Nefazodone

147 interactions 10 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Contraindicated

Nefazodone Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of fatal toxicity Details Nefazodone Simvastatin Flolipid Explained An increased risk of myopathy or rhabdomyolysis Details Nefazodone Dihydroergotamine Injection DHE-45® Injection Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Nefazodone Dihydroergotamine Nasal Spray Migranal Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Nefazodone Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Nefazodone Ivabradine Corlanor Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Nefazodone Lovastatin Altocor® Increased lovastatin exposure and an increased risk of lovastatin-related adverse effects, such as, risk of myopathy or rhabdomyol... Details Nefazodone Lurasidone Latuda Increased lurasidone exposure Details Nefazodone Methylergonovine Methergine Increased ergot derivatives exposure and an increased risk of ergotism (nausea, vomiting, vasospastic ischemia) Details Nefazodone Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Nefazodone Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Nefazodone Naloxegol Movantik Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Nefazodone Nimodipine Nimotop Increased serum nimodipine concentrations Details

Major

Nefazodone Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure and an increased risk of serotonin syndrome Details Nefazodone Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Nefazodone Sertraline Explained An increased risk of serotonin syndrome Details Nefazodone Buprenorphine Belbuca Explained An increased risk of serotonin syndrome, increased buprenorphine exposure and an increased risk of buprenorphine-related adverse e... Details Nefazodone Relugolix Orgovyx Explained Increased relugolix exposure Details Nefazodone Acalabrutinib Calquence Increased acalabrutinib exposure Details Nefazodone Ado-Trastuzumab Emtansine Injection KADCYLA Increased exposure of cytotoxic component DM1 (maytansine derivative) and risk of toxicity Details Nefazodone Apixaban Eliquis Explained Increased apixaban exposure and an increased risk of bleeding and can cause serious, potentially fatal bleeding Details Nefazodone Aripiprazole Injection Abilify Increased ARIPiprazole exposure Details Nefazodone Asciminib Scemblix Increased asciminib exposure and an increased risk of asciminib-related adverse effects Details Nefazodone Aspirin Acuprin® An increased risk of bleeding Details Nefazodone Aspirin Rectal Aspirin An increased risk of bleeding Details Nefazodone Atogepant Qulipta Increased atogepant exposure Details Nefazodone Avapritinib Ayvakit Increased avapritinib exposure and increased incidence and severity of adverse reactions Details Nefazodone Azathioprine Azasan An increased risk of hepatotoxicity Details Nefazodone Atorvastatin Atorvaliq An increased risk of myopathy or rhabdomyolysis Details Nefazodone Cariprazine Vraylar Explained Increased exposure to cariprazine and its active metabolite, didesmethylcariprazine Details Nefazodone Amlodipine Amvaz® Increased amLODIPine exposure and an increased risk of hypotension and edema Details Nefazodone Avanafil Stendra Decreased avanafil clearance and increased avanafil plasma concentrations Details Nefazodone Axitinib Inlyta Increased axitinib plasma concentrations Details Nefazodone Beclomethasone Nasal Spray Beconase Increased beclomethasone exposure and an increased risk of beclomethasone-related adverse reactions Details Nefazodone Beclomethasone Oral Inhalation Beclovent® Increased beclomethasone exposure and an increased risk of beclomethasone-related adverse reactions Details Nefazodone Bedaquiline Sirturo Increased bedaquiline exposure Details Nefazodone Bosutinib Bosulif Increased bosutinib exposure Details Nefazodone Brentuximab Vedotin Injection Adcetris Increased exposure to active entity of brentuximab vedotin Details Nefazodone Brexpiprazole Rexulti Increased brexpiprazole exposure Details Nefazodone Brigatinib Alunbrig Increased brigatinib exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.