Yohimbine+ Rauwolscine Ingredients & Drug Interactions
by ALLMAX
What is this page for?
First and foremost: checking Yohimbine+ Rauwolscine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Yohimbine+ Rauwolscine is a dietary supplement by ALLMAX with 2 active ingredients. Its ingredients are commonly taken for erectile dysfunction, low sex drive, sexual performance.Based on those ingredients, 1,294 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Yohimbine Hydrochloride, Rauwolscine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Yohimbine+ Rauwolscine by ALLMAX
Ask about any prescription or over-the-counter medication and we check it for interactions with Yohimbine+ Rauwolscine by ALLMAX — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Yohimbine+ Rauwolscine by ALLMAX
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Yohimbine+ Rauwolscine is a 2-ingredient formula. The active ingredients are yohimbine hydrochloride and rauwolscine — both are alkaloids structurally related to each other.
The product also contains inactive ingredients: bovine gelatin (capsule material), magnesium stearate (a lubricant), and rice flour (a filler).
Does it work?
Not established
The evidence we hold is insufficient to rate rauwolscine for athletic performance, weight loss, or sexual arousal. The data doesn't establish that it works for these uses.
If you're considering this product for any of those purposes, talk with your pharmacist about what the current research actually supports.
How safe is it?
Well-documented data
Rauwolscine is a potent stimulant with limited human safety data and can affect heart rate and blood pressure — use with caution. Although no adverse effects have been reported in oral use so far, a thorough safety evaluation hasn't been done.
Because rauwolscine is structurally related to yohimbine, it might theoretically cause similar effects — including anxiety, tremors, dizziness, headache, flushing, seizures, loss of consciousness, and paralysis, though these are rare. There isn't enough safety data to know whether rauwolscine is safe during pregnancy or breastfeeding.
The facts advise against use in both cases. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning pregnancy, or breastfeeding.
Meds to double-check
Major interaction found
Before taking this product, check with your pharmacist if you take seizure threshold lowering drugs, medications metabolized by the liver enzyme CYP2D6 (many antidepressants and heart drugs), blood thinners or antiplatelet drugs, calcium channel blockers, stimulant medications, or clonidine — all have Moderate-severity theoretical interactions with rauwolscine.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
Rauwolscine is a potent stimulant with limited human safety data and multiple theoretical drug interactions — particularly with seizure medications, liver-metabolized drugs, blood thinners, heart medications, and other stimulants. If you take any prescription medications, check them against the interaction tool before starting.
Pregnancy and breastfeeding are contraindicated. A conversation with your pharmacist about your specific health and medications is a good first step.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Yohimbine+ Rauwolscine, straight from the product label.
| Brand | ALLMAX |
|---|---|
| Barcode (UPC) | 665553223537 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2023 |
| DSLD ID | 296149 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Yohimbine+ Rauwolscine by ALLMAX, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Yohimbine Hydrochloride | 3 mg | -- |
| Rauwolscine | 0.5 mg | -- |
Other ingredients: Bovine Gelatin, Magnesium Stearate, Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Professional grade supplements
Suggested/Recommended/Usage/Directions
Directions: Take 1 capsule daily just prior to exercise. Do not exceed 2 capsules daily.
Formula
Allmax Yohimbine + Rauwolscine (Alpha-Yohimbine) are the pure synthetic versions of Pausinystalia Yohimbine and Rauwolfia serpentina; thousands of times more powerful than the original herbal extracts from which they were isolated.
Formulation
Most frequently used for rapid fat loss due to its targeted ability to act on store fat, Yohimbine + Rauwolscine limits fat storage and boosts lipolysis; the release of fatty acids within stored fat. Yohimbine has an extremely high affinity for the Alpha 2-adrenoreceptor (Alpha 2-AR). These receptors (primarily in fat cells) control the rate of release of stored fat. As antagonists, Yohimbine & Rauwolscine lock on to Alpha 2 fat cell receptors. Fat storage is deactivated and rapid release of stored fat in initiated. Rauwolscine (or Alpha-Yohimbine), is an extremely rare variation of Yohimbine with a longer half-life and a more powerful Alpha 2-AR affinity. This means you need less of it to create a greater effect; it lasts longer and is the perfect complement to Yohimbine. Yohimbine + Rauwolscine is one of the most effective and efficient fat loss aids. Widely praised for its unique MOA (mechanism of action), Yohimbine + Rauwolscine is radically different than caffeine.
