Amantadine

22 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Diphenhydramine Injection Hydromorphone Injection Trospium / Xanomeline Glucagon Nasal Powder Morphine Injection
22 Major
All (22) Major (22)

Major

Amantadine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Amantadine Amitriptyline Elavil Explained Potentiation of anticholinergic effects Details Amantadine Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Amantadine Trospium / Xanomeline Cobenfy Explained Potentiation of anticholinergic effects Details Amantadine Aclidinium Oral Inhalation Tudorza Potentiation of anticholinergic effects Details Amantadine Atropine Ophthalmic Atropine Care 1% Potentiation of anticholinergic effects Details Amantadine Cyclopentolate Ophthalmic Akpentolate® Potentiation of anticholinergic effects Details Amantadine Diphenhydramine Injection Banophen Potentiation of anticholinergic effects Details Amantadine Diphenhydramine Topical Afterbite with Antihistamine Potentiation of anticholinergic effects Details Amantadine Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Amantadine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Amantadine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Amantadine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Amantadine Glycopyrronium Topical Cuvposa® Potentiation of anticholinergic effects Details Amantadine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Amantadine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Amantadine Ipratropium Nasal Spray Atrovent Nasal Spray® Potentiation of anticholinergic effects Details Amantadine Ipratropium Oral Inhalation Atrovent® HFA Potentiation of anticholinergic effects Details Amantadine Memantine Namenda Increased adverse events of N-methyl-D-aspartate antagonists Details Amantadine Metoclopramide Injection Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Amantadine Metoclopramide Nasal Spray Gimoti Diminished effectiveness of metoclopramide and the dopaminergic agent Details Amantadine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.