Reishi Mushroom - Pletal (Cilostazol) Interaction
Herbal: Reishi Mushroom
Also Known As: Ganoderma lucidum, Basidiomycetes Mushroom, Champignon Reishi, Champignons Reishi, Ganoderma, Hongo Reishi, Ling Chih, Ling Zhi, Lingzh, Mannentake, Mushroom, Mushroom of Immortality, Red Reishi, Reishi, Reishi Antler Mushroom, Reishi Rouge, Rei-Shi, Spirit Plant
Drug: Cilostazol
Brand names:
Pletal
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Apr 13, 2025
Interaction Details
Cilostazol is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3.
- Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6.
Reishi Mushroom Overview
Reishi mushroom (Ganoderma lucidum) is a type of mushroom native to Asia. It is a relatively tough mushroom with a shiny, reddish-brown exterior and a bitter, woody taste.
Reishi mushroom is popular in traditional medicine, with a history of use dating back several thousand years. It is purported to have a number of health benefits, including the ability to boost the immune system, reduce inflammation, and improve overall well-being.
Cilostazol Overview
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Cilostazol is used to reduce the symptoms of intermittent claudication (pain in the legs that worsens when walking and improves when resting that is caused by narrowing of the blood vessels that supply blood to the legs). Cilostazol is in a class of medications called platelet-aggregation inhibitors (antiplatelet medications). It works by improving blood flow to the legs.
Reishi Mushroom - More Interactions
Reishi Mushroom interacts with 369 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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