While caffeine is one of the best fat loss analogs out there, those who are looking to "cycle off" caffeine can use Yohimbine + Rauwolscine to affect fat loss in a completely different way.
Product of USA
Supports fat-burning Suppresses appetite
Seals/Symbols
cGMP Registered Facility
Quality Guarantee Purity & Potency Tested
Brand IP Statement(s)
Copyright 2021 Allmax Nutrition Inc. All rights reserved. Trademarks are property of their respective owners.
ALLMAX ESSENTIALS Science Innovation Quality Results
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Precautions
Warnings: Do not use if pregnant or nursing. Consult a medical doctor before use if you have been treated for, or diagnose with or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. Consult your healthcare professional before use if you are taking antidepressants, MAO inhibitors or any other prescription drug.
Discontinue use and consult a medical doctor if you experience unusual symptoms. Discontinue use two weeks prior to surgery. Consult a medical doctor before use if you have been treated for, or diagnose with or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. Do not use this product if you are at risk or are being treated for high blood pressure, heart, kidney, thyroid or psychiatric disease, anxiety, depression, seizure disorder or stroke. Discontinue use and consult your healthcare professional if dizziness, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Improper use of this product will not improve results, is not advised and may cause adverse reactions listed in the warning. Consult a medical doctor before starting any diet or exercise. Do not use if inner seal is broken.
Keep out of reach of children.
California Warning: Lead is known to the State of California to cause birth defects or reproductive harm. Consuming this product can expose you to more than 0.0000005 g of lead. For more information go to www.P65Warnings.ca.gov. Prop 65
Allergen Warning: Produced in a facility that also handles milk, soy, wheat, egg, peanut, tree nuts, fish, crustacean and shellfish products.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Yohimbine+ Rauwolscine by ALLMAX label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Yohimbine+ Rauwolscine by ALLMAX
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Yohimbine Hydrochloride
Interacts with1,125 drugs
Yohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription...
Yohimbine Hydrochloride monograph & interactionsRauwolscine
Interacts with677 drugs
Rauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout supplements....
Rauwolscine monograph & interactionsOther (inactive) ingredients: Bovine Gelatin, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.
Yohimbine+ Rauwolscine by ALLMAX Drug Interactions
HelloPharmacist Interaction Report
Yohimbine+ Rauwolscine by ALLMAX contains rauwolscine, which has documented theoretical interactions with several medication types.
The most serious concern is with seizure threshold lowering drugs (Moderate severity) — rauwolscine may increase the risk of seizures. Animal research showed that rauwolscine lowered the seizure threshold in lab models.
Read the full breakdown — every affected drug type, severity by severity
Rauwolscine also interacts with drugs metabolized by the liver enzyme CYP2D6, including many antidepressants and heart medications (Moderate severity) — it may raise their blood levels and effects. It has theoretical antiplatelet effects (Moderate severity), so combining it with blood thinners or antiplatelet drugs like aspirin could increase bleeding risk.
Calcium channel blockers used for high blood pressure or heart conditions (Moderate severity) may have added effects on blood vessel dilation. Stimulant drugs — whether prescription ADHD medications or others (Moderate severity) — could have additive stimulant effects.
Clonidine (Catapres), used for high blood pressure or ADHD, may be less effective (Moderate severity).
We could not check yohimbine hydrochloride for interactions — no data is on file for it.
Altogether, these interactions span 676 individual medications. Use the medication checker on this page to look up your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Yohimbine+ Rauwolscine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Yohimbine+ Rauwolscine interact with 1,294 drugs. Click any drug to see the details.
