Oxymorphone

45 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Oxymorphone Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxymorphone Amitriptyline Elavil Explained Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Oxymorphone Sertraline Explained Increased risk of serotonin syndrome Details Oxymorphone Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Oxymorphone Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxymorphone Aripiprazole Injection Abilify Increased risk of respiratory and CNS depression Details Oxymorphone Asenapine Transdermal Patch Secuado Increased risk of respiratory and CNS depression Details Oxymorphone Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxymorphone Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxymorphone Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Oxymorphone Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms and an increased risk of serotonin syndrome Details Oxymorphone Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Oxymorphone Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Oxymorphone Clopidogrel Plavix Reduced efficacy of clopidogrel Details Oxymorphone Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxymorphone Diazepam Nasal Spray Valtoco Increased risk of respiratory and CNS depression Details Oxymorphone Diazepam Rectal Diastat Increased risk of respiratory and CNS depression Details Oxymorphone Diphenhydramine Injection Banophen Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Oxymorphone Diphenhydramine Topical Afterbite with Antihistamine Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Oxymorphone Dolasetron Anzemet Increased risk of serotonin syndrome Details Oxymorphone Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Oxymorphone Esketamine Nasal Spray Spravato Increased risk of sedation Details Oxymorphone Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxymorphone Furosemide Injection Disal Reduced efficacy of diuretics Details Oxymorphone Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxymorphone Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Oxymorphone Granisetron Injection Granisol Increased risk of serotonin syndrome Details Oxymorphone Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxymorphone Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Oxymorphone Hydroxychloroquine Plaquenil An increased risk of seizures Details Oxymorphone Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxymorphone Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Oxymorphone Lacosamide Injection Motpoly An increased risk of CNS depression Details Oxymorphone Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Oxymorphone Linezolid Injection Zyvox Increased risk of serotonin syndrome or opioid toxicity Details Oxymorphone Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Oxymorphone Metoclopramide Injection Gimoti Increased risk of CNS depression Details Oxymorphone Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Oxymorphone Midazolam Nasal Spray Nayzilam Increased risk of respiratory and CNS depression Details Oxymorphone Midazolam Injection Nayzilam Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.