Interactions on record — worth a quick check against your medications. Based on 4 of 10 ingredients. Check your meds →
Dietary supplement

XTEND Lemon Lime Sour Ingredients & Drug Interactions

by Scivation

XTEND Lemon Lime Sour label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking XTEND Lemon Lime Sour against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

XTEND Lemon Lime Sour is a dietary supplement by Scivation with 10 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 297 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against XTEND Lemon Lime Sour by Scivation

Ask about any prescription or over-the-counter medication and we check it for interactions with XTEND Lemon Lime Sour by Scivation — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of XTEND Lemon Lime Sour by Scivation

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

XTEND Lemon Lime Sour contains nine ingredients: L-glutamine, vitamin B6, sodium, potassium, L-leucine, L-isoleucine, L-valine, citrulline malate, and an electrolyte blend. The product has no inactive ingredients listed.

L-glutamine is an amino acid your body uses for gut health and immune function. L-leucine, L-isoleucine, and L-valine are branched-chain amino acids (BCAAs) that support muscle recovery after exercise.

Citrulline malate supports blood flow and endurance. Vitamin B6 helps your body use protein and make neurotransmitters.

Sodium and potassium are electrolytes that help with hydration, muscle function, and nerve signaling.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle building, fat loss, and recovery.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Critical illness (trauma), HIV/AIDS-related wasting, Malnutrition — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma), Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Burns, Muscular dystrophy.

The data we hold shows effectiveness ratings only for L-glutamine and sodium, not for the other active ingredients in this product. L-glutamine is rated effective for sickle cell disease and possibly effective for HIV/AIDS-related weight loss, postoperative recovery, and critical illness from trauma.

Sodium is rated likely effective for cystic fibrosis and possibly effective for amphotericin B kidney damage; evidence is insufficient to rate it for bipolar disorder or congestive heart failure. We have no effectiveness data on file for L-leucine, L-isoleucine, L-valine, or citrulline malate.

The evidence, ingredient by ingredient Glutamine Vitamin B6 Sodium Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is rated likely safe in pregnancy and lactation. Vitamin B6 safety data during pregnancy and breastfeeding isn't on file.

Sodium is rated likely safe in pregnancy but possibly unsafe in lactation. Potassium is rated likely safe in both pregnancy and lactation.

L-glutamine is generally well tolerated but can cause belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, and gastrointestinal pain—especially at high doses (10–30 grams daily). Vitamin B6 is well tolerated at doses under 100 mg daily but can cause nerve damage (sensory neuropathy) at very high doses or over long periods.

Sodium is well tolerated in moderate amounts but too much is linked to high blood pressure, kidney disease, and heart strain. Potassium is generally well tolerated from food but can cause dangerously high potassium levels that affect your heart rhythm if you take supplements, especially if you have kidney disease.

Side effects, ingredient by ingredient Glutamine Vitamin B6 Sodium Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Potassium, Glutamine, Vitamin B6, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; lithium; Parkinson's medications.
  • For scale: 297 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take XTEND, check with your pharmacist if you're on anticonvulsant medications (seizure drugs), antihypertensive drugs (blood pressure medications), amiodarone (heart rhythm medication), phenobarbital or phenytoin (seizure drugs), potassium-sparing diuretics, ACE inhibitors, ARBs, corticosteroids, lithium, or levodopa. These are the medication types with documented interactions—the most serious being the potential to reduce how well seizure and blood pressure medications work, or to cause dangerously high potassium or sodium levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may work well for muscle recovery and hydration in healthy people without blood pressure, heart, kidney, or seizure conditions. If you take any antihypertensive, seizure, heart rhythm, or potassium-affecting medications—or if you have kidney disease—talk with your pharmacist before starting.

The same goes if you take lithium. Check your exact medications with the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about XTEND Lemon Lime Sour, straight from the product label.

Brand Scivation
Net contents 420 g
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 13369
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for XTEND Lemon Lime Sour by Scivation, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12.8 Gram(s)
Maximum serving Sizes:
12.8 Gram(s)
Servings per container
30
IngredientAmount% DV
Calories0 {Calories}--
Total Carbohydrates0 g--
L-Glutamine2500 mg--
Sugar0 g--
Calories from Fat0 {Calories}--
Total Fat0 g--
Vitamin B61 mg11%
Sodium230 mg10%
Potassium170 mg5%
Cholesterol0 mg--
L-Leucine3500 mg--
L-Isoleucine1750 mg--
L-Valine1750 mg--
Citrulline Malate1000 mg--
ELECTROLYTE BLEND1120 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

AVAILABLE IN 30-SERVING BOTTLE (420 G) 90-SERVING (1260 G), SINGLE SERVING STICK PACKS, and 30-CT STICK PACK VARIETY BOX

BUILD MUSCLE - BURN FAT - RECOVER FATSER

- 3500 mg L-Leucine For Muscle Protein Synthesis - 7000 mg BCAAs

XTEND INTRA-WORKOUT CATALYST Build Muscle - Burn Fat - Aid Recovery

XTEND was recently reformulated to dramatically improve taste and ingredient solubility. XTEND is easily mixed with a spoon and provides added functionality for workouts or events under the most grueling of conditions. XTEND is available in six mouth-watering, refreshing fruit flavors to make every workout your most intense.