2 of the 2 ingredients in Yohimbine+ Rauwolscine interact with drugs. Each result below shows which ingredient is responsible. Yohimbine Hydrochloride Rauwolscine
AmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideStimulant Drugs, Monoamine Oxidase Inhibitors (maois) +1 Major
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbine Hydrochloride + Amphetamine interactionRauwolscineSeizure Threshold Lowering Drugs, Stimulant Drugs +1 Moderate
Interaction Summary
Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full Rauwolscine + Amphetamine interactionIsocarboxazidMarplan
How Isocarboxazid interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbine Hydrochloride + Isocarboxazid interactionMoclobemideManerix, Moclobemide
How Moclobemide interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 2d6 (cyp2d6) Inhibitors, Monoamine Oxidase Inhibitors (maois) Major
Interaction Summary
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
Read the full Yohimbine Hydrochloride + Moclobemide interactionOzanimod HydrochlorideZeposia
How Ozanimod Hydrochloride interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbine Hydrochloride + Ozanimod Hydrochloride interactionPhenelzine SulfateNardil
How Phenelzine Sulfate interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbine Hydrochloride + Phenelzine Sulfate interactionRasagilineAzilect
How Rasagiline interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 1a2 (cyp1a2) Substrates, Monoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbine Hydrochloride + Rasagiline interactionSafinamide MesylateXadago
How Safinamide Mesylate interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbine Hydrochloride + Safinamide Mesylate interactionSelegilineCarbex, Eldepryl, Emsam, Zelapar
How Selegiline interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbine Hydrochloride + Selegiline interactionTranylcypromineParnate
How Tranylcypromine interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Concomitant use of MAOIs with yohimbe can result in additive effects.
Read the full Yohimbine Hydrochloride + Tranylcypromine interactionAbametapirXeglyze
How Abametapir interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 3a4 (cyp3a4) Inhibitors Moderate
Interaction Summary
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
Read the full Yohimbine Hydrochloride + Abametapir interactionAbciximabReoPro
How Abciximab interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
RauwolscineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rauwolscine may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rauwolscine + Abciximab interactionYohimbine HydrochlorideAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Read the full Yohimbine Hydrochloride + Abciximab interactionAbiraterone
How Abiraterone interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbine Hydrochloride + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbine Hydrochloride + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
RauwolscineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rauwolscine may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rauwolscine + Abrocitinib interactionYohimbine HydrochlorideAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Read the full Yohimbine Hydrochloride + Abrocitinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochlorideAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Read the full Yohimbine Hydrochloride + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
RauwolscineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rauwolscine may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rauwolscine + Acenocoumarol interactionYohimbine HydrochlorideAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Read the full Yohimbine Hydrochloride + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Yohimbine+ Rauwolscine — through 1 ingredient. Tap an ingredient for the detail:
Yohimbine HydrochloridePhenothiazines Moderate
Interaction Summary
Theoretically, using yohimbine with phenothiazines might have additive effects.
Read the full Yohimbine Hydrochloride + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
RauwolscineAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rauwolscine may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rauwolscine + Acetaminophen, Aspirin interactionYohimbine HydrochlorideCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Read the full Yohimbine Hydrochloride + Acetaminophen, Aspirin, Caffeine interactionRauwolscineStimulant Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.
Read the full Rauwolscine + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideStimulant Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbine Hydrochloride + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionRauwolscineSeizure Threshold Lowering Drugs, Stimulant Drugs Moderate
Interaction Summary
Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full Rauwolscine + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Butalbital, Caffeine interactionRauwolscineStimulant Drugs Moderate
Interaction Summary
Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.
Read the full Rauwolscine + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
RauwolscineStimulant Drugs, Seizure Threshold Lowering Drugs +1 Moderate
Interaction Summary
Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.
Read the full Rauwolscine + Acetaminophen, Butalbital, Caffeine, Codeine interactionYohimbine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
RauwolscineCytochrome P450 2d6 (cyp2d6) Substrates, Seizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, rauwolscine might increase levels of drugs metabolized by CYP2D6.
