Berry Flavored by Frog Fuel label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Super Fuel Mixed Berry Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Super Fuel Mixed Berry Flavored by Frog Fuel

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size36 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

3 Gram(s) per serving

Sodium

Interacts with
205 drugs
20 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
50 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Calcium

Interacts with
168 drugs
0 NP per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Chloride

0 NP per serving

Protein

8 Gram(s) per serving

Other (inactive) ingredients: Water, Enzyme-hydrolyzed Collagen Protein, Maltodextrin, Dextrose, Beta-Alanine, Citrulline Malate, Citric Acid, Taurine, Potassium Chloride, Flavor, Calcium Chloride, Benzoate of Soda, Potassium Sorbate, Sodium Chloride, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Super Fuel Mixed Berry Flavored by Frog Fuel Drug Interactions

Want to check YOUR meds against Ultra Super Fuel Mixed Berry Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
310Drugs
7 Major 301 Moderate 2 Minor

Ingredients driving the most interactions

Sodium 205
Calcium 168
Potassium 62

Individual Drug Interactions

The ingredients in Ultra Super Fuel Mixed Berry Flavored interact with 310 drugs. Click any drug to see the details.

3 of the 6 ingredients in Ultra Super Fuel Mixed Berry Flavored interact with drugs. Each result below shows which ingredient is responsible. Sodium Calcium Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Super Fuel Mixed Berry Flavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Super Fuel Mixed Berry Flavored, from the product label.

Frog Fuel

See all Frog Fuel products
Name
OP2 Labs
City
Ramona
State
CA
Phone Number
(888) 448-8468
Web Address
www.frogfuel.com
Pharmacist Counseling Corner

Ultra Super Fuel Mixed Berry Flavored by Frog Fuel: Common Questions

Does Ultra Super Fuel Mixed Berry Flavored by Frog Fuel interact with any medications?
Yes. Based on its ingredients, Ultra Super Fuel Mixed Berry Flavored has a known interaction with 310 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Super Fuel Mixed Berry Flavored contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have calcium in it?
Yes—calcium is one of the four active ingredients. It's also present in the calcium chloride listed in the inactive ingredients. If you take thyroid medication, HIV antivirals, or certain heart or blood pressure drugs, you'll need to check the timing carefully or talk to your pharmacist.
Can I take this while I'm pregnant or breastfeeding?
The data on this product's ingredients is mixed. Sodium is rated likely safe but possibly unsafe in pregnancy and lactation; potassium is likely safe; and calcium is likely safe but possibly unsafe. There isn't enough detail in the data we hold to give you a yes or no—talk with your doctor or pharmacist about what's right for you.
What's the sodium content used for in this product?
Sodium is an electrolyte that helps maintain fluid balance and nerve function. It's likely effective for cystic fibrosis and possibly effective for reducing kidney damage from amphotericin B, but normal dietary sodium is enough for healthy people—you don't need supplements unless your doctor says otherwise.
Will potassium in this product affect my blood pressure medication?
It depends on your specific medication. If you take an ACE inhibitor (like lisinopril), an ARB (like losartan), or a potassium-sparing diuretic, the potassium in this product can raise your blood potassium to dangerous levels. Check your exact medication with the tool on this page or call your pharmacist before starting.
Is this product safe if I have kidney disease?
That's a conversation for your doctor. Both potassium and sodium can be risky in kidney disease because your kidneys control how much of each you retain—too much can build up to unsafe levels. Don't start this without checking with your healthcare team first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Super Fuel Mixed Berry Flavored label
Go deeper

The Full Monographs Behind Ultra Super Fuel Mixed Berry Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Ultra Super Fuel Mixed Berry Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 112 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
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See these in context on the Sodium monograph →

Potassium 12 references
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Calcium 62 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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