Bosutinib

164 interactions 1 explained in plain English 321 cited references

Also sold as: Bosulif Bosulif®

About Bosutinib

Bosutinib is used to treat a certain type of chronic myeloid leukemia (CML; a type of cancer of the white blood cells), including treatment in adults who have been recently found to have this condition and in those who can no longer benefit from other medications for CML or who cannot take these medications because of… Read the full Bosutinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bacillus Of Calmette And Guerin Vaccine, Live Mumps Virus Vaccine, Live Mifepristone Measles Virus Vaccine, Live Ensitrelvir Dengue Tetravalent Vaccine, Live

11 Contraindicated 125 Major 28 Moderate

All (164) Contraindicated (11) Major (125) Moderate (28)

Contraindicated

Bosutinib Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Bosutinib Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Bosutinib Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Bosutinib Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bosutinib Mifepristone Korlym Increased CYP3A4 substrate with NTI exposure Details Bosutinib Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bosutinib Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bosutinib Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Bosutinib Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Bosutinib Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Bosutinib Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Bosutinib Omeprazole Gastrobim Reduced bosutinib exposure Details Bosutinib Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Bosutinib Adagrasib Krazati Increased CYP3A4 substrate exposure Details Bosutinib Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Bosutinib Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Bosutinib Amprenavir Increased bosutinib exposure Details Bosutinib Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Bosutinib Aprepitant Aponvie Increased bosutinib exposure Details Bosutinib Atazanavir Reyataz Increased bosutinib exposure Details Bosutinib Avacopan Tavneos Increased exposure to CYP3A4 substrate Details Bosutinib Belzutifan Welireg Reduced CYP3A4 substrates with NTI exposure and reduced efficacy of CYP3A4 substrates with NTI Details Bosutinib Berotralstat Orladeyo Increased CYP3A4 substrate exposure and an increased CYP3A4 substrate-related adverse reactions Details Bosutinib Boceprevir Increased bosutinib exposure Details Bosutinib Carbamazepine Carbatrol Reduced bosutinib exposure and reduced efficacy of bosutinib Details Bosutinib Ceritinib Zykadia Increased exposure of CYP3A substrate Details Bosutinib Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Bosutinib Cimetidine Tagamet Increased or reduced bosutinib exposure Details Bosutinib Ciprofloxacin Increased bosutinib exposure Details Bosutinib Clarithromycin Biaxin Increased bosutinib exposure Details Bosutinib Clofazimine Increased bosutinib exposure Details Bosutinib Cobicistat Tybost Increased bosutinib exposure Details Bosutinib Conivaptan Vaprisol Increased CYP3A substrate exposure Details Bosutinib Crizotinib Xalkori Increased bosutinib exposure Details Bosutinib Cyclosporine Atopica Increased bosutinib exposure Details Bosutinib Dabrafenib Tafinlar Reduced sensitive CYP3A4 substrate exposure Details Bosutinib Daridorexant Increased CYP3A4 substrate with NTI exposure Details Bosutinib Darunavir Increased bosutinib exposure Details Bosutinib Dexlansoprazole Dexilant Reduced bosutinib exposure Details Bosutinib Diltiazem Cardizem Increased bosutinib exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.