Read the full Rauwolscine + Acetaminophen, Butalbital, Codeine interactionYohimbine HydrochlorideCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Butalbital, Codeine Phosphate interactionRauwolscineCytochrome P450 2d6 (cyp2d6) Substrates, Seizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, rauwolscine might increase levels of drugs metabolized by CYP2D6.
Read the full Rauwolscine + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
RauwolscineSeizure Threshold Lowering Drugs, Stimulant Drugs +1 Moderate
Interaction Summary
Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full Rauwolscine + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionYohimbine HydrochlorideCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Inhibitors +3 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideStimulant Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbine Hydrochloride + Acetaminophen, Caffeine, Codeine interactionRauwolscineSeizure Threshold Lowering Drugs, Stimulant Drugs +1 Moderate
Interaction Summary
Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full Rauwolscine + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Caffeine, Codeine, Salicylamide interactionRauwolscineSeizure Threshold Lowering Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
Read the full Rauwolscine + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
RauwolscineStimulant Drugs, Seizure Threshold Lowering Drugs +1 Moderate
Interaction Summary
Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.
Read the full Rauwolscine + Acetaminophen, Caffeine, Dihydrocodeine interactionYohimbine HydrochlorideStimulant Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Read the full Yohimbine Hydrochloride + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 1a2 (cyp1a2) Substrates, Stimulant Drugs +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Caffeine, Isometheptene interactionRauwolscineStimulant Drugs Moderate
Interaction Summary
Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.
Read the full Rauwolscine + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Yohimbine+ Rauwolscine — through 2 ingredients. Tap an ingredient for the detail:
Yohimbine HydrochlorideCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Yohimbine Hydrochloride + Acetaminophen, Caffeine, Pyrilamine interactionRauwolscineStimulant Drugs Moderate
Interaction Summary
Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.
Read the full Rauwolscine + Acetaminophen, Caffeine, Pyrilamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Yohimbine+ Rauwolscine with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Yohimbine Hydrochloride
Monoamine Oxidase Inhibitors (Maois)
Concomitant use of MAOIs with yohimbe can result in additive effects.
Yohimbine, a constituent of yohimbe, has MAO inhibitory effects. At high doses, yohimbine is a non-selective inhibitor of MAO.
Antihypertensive Drugs
Theoretically, yohimbe might reduce the effects of antihypertensive drugs.
Yohimbine, a constituent of yohimbe, is an alpha-2 adrenoceptor antagonist and has been reported to increase blood pressure in clinical research. Theoretically, concomitant use of yohimbe and antihypertensive drugs can interfere with blood pressure control.
Clonidine (Catapres)
Theoretically, yohimbe might precipitate clonidine withdrawal.
Chronic clonidine use can downregulate alpha-2 adrenoreceptors. Animal research and one human case report suggest that concomitant administration of yohimbine, an alpha-2 adrenoceptor antagonist, may precipitate clonidine withdrawal and lead to sympathomimetic toxicity, including hypertensive crisis.
Cytochrome P450 2D6 (Cyp2D6) Inhibitors
CYP2D6 inhibitors may increase the levels and adverse effects of yohimbine, a constituent of yohimbe.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP2D6 isoenzymes. Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine and reduces the clearance of yohimbine compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers..
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.
In vitro research suggests that yohimbine, a constituent of yohimbe bark, inhibits CYP2D6 enzyme activity.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of yohimbine, a constituent of yohimbe bark.
In vitro and clinical research shows that the yohimbe bark constituent, yohimbine, is metabolized by CYP3A4 enzymes. Theoretically, drugs that inhibit CYP3A4 might increase the levels and adverse effects of yohimbine.
Paroxetine (Paxil)
Paroxetine decreases the clearance of yohimbine and may increase its effects.
Paroxetine, a cytochrome P450 (CYP) 2D6 inhibitor, increases the maximum serum concentration of yohimbine by about 350% and reduces the clearance of yohimbine by about 80% compared to yohimbine alone in patients who are extensive CYP2D6 metabolizers. No significant changes in pharmacokinetic parameters of yohimbine were observed with coadministration of paroxetine in patients who are poor CYP2D6 metabolizers.
