Drug & supplement interaction

Apple + Glycerol Phenylbutyrate

Glycerol Phenylbutyrate brand name: Ravicti.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Apple and Glycerol Phenylbutyrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Glycerol Phenylbutyrate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Apple and Glycerol Phenylbutyrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glycerol Phenylbutyrate and Apple in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Apple safety at a glance

Apple overall Generally safe Apples as a food are safe for most people when eaten in normal amounts.
Pregnancy Generally safe Apples eaten as food are considered safe in pregnancy, but concentrated extracts are not well studied.
Breastfeeding Generally safe Apples as a food are considered safe while breastfeeding; supplements are not well studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glycerol Phenylbutyrate and Apple? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Glycerol Phenylbutyrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Glycerol Phenylbutyrate is filed under a single classification — oral drugs. Apple has documented interactions with 7 drug classes — the most serious being organic anion-transporting polypeptide substrates (oatp) (major), aliskiren (tekturna, rasilez) (moderate) and antidiabetes drugs (moderate) — and none of Glycerol Phenylbutyrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Apple Does Interact With Other Medications

Apple has 47 major, 253 moderate known drug interactions in our database — Glycerol Phenylbutyrate isn’t one of them. If you take anything else, check it against the full list below.

Major 47 Moderate 253 No known interaction 2,530 (incl. Glycerol Phenylbutyrate)
Taking anything else?

Check Another of Your Medications Against Apple

Covers the 2,830 medications we’ve checked against Apple. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Apple and Glycerol Phenylbutyrate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas Additional detail

    Apple

    “Orally, apple products, including whole apples, apple puree, and apple juice, may cause bloating and flatulence in some people.”

    Apple · Natural Medicines adverse-effect record, reported in flatulence.

    1 source cited
    1. 104184. Krishnasamy S, Lomer MCE, Marciani L, et al. Processing apples to puree or juice speeds gastric emptying and reduces postprandial intestinal volumes and satiety in healthy adults. J Nutr 2020;150(11):2890-9. PubMed

    Glycerol Phenylbutyrate

    Listed in the ADVERSE REACTIONS section of the FDA label for Glycerol Phenylbutyrate. Read the label on DailyMed ›

Reported for Apple but not commonly for Glycerol Phenylbutyrate: an allergic reaction and a severe allergic reaction.

Effects for Glycerol Phenylbutyrate come from the ADVERSE REACTIONS section of its FDA label; effects for Apple come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,358 voluntary FDA FAERS reports for Glycerol Phenylbutyrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Glycerol Phenylbutyrate Products Have a Food Rule — Apple Should Not Break It

At least one FDA label for a product containing Glycerol Phenylbutyrate says to take it with food. If you take Apple on an empty stomach out of habit, keep them separate — and take Glycerol Phenylbutyrate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Glycerol Phenylbutyrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Instruct patients to take glycerol phenylbutyrate oral liquid with food or formula and to administer directly into the mouth via oral syringe.

From the Dosage and Administration section of the FDA label we read for Glycerol Phenylbutyrate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Apple or Glycerol Phenylbutyrate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Apple or Glycerol Phenylbutyrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Glycerol Phenylbutyrate

This page covers Apple only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glycerol Phenylbutyrate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Glycerol Phenylbutyrate page

“Ravicti (glycerol phenylbutyrate) pulls ammonia out of the blood in people with urea cycle disorders, so a dose that never gets absorbed is not a small problem, it can let ammonia climb toward dangerous levels. That is why this list deserves real attention even though it is short.”

Reviewed by 2 · Jul 18, 2026

Open the Glycerol Phenylbutyrate interaction page

One more smart check

Taking Apple as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2,841 real supplement products containing Apple, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Apple. Even though Apple itself has no known interaction with Glycerol Phenylbutyrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Apple and Glycerol Phenylbutyrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Apple
Top 10%

#106 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glycerol Phenylbutyrate
Top half

#949 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Apple reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Apple and Glycerol Phenylbutyrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Apple

What is Apple?

Apple
  • General nutrition and fiber intake
  • Heart and cholesterol health
  • Blood sugar and weight management
  • Digestive regularity
  • Antioxidant support

Apples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into a healthy diet. While research suggests apples may support heart and digestive health, most claims about concentrated apple supplements or extracts are not strongly proven, so enjoy apples as food and talk with your pharmacist before using high-dose products.

Malus domestica · Rosaceae · Fruit (with peel), and sometimes the peel, pectin (fiber), juice, and cider vinegar · Fresh fruit, juice, dried fruit, applesauce, apple cider vinegar, pectin supplements, polyphenol extracts

An interaction check asks whether these two react with each other — it does not ask whether Apple is a good idea for someone in your situation. Here is what our Apple record says about it on its own.

Apple: dosing

There is no official medicinal dose for apples because they are a food rather than a drug. As part of a healthy diet, eating one or more whole apples per day is a reasonable goal for most people.For apple supplements such as pectin, polyphenol extracts, or apple cider vinegar products, there is no established standardized dose.

From our Apple monograph — the full record covers uses, side effects and every documented interaction.

Read the full Apple monograph & all interactions
Medication

About Glycerol Phenylbutyrate

What Is Glycerol Phenylbutyrate Used For?

