Drug & supplement interaction

Atractylodes + Miconazole, Zinc Oxide, Petrolatum

Miconazole, Zinc Oxide, Petrolatum brand name: Vusion.

Minor Interaction
Medically reviewed by · Updated October 2026
The bottom line Minor

Atractylodes has a minor interaction with Miconazole, Zinc Oxide, Petrolatum. Theoretically, atractylodes might increase the levels of CYP3A4 substrates.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Atractylodes and Miconazole, Zinc Oxide, Petrolatum

Here is the interaction we found between these two, with the evidence behind it.

Minor

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

Why this applies to Miconazole, Zinc Oxide, Petrolatum

Miconazole, Zinc Oxide, Petrolatum falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Atractylodes interacts with.

Theoretically, atractylodes might increase the levels of CYP3A4 substrates.
In animals, atractylodes administered at high doses has been shown to inhibit CYP3A1 activity, which is a homolog to the human CYP3A4 enzyme. This effect has not been shown in humans.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's some good news that should put your mind at ease. The product you're asking about (Vusion) is a diaper rash cream you spread on the skin. Miconazole fights yeast, while zinc oxide and petrolatum form a soothing, protective barrier. Because you apply it to the outside of the body, very little gets absorbed into the bloodstream.

The interaction on file is about atractylodes possibly slowing down the CYP3A4 enzyme that breaks down certain drugs. In theory that could let those drugs build up, but this was only seen in animals at high doses, never proven in people. For a topical cream like this, that liver enzyme barely matters. I wouldn't worry, but if you ever have questions, your pharmacist is happy to help.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Muhamad N, Plengsuriyakarn T, Na-Bangchang K. Atractylodes lancea for cholangiocarcinoma: Modulatory effects on CYP1A2 and CYP3A1 and pharmacokinetics in rats and biodistribution in mice. PLoS One 2022;17(11):e0277614. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Atractylodes Also Interacts With Other Medications

Atractylodes has 127 moderate, 675 minor known drug interactions in our database — the Miconazole, Zinc Oxide, Petrolatum one above is one of them. If you take anything else, check it against the full list below.

Moderate 127 Minor 675 No known interaction 2,028 (incl. Miconazole, Zinc Oxide, Petrolatum)
Taking anything else?

Check Another of Your Medications Against Atractylodes

Covers the 2,830 medications we’ve checked against Atractylodes. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Miconazole, Zinc Oxide, Petrolatum

This page covers Atractylodes only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Miconazole, Zinc Oxide, Petrolatum page lists 132 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 95 moderate · 35 minor.

From our pharmacist’s overview on the Miconazole, Zinc Oxide, Petrolatum page

“Grapefruit tops this list, with St. John's wort right beside it, the only two of 132 ingredients rated major against Vusion (miconazole, zinc oxide, and petrolatum), an antifungal ointment most often used for yeast-related diaper rash.”

Reviewed by 2 · Jul 18, 2026

Open the Miconazole, Zinc Oxide, Petrolatum interaction page

One more smart check

Taking Atractylodes as Part of a Dietary Supplement Product? Check It for Interactions

We hold 691 real supplement products containing Atractylodes, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Atractylodes. Your product may carry other ingredients that interact with Miconazole, Zinc Oxide, Petrolatum too, on top of Atractylodes — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Atractylodes and Miconazole, Zinc Oxide, Petrolatum Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Atractylodes
Top 25%

#238 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Miconazole, Zinc Oxide, Petrolatum
Top 25%

#408 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Atractylodes

What is Atractylodes?

Atractylodes
  • Digestive upset and poor appetite
  • Bloating and fluid retention
  • General fatigue or 'weakness'
  • Diarrhea
  • Support within traditional formulas

Atractylodes is a root used for centuries in traditional Chinese, Japanese, and Thai medicine, mostly for digestive complaints and fatigue, often as part of multi-herb formulas. Modern research is still early and mostly from lab and animal studies, so its true benefits in people are not well proven. If you want to try it, talk with a pharmacist or doctor first, and avoid it during pregnancy and breastfeeding.

Read the full Atractylodes monograph & all interactions
Keep checking

Other Drugs & Atractylodes

Browse every other medication we’ve checked against Atractylodes — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
127Moderate
675Minor
2,027No known interaction
127 Moderate 675 Minor 2,027 No interaction
Moderate

127 interactions

Showing 60 of 127 moderate interactions — see all 127 on the Atractylodes page.

Minor

675 interactions

Showing 60 of 675 minor interactions — see all 675 on the Atractylodes page.

No interaction 2,027 drugs checked — show the list

We also checked Atractylodes against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,027 medications checked with no known interaction — see the full Atractylodes list.

See the full Atractylodes interactions page
See every supplement checked against Miconazole, Zinc Oxide, Petrolatum, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Atractylodes monograph › Uses, safety, and every drug interaction in one place Miconazole, Zinc Oxide, Petrolatum supplement interactions › Every supplement checked against Miconazole, Zinc Oxide, Petrolatum, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Atractylodes and Miconazole, Zinc Oxide, Petrolatum Together: Common Questions

Can you take Atractylodes with Miconazole, Zinc Oxide, Petrolatum?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Atractylodes and Miconazole, Zinc Oxide, Petrolatum interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Miconazole, Zinc Oxide, Petrolatum and Atractylodes?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.