Phenothiazines
Theoretically, using yohimbine with phenothiazines might have additive effects.
Yohimbine, a constituent of yohimbe, has alpha-2 adrenergic antagonist effects. Theoretically, combining it with phenothiazines can cause additive alpha-2 adrenergic antagonism.
Stimulant Drugs
Theoretically, taking yohimbe with stimulant drugs can have additive effects.
Yohimbine, a constituent of yohimbe, has sympathomimetic effects and increases blood pressure in a dose-dependent manner. Theoretically, taking yohimbe with stimulant drugs can have additive stimulant and hypertensive effects.
Tricyclic Antidepressants (Tcas)
Theoretically, taking yohimbe with TCAs can increase adverse effects.
A small clinical study in patients taking TCAs for at least 4 weeks shows that receiving doses of intravenous yohimbine 2.5-20 mg daily for up to 7 days precipitates severe anxiety, agitation, and tremor. The effects of yohimbe bark itself are unclear; oral yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Anticoagulant/Antiplatelet Drugs
Theoretically, combining yohimbe bark with antiplatelet or anticoagulant drugs might have additive effects; however, this has not been reported in clinical research.
Research in healthy adults shows that taking yohimbine, a constituent of yohimbe bark, in doses of 8 mg or more, seems to inhibit platelet aggregation in vitro by binding to the alpha-2 adrenoceptor. The effects of yohimbe bark itself are unclear; yohimbe bark contains 0.6% to 1.38% yohimbine, but it is unclear how much is absorbed.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that yohimbe extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, yohimbe might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that yohimbe extract induces CYP3A4 enzymes.
Rauwolscine
Anticoagulant/Antiplatelet Drugs
Theoretically, rauwolscine may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits platelet aggregation.
Calcium Channel Blockers
Theoretically, rauwolscine may have additive coronary vasodilatory effects if used with calcium channel blockers.
In vitro, rauwolscine inhibits calcium influx in aortic smooth muscle cells.
Clonidine (Catapres)
Theoretically, rauwolscine may inhibit the effects of clonidine.
In animal research, rauwolscine antagonized the effects of clonidine.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, rauwolscine might increase levels of drugs metabolized by CYP2D6.
Rauwolscine is structurally related to yohimbine. In vitro research shows that yohimbine inhibits CYP2D6 enzyme activity.
Seizure Threshold Lowering Drugs
Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.
In animal research, intraperitoneal rauwolscine lowered the seizure threshold level of the drug metrazol.
Stimulant Drugs
Theoretically, taking rauwolscine with stimulant drugs might increase the risk of adverse stimulant effects.
Rauwolscine has demonstrated stimulant effects in animal research.
Brand information
Manufacturer and brand details for Yohimbine+ Rauwolscine, from the product label.
ALLMAX
- Name
- HBS INTERNATIONAL CORP.
- Street Address
- 711 S. Carson St., Suite 4
- City
- Carson City
- State
- NV
- Web Address
- www.ALLMAXNUTRITION.com
Yohimbine+ Rauwolscine by ALLMAX: Common Questions
Does Yohimbine+ Rauwolscine by ALLMAX interact with any medications?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Yohimbine+ Rauwolscine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Yohimbine+ Rauwolscine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Yohimbe
Interacts with 1,125 drugsYohimbe is a West African tree bark that contains yohimbine, a compound mainly promoted for erectile dysfunction and as an aphrodisiac. A prescription form of yohimbine has some evidence for...
Read the full Yohimbe monograph → Herb & supplement monographRauwolscine
Interacts with 677 drugsRauwolscine (alpha-yohimbine) is a stimulant alkaloid closely related to yohimbine that is marketed mainly in fat-burning and pre-workout supplements. Human evidence for its benefits is very...
Read the full Rauwolscine monograph →Sources & How We Checked
Yohimbine+ Rauwolscine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 94 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Yohimbe 66 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
- Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
- Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
- Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
- Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
- Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
- VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
- Abebe, W. An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations. J Dent.Hyg. 2003;77(1):37-46.
- Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
- Cameron, O. G., Zubieta, J. K., Grunhaus, L., and Minoshima, S. Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans. Psychosom.Med 2000;62(4):549-559. PubMed
- Bowes, M. P., Peters, R. H., Kernan, W. J., Jr., and Hopper, D. L. Effects of yohimbine and idazoxan on motor behaviors in male rats. Pharmacol.Biochem.Behav. 1992;41(4):707-713.
- Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed
- Bagheri, H., Bompart, G., Girolami, J. P., Montastruc, J. L., and Montastruc, P. Is yohimbine-induced increase in salivary secretion a kinin-dependent mechanism? Fundam.Clin Pharmacol 1992;6(1):17-20. PubMed
- Swann, A. C., Birnbaum, D., Jagar, A. A., Dougherty, D. M., and Moeller, F. G. Acute yohimbine increases laboratory-measured impulsivity in normal subjects. Biol.Psychiatry 5-15-2005;57(10):1209-1211. PubMed
- Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
- Murburg, M. M., Villacres, E. C., Ko, G. N., and Veith, R. C. Effects of yohimbine on human sympathetic nervous system function. J Clin Endocrinol.Metab 1991;73(4):861-865. PubMed
- Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
- Bloomer, R. J., Canale, R. E., Blankenship, M. M., Hammond, K. G., Fisher-Wellman, K. H., and Schilling, B. K. Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized,
- Myers, A. and Barrueto, F., Jr. Refractory priapism associated with ingestion of yohimbe extract. J Med Toxicol. 2009;5(4):223-225.
- Berlin, I., Crespo-Laumonnier, B., Cournot, A., Landault, C., Aubin, F., Legrand, J. C., and Puech, A. J. The alpha 2-adrenergic receptor antagonist yohimbine inhibits epinephrine-induced platelet aggregation in healthy subjects. Clin Pharmacol.Ther. 199
- Swann, A. C. Mechanisms of impulsivity in bipolar disorder and related illness. Epidemiol.Psichiatr.Soc. 2010;19(2):120-130.
- Shibao, C., Okamoto, L. E., Gamboa, A., Yu, C., Diedrich, A., Raj, S. R., Robertson, D., and Biaggioni, I. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension 2010;56(5) PubMed
- Soeter, M. and Kindt, M. Stimulation of the noradrenergic system during memory formation impairs extinction learning but not the disruption of reconsolidation. Neuropsychopharmacology 2012;37(5):1204-1215. PubMed
- Cimolai, N. and Cimolai, T. Yohimbine use for physical enhancement and its potential toxicity. J Diet.Suppl 2011;8(4):346-354. PubMed
- Bagheri, H., Berlan, M., Montastruc, J. L., and Montastruc, P. Yohimbine and lacrimal secretion. Br J Clin Pharmacol. 1990;30(1):151-152.
- Landis, E. and Shore, E. Yohimbine-induced bronchospasm. Chest 1989;96(6):1424. PubMed
- Susset, J. G., Tessier, C. D., Wincze, J., Bansal, S., Malhotra, C., and Schwacha, M. G. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol. 1989;141(6):1360-1363. PubMed
- Chatelut, E., Rispail, Y., Berlan, M., and Montastruc, J. L. Yohimbine increases human salivary secretion. Br.J Clin Pharmacol. 1989;28(3):366-368. PubMed
- Montastruc, P., Berlan, M., and Montastruc, J. L. Effects of yohimbine on submaxillary salivation in dogs. Br J Pharmacol 1989;98(1):101-104. PubMed
- Charney, D. S., Price, L. H., and Heninger, G. R. Desipramine-yohimbine combination treatment of refractory depression. Implications for the beta-adrenergic receptor hypothesis of antidepressant action. Arch.Gen.Psychiatry 1986;43(12):1155-1161. PubMed
- Braddock, L., Cowen, P. J., Elliott, J. M., Fraser, S., and Stump, K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol.Med 1986;16(4):765-773. PubMed
- Bolme, P., Corrodi, H., Fuxe, K., Hokfelt, T., Lidbrink, P., and Goldstein, M. Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine. Eur J Pharm PubMed
- Charney, D. S., Heninger, G. R., and Sternberg, D. E. Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of oral yohimbine. Life Sci 6-7-1982;30(23):2033-2041.