Brand name: Ravicti

Glycerol phenylbutyrate oral liquid — available as the brand Ravicti and as a generic — is used for the long-term (chronic) management of urea cycle disorders (UCDs). UCDs are rare inherited conditions where the body cannot properly convert ammonia into urea, causing toxic ammonia levels to build up in the blood and brain.

It is used in patients whose ammonia cannot be controlled by a low-protein diet and/or amino acid supplements alone. It must always be used alongside dietary protein restriction and, in some cases, additional dietary supplements such as essential amino acids, arginine, or citrulline. It is not for treating a sudden, severe spike in ammonia (acute hyperammonemia), and its safety and effectiveness for N-acetylglutamate synthase (NAGS) deficiency have not been established.

Most-Reported Side Effects for Glycerol Phenylbutyrate

From FAERS, the FDA’s public side-effect reporting system (1,358 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Ammonia increased 197 reports
Vomiting 165 reports
Hyperammonaemia 158 reports
Decreased appetite 104 reports
Nausea 74 reports
See full Glycerol Phenylbutyrate drug information
Keep checking

Other Drugs & Apple

Browse every other medication we’ve checked against Apple — both the ones with a known interaction and the ones without. Select any drug for the full detail.

47Major
253Moderate
0Minor
2,529No known interaction
47 Major 253 Moderate 2,529 No interaction
Major

47 interactions

Moderate

253 interactions

Showing 60 of 253 moderate interactions — see all 253 on the Apple page.

No interaction 2,529 drugs checked — show the list

We also checked Apple against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,529 medications checked with no known interaction — see the full Apple list.

See the full Apple interactions page
See every supplement checked against Glycerol Phenylbutyrate, ranked by severity
Evidence & sources

Apple References

The 16 references that drive our Apple monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
  3. Rodriguez J, Crespo JF, Lopez-Rubio A, et al. Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol 2000;106:183-189. PubMed
  4. Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
  5. Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
  6. Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed
  7. Tapaninen T, Neuvonen PJ, Niemi M. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol 2011;71:718-26. PubMed
  8. Jeon H, Jang IJ, Lee S, et al. Apple juice greatly reduces systemic exposure to atenolol. Br J Clin Pharmacol 2012 May 11. doi: 10.1111/j.1365-2125.2012.04324.x. [Epub ahead of print]. PubMed
  9. Visvanathan, R., Chen, R., Horowitz, M., and Chapman, I. Blood pressure responses in healthy older people to 50 g carbohydrate drinks with differing glycaemic effects. Br J Nutr 2004;92(2):335-340. PubMed
  10. Asp, N. G., Agardh, C. D., Ahren, B., Dencker, I., Johansson, C. G., Lundquist, I., Nyman, M., Sartor, G., and Schersten, B. Dietary fibre in type II diabetes. Acta Med Scand Suppl 1981;656:47-50. PubMed
  11. Akamine Y, Miura M, Komori H, et al. Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers. Eur J Clin Pharmacol. 2014 Sep;70(9):1087-95. PubMed
  12. Luo J, Imai H, Ohyama T, et al. The Pharmacokinetic Exposure to Fexofenadine is Volume-Dependently Reduced in Healthy Subjects Following Oral Administration With Apple Juice. Clin Transl Sci. 2016 Aug;9(4):201-6. PubMed
  13. Tsiougkos N, Vovolis V. Repeated anaphylactic episodes to orange and apple. Eur Ann Allergy Clin Immunol. 2013 May;45(3):113-5.
  14. Rubido S, García-Caballero L, Abeleira MT, Limeres J, García M, Diz P. Effect of chewing an apple on dental plaque removal and on salivary bacterial viability. PLoS One. 2018;13(7):e0199812. PubMed
  15. Krishnasamy S, Lomer MCE, Marciani L, et al. Processing apples to puree or juice speeds gastric emptying and reduces postprandial intestinal volumes and satiety in healthy adults. J Nutr 2020;150(11):2890-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Apple and Glycerol Phenylbutyrate Together: Common Questions

Is it safe to take Apple with Glycerol Phenylbutyrate?
We do not list a known interaction between Apple and Glycerol Phenylbutyrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Apple and Glycerol Phenylbutyrate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Apple and Glycerol Phenylbutyrate at the same time of day?
At least one FDA label for a product containing Glycerol Phenylbutyrate says to take it with food. If you take Apple on an empty stomach out of habit, keep them separate and take Glycerol Phenylbutyrate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Glycerol Phenylbutyrate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Apple and Glycerol Phenylbutyrate combination checked?
Interactions in our licensed database are recorded against drug classes. Glycerol Phenylbutyrate is filed under 1 classification, and Apple has documented interactions with 7 drug classes — none of Glycerol Phenylbutyrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Apple interact with any other medications?
Yes. Apple has 300 documented drug interactions in our database — Glycerol Phenylbutyrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Glycerol Phenylbutyrate interact with any supplements?
Yes. Glycerol Phenylbutyrate has documented interactions with 17 supplements in our database — Apple is not one of them. The Glycerol Phenylbutyrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Apple monograph Uses, safety profile, and every drug interaction in one place Glycerol Phenylbutyrate drug information The full plain-English guide to this medication Glycerol Phenylbutyrate supplement interactions Every supplement checked against Glycerol Phenylbutyrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 16 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glycerol Phenylbutyrate and Apple?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.