Fosinopril

193 interactions 566 cited references
Also sold as: Monopril®
About Fosinopril

Fosinopril is an ACE inhibitor used to treat high blood pressure and heart failure. Read the full Fosinopril drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fosinopril Aspirin Acuprin® Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Fosinopril Aspirin Rectal Aspirin Reduced hyponatremic and hypotensive effects of ACE inhibitors Details Fosinopril Azathioprine Azasan Myelosuppression Details Fosinopril Azilsartan Edarbi Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Fosinopril Cyclosporine Injection Atopica Acute renal dysfunction and an increased risk of hyperkalemia Details Fosinopril Cyclosporine Ophthalmic Cequa Acute renal dysfunction and an increased risk of hyperkalemia Details Fosinopril Digoxin Cardoxin® An increased digoxin exposure Details Fosinopril Eprosartan Teveten® Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Fosinopril Everolimus Afinitor Increased risk of angioedema Details Fosinopril Alteplase, Recombinant Activase An increased risk of orolingual angioedema Details Fosinopril Amiloride Increased risk of hyperkalemia Details Fosinopril Azilsartan Medoxomil Edarbi Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Fosinopril Candesartan Atacand Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Fosinopril Canrenoate Increased risk of hyperkalemia Details Fosinopril Cyclosporine Atopica Acute renal dysfunction and an increased risk of hyperkalemia Details Fosinopril Eplerenone Inspra Increased risk of hyperkalemia Details Fosinopril Furosemide Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Fosinopril Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Fosinopril Irbesartan Avapro Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Fosinopril Lithium Increased risk of lithium toxicity Details Fosinopril Losartan Arbli Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Fosinopril Melphalan Alkeran An increased risk of severe hypotension Details Fosinopril Mercaptopurine Purinethol® Myelosuppression Details Fosinopril Olmesartan Benicar Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Fosinopril Potassium Glu-K® Hyperkalemia Details Fosinopril Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Fosinopril Potassium Phosphate K-Phos Increased risk of severe and potentially fatal hyperkalemia Details Fosinopril Pregabalin Bonqat Increased risk of angioedema Details Fosinopril Sirolimus Felycin Increased risk of angioedema Details Fosinopril Spironolactone Aldactone Increased risk of hyperkalemia Details Fosinopril Tacrolimus Astagraf An increased risk of hyperkalemia Details Fosinopril Telmisartan Micardis Increased risk of adverse events (ie, hypotension, syncope, hyperkalemia, changes in renal function, acute renal failure) Details Fosinopril Temsirolimus Torisel Increased risk of angioedema Details Fosinopril Triamterene Dyrenium Increased risk of hyperkalemia Details Fosinopril Trimethoprim Primsol Increased risk of hyperkalemia Details Fosinopril Furosemide Injection Disal An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Fosinopril Lithium Carbonate Lithobid Increased risk of lithium toxicity Details

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