- Boon, N. A., Elliott, J. M., Grahame-Smith, D. G., John-Green, T., and Stump, K. A comparison of alpha 2-adrenoreceptor binding characteristics of intact human platelets identified by [3H]-yohimbine and [3H]- dihydroergocryptine. J Auton.Pharmacol 1983;3
- Andrejak, M., Ward, M., and Schmitt, H. Cardiovascular effects of yohimbine in anaesthetized dogs. Eur.J Pharmacol 10-28-1983;94(3-4):219-228. PubMed
- Brodde, O. E., Anlauf, M., Arroyo, J., Wagner, R., Weber, F., and Buck, K. D. Hypersensitivity of adrenergic receptors and blood-pressure response to oral yohimbine in orthostatic hypotension. N.Engl.J Med 4-28-1983;308(17):1033-1034. PubMed
- Charney, D. S., Heninger, G. R., and Redmond, D. E., Jr. Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. Life Sci. 7-4-1983;33(1):19-29. PubMed
- Knoll, L. D., Benson, R. C., Jr., Bilhartz, D. L., Minich, P. J., and Furlow, W. L. A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence. J Urol. 1996;155(1):144-146. DOI
- Betz, J. M., White, K. D., and der Marderosian, A. H. Gas chromatographic determination of yohimbine in commercial yohimbe products. J AOAC Int 1995;78(5):1189-1194. DOI
- Bagheri, H., Chale, J. J., Guyen, L. N., Tran, M. A., Berlan, M., and Montastruc, J. L. Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha 2-adrenoceptor antagonist. Fundam.Clin Pharmacol 1995;9(3):248-254.
- Kennedy, S. H., Gnam, W., Ralevski, E., and Brown, G. M. Melatonin responses to clonidine and yohimbine challenges. J Psychiatry Neurosci. 1995;20(4):297-304.
- Musso, N. R., Vergassola, C., Pende, A., and Lotti, G. Yohimbine effects on blood pressure and plasma catecholamines in human hypertension. Am J Hypertens. 1995;8(6):565-571. PubMed
- Morgan, C. A., III, Southwick, S. M., Grillon, C., Davis, M., Krystal, J. H., and Charney, D. S. Yohimbine-facilitated acoustic startle reflex in humans. Psychopharmacology (Berl) 1993;110(3):342-346. PubMed
- Adler, L. E., Hoffer, L., Nagamoto, H. T., Waldo, M. C., Kisley, M. A., and Giffith, J. M. Yohimbine impairs P50 auditory sensory gating in normal subjects. Neuropsychopharmacology 1994;10(4):249-257. PubMed
- Biaggioni, I., Robertson, R. M., and Robertson, D. Manipulation of norepinephrine metabolism with yohimbine in the treatment of autonomic failure. J Clin Pharmacol. 1994;34(5):418-423. PubMed
- Kenney, W. L., Zappe, D. H., Tankersley, C. G., and Derr, J. A. Effect of systemic yohimbine on the control of skin blood flow during local heating and dynamic exercise. Am J Physiol 1994;266(2 Pt 2):H371-H376. PubMed
- Friesen, K., Palatnick, W., and Tenenbein, M. Benign course after massive ingestion of yohimbine. J Emerg.Med 1993;11(3):287-288. PubMed
- Bierer, L. M., Aisen, P. S., Davidson, M., Ryan, T. M., Stern, R. G., Schmeidler, J., and Davis, K. L. A pilot study of oral physostigmine plus yohimbine in patients with Alzheimer disease. Alzheimer Dis.Assoc.Disord. 1993;7(2):98-104. PubMed
- Mann, K., Klingler, T., Noe, S., Roschke, J., Muller, S., and Benkert, O. Effects of yohimbine on sexual experiences and nocturnal penile tumescence and rigidity in erectile dysfunction. Arch.Sex Behav. 1996;25(1):1-16. PubMed
- Rowland, D. L., Kallan, K., and Slob, A. K. Yohimbine, erectile capacity, and sexual response in men. Arch Sex Behav 1997;26(1):49-62.
