Drug & supplement interaction

Babassu + Pirfenidone

Pirfenidone brand name: Esbriet.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Babassu and Pirfenidone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Pirfenidone states a food rule worth keeping to.

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Interaction report

Babassu and Pirfenidone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pirfenidone and Babassu in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Babassu safety at a glance

Babassu overall Use caution It is used as a food and cosmetic, but human safety data for supplement use are limited.
Pregnancy Avoid There is not enough safety information, so it is best to avoid medicinal use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding has not been studied, so avoid medicinal use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pirfenidone and Babassu? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pirfenidone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pirfenidone is filed under 4 classifications — including cytochrome p450 1a2 (cyp1a2) substrates, cytochrome p450 1a2 (cyp1a2) substrates, photosensitizing drugs. Babassu has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and antithyroid drugs (moderate) — and none of Pirfenidone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Babassu Does Interact With Other Medications

Babassu has 127 moderate known drug interactions in our database — Pirfenidone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 127 No known interaction 2,703 (incl. Pirfenidone)
Taking anything else?

Check Another of Your Medications Against Babassu

Covers the 2,830 medications we’ve checked against Babassu. Pick one to open its full report.

What to actually watch for

What Pirfenidone’s Own FDA Label Lists

This is not an interaction — none of it involves Babassu. These are the most notable effects listed in the ADVERSE REACTIONS section of Pirfenidone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on
  • A higher chance of infection Worth acting on
  • Weight loss mentioned in 5.5% of FDA reports for Pirfenidone
  • Heartburn
  • Sun sensitivity
  • Reduced appetite mentioned in 8.1% of FDA reports for Pirfenidone
  • Bloating or gas
  • Joint pain
  • Trouble sleeping
  • Tiredness mentioned in 9.5% of FDA reports for Pirfenidone

Showing the 10 most notable of 18 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Pirfenidone. Read the label on DailyMed › Where a percentage is shown, it is the share of 40,089 voluntary FDA FAERS reports for Pirfenidone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Babassu’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Babassu side to compare — that is a limit of the record, not a statement that Babassu has no side effects.

How to take them

Some Pirfenidone Products Have a Food Rule — Babassu Should Not Break It

At least one FDA label for a product containing Pirfenidone says to take it with food. If you take Babassu on an empty stomach out of habit, keep them separate — and take Pirfenidone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Pirfenidone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Take with food.

From the Dosage and Administration section of the FDA label we read for Pirfenidone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Pirfenidone

This page covers Babassu only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pirfenidone page lists 115 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Adrafinil (moderate), African Wild Potato (moderate), Alfalfa (moderate) and Angelica Archangelica (moderate).

By severity: 1 major · 80 moderate · 34 minor.

From our pharmacist’s overview on the Pirfenidone page

“Pirfenidone (Esbriet) slows the lung scarring of idiopathic pulmonary fibrosis, and when a drug is doing that kind of work, this is not a list to skim. Most of the 115 ingredients on file touch CYP1A2, the liver enzyme that clears pirfenidone, so they can push its blood level up (more nausea and liver strain) or drag it down and quietl…”

Reviewed by 2 · Jul 18, 2026

Open the Pirfenidone interaction page

How much people look this up

Where Babassu and Pirfenidone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Babassu
Steady interest

#733 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pirfenidone
Top half

#1,357 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Babassu reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Babassu and Pirfenidone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Babassu

What is Babassu?

Babassu
  • Skin and hair care
  • Inflammation
  • Wound healing
  • Digestive complaints
  • General wellness

Babassu comes from a Brazilian palm tree, and its oil and mesocarp flour are used in foods, cosmetics, and traditional remedies. Early lab and animal studies suggest possible anti-inflammatory and wound-healing effects, but there is very little human research to confirm any health benefit. If you want to try it, talk with your pharmacist or doctor first.

Attalea speciosa · Arecaceae · Kernel oil and the dried, powdered mesocarp (inner husk) · Oil, mesocarp flour/powder, capsules, topical creams and soaps

An interaction check asks whether these two react with each other — it does not ask whether Babassu is a good idea for someone in your situation. Here is what our Babassu record says about it on its own.

Babassu: dosing

There is no established standard dose for babassu as a supplement. Research has not identified a safe and effective amount for any health condition.If you use a babassu product, follow the directions on the label and do not exceed the recommended amount.

From our Babassu monograph — the full record covers uses, side effects and every documented interaction.

Read the full Babassu monograph & all interactions
Medication

About Pirfenidone

What Is Pirfenidone Used For?

Brand name: Esbriet

Pirfenidone — available as capsules and tablets under the brand name Esbriet, as well as generic pirfenidone products — is indicated for the treatment of idiopathic pulmonary fibrosis (IPF), a chronic, progressive disease in which scar tissue builds up in the lungs and makes breathing increasingly difficult.

Esbriet capsules and tablets, pirfenidone capsules, and pirfenidone tablets are each specifically approved for IPF. No other uses are supported by the available product labels.

See full Pirfenidone drug information
Keep checking

Other Drugs & Babassu

Browse every other medication we’ve checked against Babassu — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
127Moderate
0Minor
2,702No known interaction
127 Moderate 2,702 No interaction
Moderate

127 interactions

Showing 60 of 127 moderate interactions — see all 127 on the Babassu page.

No interaction 2,702 drugs checked — show the list

We also checked Babassu against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,702 medications checked with no known interaction — see the full Babassu list.

See the full Babassu interactions page
See every supplement checked against Pirfenidone, ranked by severity
Evidence & sources

Babassu References

The 2 references that drive our Babassu monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Azevedo, A. P., Farias, J. C., Costa, G. C., Ferreira, S. C., Aragao-Filho, W. C., Sousa, P. R., Pinheiro, M. T., Maciel, M. C., Silva, L. A., Lopes, A. S., Barroqueiro, E. S., Borges, M. O., Guerra, R. N., and Nascimento, F. R. Anti-thrombotic effect of
  2. Gaitan, E., Cooksey, R. C., Legan, J., Lindsay, R. H., Ingbar, S. H., and Medeiros-Neto, G. Antithyroid effects in vivo and in vitro of babassu and mandioca: a staple food in goiter areas of Brazil. Eur J Endocrinol 1994;131(2):138-144. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Babassu and Pirfenidone Together: Common Questions

Is it safe to take Babassu with Pirfenidone?
We do not list a known interaction between Babassu and Pirfenidone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Babassu and Pirfenidone at the same time of day?
At least one FDA label for a product containing Pirfenidone says to take it with food. If you take Babassu on an empty stomach out of habit, keep them separate and take Pirfenidone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Pirfenidone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Babassu and Pirfenidone combination checked?
Interactions in our licensed database are recorded against drug classes. Pirfenidone is filed under 4 classifications, and Babassu has documented interactions with 2 drug classes — none of Pirfenidone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Babassu interact with any other medications?
Yes. Babassu has 127 documented drug interactions in our database — Pirfenidone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pirfenidone interact with any supplements?
Yes. Pirfenidone has documented interactions with 115 supplements in our database — Babassu is not one of them. The Pirfenidone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Babassu monograph Uses, safety profile, and every drug interaction in one place Pirfenidone drug information The full plain-English guide to this medication Pirfenidone supplement interactions Every supplement checked against Pirfenidone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pirfenidone and Babassu?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.