Drug & supplement interaction

Banaba + Insulin Degludec, Liraglutide

Insulin Degludec, Liraglutide brand name: Xultophy 100/3.6.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Banaba has a moderate interaction with Insulin Degludec, Liraglutide. Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Banaba and Insulin Degludec, Liraglutide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Insulin Degludec, Liraglutide

Insulin Degludec, Liraglutide falls under ANTIDIABETES DRUGS — the group Banaba interacts with.

Theoretically, concomitant use of banaba and hypoglycemic drugs might have additive effects.
Human and animal research suggests that banaba can lower blood glucose levels.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Xultophy is a once-daily injection that pairs a long-acting insulin (degludec) with a GLP-1 medicine (liraglutide). Both work to bring your blood sugar down. Banaba leaf may gently nudge blood sugar lower too, so stacking the two could add up and push your numbers too low.

If that happens, you might feel shaky, sweaty, dizzy, hungry, or confused, the usual signs of low blood sugar (hypoglycemia). The research here is fairly limited and short-term, so this is more of a sensible caution than a sure thing. Please don't change your Xultophy dose on your own. If you're curious about banaba, check in with your pharmacist or doctor first, keep checking your sugars closely, and have fast-acting carbs handy just in case.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Judy WV, Hari SP, Stogsdill WW, et al. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol 2003;87:115-7. PubMed
  2. Kakuda T, Sakane I, Takihara T, et al. Hypoglycemic effect of extracts from Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice. Biosci Biotechnol Biochem 1996;60:204-8.
  3. Fukushima, M., Matsuyama, F., Ueda, N., Egawa, K., Takemoto, J., Kajimoto, Y., Yonaha, N., Miura, T., Kaneko, T., Nishi, Y., Mitsui, R., Fujita, Y., Yamada, Y., and Seino, Y. Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Res C PubMed
  4. Manaf A, Tjandrawinata RR, Malinda D. Insulin sensitizer in prediabetes: a clinical study with DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa. Drug Des Devel Ther. 2016;10:1279-89. PubMed
  5. Tjokroprawiro A, Murtiwi S, Tjandrawinata RR. DLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa, in type-2 diabetes mellitus patients inadequately controlled by metformin and other oral antidiabetic agents. J Comple

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Banaba Also Interacts With Other Medications

Banaba has 298 moderate known drug interactions in our database — the Insulin Degludec, Liraglutide one above is one of them. If you take anything else, check it against the full list below.

Moderate 298 No known interaction 2,532 (incl. Insulin Degludec, Liraglutide)
Taking anything else?

Check Another of Your Medications Against Banaba

Covers the 2,830 medications we’ve checked against Banaba. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Insulin Degludec, Liraglutide

This page covers Banaba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Degludec, Liraglutide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Degludec, Liraglutide page

“Every ingredient on this page acts on blood sugar one way or the other, which is why this list deserves genuine care from anyone using Xultophy (insulin degludec and liraglutide), a combination injection for type 2 diabetes. Most of the entries add to the pen's glucose-lowering effect and raise the odds of hypoglycemia, while a smaller…”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Degludec, Liraglutide interaction page

One more smart check

Taking Banaba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 573 real supplement products containing Banaba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Banaba. Your product may carry other ingredients that interact with Insulin Degludec, Liraglutide too, on top of Banaba — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Banaba and Insulin Degludec, Liraglutide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Banaba
Top 25%

#218 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Degludec, Liraglutide
Top 5%

#100 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Banaba

What is Banaba?

Banaba
  • Blood sugar support
  • Type 2 diabetes
  • Weight management
  • High blood pressure
  • Cholesterol support

Banaba is a leaf extract most often used to help support healthy blood sugar, and small early studies suggest its active compound corosolic acid may modestly lower glucose. The overall evidence is limited and short-term, so it should not replace prescribed diabetes care. Talk to your pharmacist or doctor before trying it, especially if you take blood sugar medicine.

Read the full Banaba monograph & all interactions
Keep checking

Other Drugs & Banaba

Browse every other medication we’ve checked against Banaba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
298Moderate
0Minor
2,531No known interaction
298 Moderate 2,531 No interaction
Moderate

298 interactions

Showing 60 of 298 moderate interactions — see all 298 on the Banaba page.

No interaction 2,531 drugs checked — show the list

We also checked Banaba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,531 medications checked with no known interaction — see the full Banaba list.

See the full Banaba interactions page
See every supplement checked against Insulin Degludec, Liraglutide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Banaba monograph › Uses, safety, and every drug interaction in one place Insulin Degludec, Liraglutide supplement interactions › Every supplement checked against Insulin Degludec, Liraglutide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Banaba and Insulin Degludec, Liraglutide Together: Common Questions

Can you take Banaba with Insulin Degludec, Liraglutide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Banaba and Insulin Degludec, Liraglutide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Degludec, Liraglutide and Banaba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.