Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Zelac Probiotic Support Ingredients & Drug Interactions

by Foxland Pharmaceuticals

Zelac Probiotic Support label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zelac Probiotic Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zelac Probiotic Support is a dietary supplement by Foxland Pharmaceuticals with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zelac Probiotic Support by Foxland Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Zelac Probiotic Support by Foxland Pharmaceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zelac Probiotic Support by Foxland Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.

Zelac Probiotic Support contains 2 active ingredients: Lactobacillus acidophilus and Bifidobacterium animalis lactis — both live-culture probiotics. The product also has several inactive ingredients (gelatin, microcrystalline cellulose, maltodextrin, magnesium stearate, and silica) that serve as the capsule and filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Lactobacillus Acidophilus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Lactobacillus Acidophilus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

Lactobacillus acidophilus is rated possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's rated possibly ineffective for atopic disease (allergic conditions).

For acute respiratory distress syndrome, there isn't enough reliable evidence to rate it. We have no effectiveness data on file for Bifidobacterium animalis lactis in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. In rare cases, because these are live organisms, there's a theoretical concern they could cause serious infections — cases of bacteremia, sepsis, endocarditis, and other severe infections have been documented, though most occurred when bacteria migrated from places where they naturally occur in the body.

Gastrointestinal side effects like abdominal pain, bloating, flatulence, and diarrhea are uncommon but possible. In one trial, rash and itching were reported, though it's unclear whether they were due to this ingredient or something else.

For pregnancy, Lactobacillus acidophilus is rated possibly safe. We have no pregnancy or lactation data on file for Bifidobacterium animalis lactis.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern: taking them at the same time as this product may reduce how well the probiotic works. Your doctor or pharmacist can advise you on spacing doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with IBS, antibiotic-associated diarrhea, or certain infections if you're looking for probiotic support. If you take antibiotics, talk with your doctor or pharmacist about timing this supplement so it works better — and mention any other health conditions before starting.

Since these are live organisms, your provider should know your full health picture before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zelac Probiotic Support, straight from the product label.

Brand Foxland Pharmaceuticals
Barcode (UPC) 369067070303
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 263541
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zelac Probiotic Support by Foxland Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
369067070303
IngredientAmount% DV
Lactobacillus acidophilus0 NP--
Bifidobacterium animalis lactis0 NP--

Other ingredients: Gelatin, Microcrystalline Cellulose, Maltodextrin, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Dosage: Usual adult dose is 1 capsule once or twice daily, or as prescribed by a licensed medical practitioner.

Precautions

If you are pregnant or nursing, ask a healthcare professional.

Zelac should be administered under the supervision of a licensed medical practitioner.

Keep out of reach of children

Storage

Storage: Store at 20 degrees-25 degrees C (68 degrees-77 degrees F); excursions permitted to 15 degrees-30 degrees C (59 degrees-86 degrees F) [See USP controlled room temperature.]

General Statements

69067-070-30

Formula

Lactobacillus acidophilus Bifidobacterium lactis

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zelac Probiotic Support by Foxland Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zelac Probiotic Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zelac Probiotic Support by Foxland Pharmaceuticals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactobacillus acidophilus

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus acidophilus monograph & interactions

Bifidobacterium animalis lactis

0 NP per serving

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Maltodextrin, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zelac Probiotic Support by Foxland Pharmaceuticals Drug Interactions

Want to check YOUR meds against Zelac Probiotic Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Zelac Probiotic Support interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Zelac Probiotic Support interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Zelac Probiotic Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zelac Probiotic Support, from the product label.

Foxland Pharmaceuticals

See all Foxland Pharmaceuticals products
Name
Foxland Pharmaceuticals, Inc.
City
Trussville
State
AL
ZipCode
35173
Pharmacist Counseling Corner

Zelac Probiotic Support by Foxland Pharmaceuticals: Common Questions

Does Zelac Probiotic Support by Foxland Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, Zelac Probiotic Support has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zelac Probiotic Support contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on an antibiotic?
You can, but timing matters. Antibiotics kill off the live organisms in probiotics, so they work better when taken several hours apart. Ask your doctor or pharmacist how to space them for your specific antibiotic.
What's Lactobacillus acidophilus supposed to do?
It's a probiotic — a live beneficial bacterium that may help with irritable bowel syndrome, antibiotic-associated diarrhea, certain infections, and bacterial vaginosis. The evidence is promising but not yet conclusive for all those uses.
Will this cause stomach upset?
Uncommon, but possible — some people report bloating, gas, abdominal pain, or diarrhea when taking probiotic combinations. These effects are usually mild and tend to settle. If they don't, mention it to your pharmacist.
Is this safe during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy. However, talk with your doctor before starting any new supplement while pregnant — they know your full health picture and can give personalized guidance.
What's the difference between the two probiotics in this product?
Both are live-culture probiotics meant to support gut health. Lactobacillus acidophilus has research backing several uses; we have no effectiveness data on file for Bifidobacterium animalis lactis in this product specifically.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zelac Probiotic Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zelac Probiotic Support label
Go deeper

The Full Monographs Behind Zelac Probiotic Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Zelac Probiotic Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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