INTRA-WORKOUT FORMULA

XTEND is scientifically formulated to maximize training intensity and promote optimal muscle protein synthesis and recovery while you train. Proven effective in two university studies, XTEND is formulated with a precise PentActive blend of active ingredients, synergistically involved in key cellular processes to optimize muscle performance and response: • 7000 mg of BCAAs in a research-proven ratio

Formula

• 3500 mg of Leucine • 2500 mg of Glutamine • 1000 mg of Citrulline Malate • 1171 mg of Electrolytes • 640 mcg of Vitamin B6

- Over 4600 mg of L-Glutamine, Citrulline Malate & Electrolytes

Formulation

ZERO Sugar or Carbs

• And, zero Carbohydrates or Sugar

FDA Statement of Identity

DIETARY SUPPLEMENT

Brand IP Statement(s)

The new Scivation XTEND(TM) is the most advanced SUGAR FREE and CARBOHYDRATE FREE Intra-Workout Catalyst in the world!

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, mix one serving (one level scoop) of Scivation XTEND(TM) per 10 fluid ounces of water. Shake well and consume during exercise on training days or throughout the day on non-training days.

Precautions

Warnings: Keep out of reach of children.

Always consult a physician prior to using any dietary supplements.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

XTEND Lemon Lime Sour by Scivation label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

XTEND Lemon Lime Sour label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in XTEND Lemon Lime Sour by Scivation

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size12.8 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
2500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Sugar

0 g per serving

Vitamin B6

Interacts with
210 drugs
1 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Sodium

Interacts with
205 drugs
230 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
170 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

L-Leucine

3500 mg per serving

L-Isoleucine

1750 mg per serving

L-Valine

1750 mg per serving

Citrulline Malate

1000 mg per serving

ELECTROLYTE BLEND

1120 mg per serving Form: Potassium Chloride, Sodium Chloride, Trisodium Citrate Dihydrate
Interaction report

XTEND Lemon Lime Sour by Scivation Drug Interactions

Want to check YOUR meds against XTEND Lemon Lime Sour?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
297Drugs
292 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210
Sodium 205
Potassium 62
L-Glutamine 50

Individual Drug Interactions

The ingredients in XTEND Lemon Lime Sour interact with 297 drugs. Click any drug to see the details.

4 of the 10 ingredients in XTEND Lemon Lime Sour interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Sodium Potassium L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in XTEND Lemon Lime Sour with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for XTEND Lemon Lime Sour, from the product label.

Scivation

See all Scivation products
Name
Scivation
Pharmacist Counseling Corner

XTEND Lemon Lime Sour by Scivation: Common Questions

Does XTEND Lemon Lime Sour by Scivation interact with any medications?
Yes. Based on its ingredients, XTEND Lemon Lime Sour has a known interaction with 297 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
XTEND Lemon Lime Sour contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-glutamine safe during pregnancy or while breastfeeding?
L-glutamine is rated likely safe in pregnancy and lactation according to the data we hold. Vitamin B6 safety data during pregnancy and breastfeeding isn't on file, so talk with your doctor or pharmacist. Sodium is likely safe in pregnancy but possibly unsafe while breastfeeding, and potassium is likely safe in both. Since this product contains multiple ingredients, discuss it with your clinician before use during pregnancy or nursing.
Can this powder cause stomach upset?
Yes. L-glutamine, especially in higher amounts, can cause belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, and abdominal pain. Potassium can cause similar digestive side effects. Vitamin B6 at standard doses can cause abdominal pain, nausea, and vomiting. Most people tolerate it well, but if you have a sensitive stomach, start with a smaller dose.
What is L-glutamine for?
L-glutamine is an amino acid your body uses for gut health, immune function, and muscle support. The data shows it's effective for sickle cell disease and possibly effective for recovery after surgery, trauma, and HIV/AIDS-related weight loss.
What do the branched-chain amino acids (BCAAs) do?
L-leucine, L-isoleucine, and L-valine are BCAAs that help support muscle recovery and protein use during and after exercise. We don't have effectiveness ratings on file for these three ingredients, so their benefits in this product aren't rated in our data.
Is this safe if I have kidney disease?
No—talk with your doctor first. L-glutamine should only be used under medical supervision if you have kidney or liver disease. Potassium supplements can be dangerous for people with kidney disease because your kidneys may not clear excess potassium safely, leading to dangerously high levels. Your doctor needs to assess whether this product is right for you.
What's the sodium and potassium content?
The product facts don't specify the exact amounts of sodium and potassium in each serving, only that they're present. If you need to know the exact dose—especially if you're on blood pressure medications, heart drugs, or have kidney disease—check the product label or contact the manufacturer.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

XTEND Lemon Lime Sour label
Go deeper

The Full Monographs Behind XTEND Lemon Lime Sour’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

XTEND Lemon Lime Sour's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 93 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
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Sodium 38 references
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See these in context on the Sodium monograph →

Potassium 12 references
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  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
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See these in context on the Potassium monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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