Chloral Hydrate
39 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Acetaminophen And Codeine
Dofetilide
Octreotide Injection
Arsenic Trioxide
Morphine Injection
Butorphanol Injection
Major
Chloral Hydrate Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Chloral Hydrate Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Chloral Hydrate Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Chloral Hydrate Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Chloral Hydrate Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Chloral Hydrate Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Chloral Hydrate Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Diazepam Nasal Spray Valtoco Additive respiratory depression Details Chloral Hydrate Diazepam Rectal Diastat Additive respiratory depression Details Chloral Hydrate Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Dofetilide Tikosyn Cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Esketamine Nasal Spray Spravato Increased risk of sedation Details Chloral Hydrate Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Chloral Hydrate Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Furosemide Injection Disal An increased risk of flushing, sweating attacks, restlessness, nausea and an increased blood pressure and tachycardia Details Chloral Hydrate Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Chloral Hydrate Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Chloral Hydrate Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Lacosamide Injection Motpoly An increased risk of CNS depression Details Chloral Hydrate Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Chloral Hydrate Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Methotrexate Jylamvo Increased methotrexate exposure Details Chloral Hydrate Methotrexate Injection Abitrexate® Increased methotrexate exposure Details Chloral Hydrate Metoclopramide Injection Gimoti Increased risk of CNS depression Details Chloral Hydrate Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Chloral Hydrate Midazolam Nasal Spray Nayzilam Additive respiratory depression Details Chloral Hydrate Midazolam Injection Nayzilam Additive respiratory depression Details Chloral Hydrate Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Chloral Hydrate Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Chloral Hydrate Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Chloral Hydrate Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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