Aluminum Hydroxide

58 interactions 1 explained in plain English

Also sold as: AlternaGEL® Alu-Cap® Alu-Tab® Amphojel® Derma Gran

About Aluminum Hydroxide

An antacid that relieves heartburn, sour stomach, and ulcer pain while helping ulcers heal. Read the full Aluminum Hydroxide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Octreotide Octreotide Injection Cefuroxime Deferasirox Digoxin Hydroxychloroquine

15 Major 36 Moderate 7 Minor

All (58) Major (15) Moderate (36) Minor (7)

Major

Aluminum Hydroxide Acalabrutinib Calquence Reduced acalabrutinib exposure Details Aluminum Hydroxide Cabotegravir Apretude Reduced cabotegravir plasma concentrations Details Aluminum Hydroxide Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Aluminum Hydroxide Deferasirox Exjade Decreased deferasirox effectiveness Details Aluminum Hydroxide Digoxin Cardoxin® Reduced digoxin exposure Details Aluminum Hydroxide Erdafitinib Balversa Altered serum phosphate levels Details Aluminum Hydroxide Ezetimibe Zetia Reduced ezetimibe exposure Details Aluminum Hydroxide Gefitinib Iressa Decreased exposure of gefitinib Details Aluminum Hydroxide Hydroxychloroquine Plaquenil Reduced hydroxychloroquine exposure Details Aluminum Hydroxide Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Aluminum Hydroxide Ketoconazole Topical Extina® Foam Reduced ketoconazole exposure and reduced efficacy of ketoconazole Details Aluminum Hydroxide Mefenamic Acid Ponstel® Increased exposure to mefenamic acid Details Aluminum Hydroxide Neratinib Nerlynx Decreased neratinib exposure Details Aluminum Hydroxide Octreotide Bynfezia Decreased octreotide bioavailability Details Aluminum Hydroxide Octreotide Injection Bynfezia Decreased octreotide bioavailability Details

Moderate

Aluminum Hydroxide Allopurinol Aloprim Decreased allopurinol effectiveness Details Aluminum Hydroxide Allopurinol Injection Aloprim Decreased allopurinol effectiveness Details Aluminum Hydroxide Aspirin Acuprin® Decreased salicylate effectiveness Details Aluminum Hydroxide Aspirin Rectal Aspirin Decreased salicylate effectiveness Details Aluminum Hydroxide Bosutinib Bosulif Reduced bosutinib exposure Details Aluminum Hydroxide Captopril Capoten® Decreased captopril effectiveness Details Aluminum Hydroxide Cefdinir Omnicef® Decreased cefdinir efficacy Details Aluminum Hydroxide Cefpodoxime Banan® Decreased cefpodoxime effectiveness Details Aluminum Hydroxide Chloroquine Aralen® Decreased efficacy of chloroquine Details Aluminum Hydroxide Dasatinib Phyrago Reduced dasatinib exposure Details Aluminum Hydroxide Deflazacort Emflaza Decreased deflazacort effectiveness Details Aluminum Hydroxide Demeclocycline Declomycin® Reduced efficacy of tetracyclines Details Aluminum Hydroxide Doxycycline Injection Acticlate Reduced efficacy of tetracyclines Details Aluminum Hydroxide Erlotinib Tarceva Reduced erlotinib exposure Details Aluminum Hydroxide Ethambutol Myambutol Decreased ethambutol serum concentrations Details Aluminum Hydroxide Fexofenadine Allegra Decreased fexofenadine efficacy Details Aluminum Hydroxide Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Aluminum Hydroxide Gatifloxacin Ophthalmic Zymar® Loss of gatifloxacin efficacy Details Aluminum Hydroxide Gemifloxacin Factive Decreased oral gemifloxacin effectiveness Details Aluminum Hydroxide Ibandronate Boniva Decreased ibandronate effectiveness Details Aluminum Hydroxide Ibandronate Injection Boniva Decreased ibandronate effectiveness Details Aluminum Hydroxide Levofloxacin Levaquin Decreased oral levofloxacin effectiveness Details Aluminum Hydroxide Levofloxacin Injection Levaquin Decreased oral levofloxacin effectiveness Details Aluminum Hydroxide Levothyroxine Ermeza Reduced efficacy of levothyroxine Details Aluminum Hydroxide Mesalamine Apriso Alteration of mesalamine bioavailability Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.