- Bremner, J. D., Innis, R. B., Ng, C. K., Staib, L. H., Salomon, R. M., Bronen, R. A., Duncan, J., Southwick, S. M., Krystal, J. H., Rich, D., Zubal, G., Dey, H., Soufer, R., and Charney, D. S. Positron emission tomography measurement of cerebral metaboli
- Riley AJ, Goodman R, Kellett JM, and et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual Marital Ther 1989;4(1):17-26. DOI
- Cohen PA, Wang YH, Maller G, DeSouza R, Khan IA. Pharmaceutical quantities of yohimbine found in dietary supplements in the USA. Drug Test Anal. 2015 Sep 22. PubMed
- Ruck B, Shih RD, Marcus SM. Hypertensive crisis from herbal treatment of impotence. Am J Emerg Med. 1999;17:317-318. PubMed
- Wylie KR. Yohimbine and sinusitis. Br J Psychiatry. 1996;169(3):384-5. PubMed
- Le Corre P, Parmer RJ, Kailasam MT, et al. Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism. Clin Pharmacol Ther. 2004;76(2):139-53.
- Mueller-Schoell A, Michelet R, Weinelt F, Kloft C, Mikus G. CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications. Arch Toxicol. 2021. PubMed
- Bharucha AE, Skaar T, Andrews CN, et al Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil. 2008;20(8):891-9. PubMed
- Schmauss M, Laakmann G, Dieterle D. Effects of alpha 2-receptor blockade in addition to tricyclic antidepressants in therapy-resistant depression. J Clin Psychopharmacol. 1988;8(2):108-11.
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Hodapp B, Haggerty A, Feldman R, Timpe J. Intracranial hemorrhage after a single dose of Yohimbine in a chronic user of clonidine. Am J Emerg Med 2022;62:145. PubMed
- Vay M, Meyer MJ, Blank A, et al. Oral yohimbine as a new probe drug to predict CYP2D6 activity: results of a fixed-sequence phase I trial. Clin Pharmacokinet. 2020;59(7):927-939. PubMed
Rauwolscine 28 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Teloken C, Rhoden EL, Sogari P, et al. Therapeutic effects of high dose yohimbine hydrochloride on organic erectile dysfunction. J Urol 1998;159:122-4. PubMed
- Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992;53:119-22.
- Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992;53:207-9.
- Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urol 1993;41:343-5. PubMed
- Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother 2010;44:1022-9. PubMed
- VandenBrink, B. M., Foti, R. S., Rock, D. A., Wienkers, L. C., and Wahlstrom, J. L. Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition. Drug Metab Dispos. 2012;40(1):47-53. PubMed
- Mustonen, P., Savola, J., and Lassila, R. Atipamezole, an imidazoline-type alpha(2)-adrenoceptor inhibitor, binds to human platelets and inhibits their adrenaline-induced aggregation more effectively than yohimbine. Thromb.Res 8-1-2000;99(3):231-237.
- Bagheri, H., Schmitt, L., Berlan, M., and Montastruc, J. L. Effect of 3 weeks treatment with yohimbine on salivary secretion in healthy volunteers and in depressed patients treated with tricyclic antidepressants. Br J Clin Pharmacol 1992;34(6):555-558. PubMed
- Swann, A. C., Birnbaum, D., Jagar, A. A., Dougherty, D. M., and Moeller, F. G. Acute yohimbine increases laboratory-measured impulsivity in normal subjects. Biol.Psychiatry 5-15-2005;57(10):1209-1211. PubMed
- Adeniyi, A. A., Brindley, G. S., Pryor, J. P., and Ralph, D. J. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl 2007;9(3):403-407. PubMed
- Giampreti, A., Lonati, D., Locatelli, C., Rocchi, L., and Campailla, M. T. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol.(Phila) 2009;47(8):827-829. PubMed
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