Medication interaction hub

What Supplements Interact with Insulin Degludec, Liraglutide?

Insulin Degludec, Liraglutide brand name: Xultophy 100/3.6. Every interaction below applies to the brands too.

239 Interactions 1 Major 208 Moderate 30 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Insulin Degludec, Liraglutide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Insulin Degludec, Liraglutide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Every ingredient on this page acts on blood sugar one way or the other, which is why this list deserves genuine care from anyone using Xultophy (insulin degludec and liraglutide), a combination injection for type 2 diabetes. Most of the entries add to the pen's glucose-lowering effect and raise the odds of hypoglycemia, while a smaller set, niacin among them, pushes glucose up and blunts the treatment. Siberian cocklebur stands apart. It has caused severe hypoglycemia in people and should not be combined with this drug at all.

Beer belongs here too; alcohol impairs the liver's glucose output while its carbohydrates raise sugar. Checking glucose more often whenever a supplement is added catches trouble early. The lone major entry, the cocklebur, sits above 208 moderate and 30 minor interactions, 239 in all, nearly every one a blood-sugar effect stacked onto a pen already delivering two glucose-lowering medicines.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 208 Minor 30 No known interaction 1,213

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Insulin Degludec, Liraglutide: Top Interactions at a Glance

The most significant Insulin Degludec, Liraglutide supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 239 interacting ingredients — plus 1,213 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Insulin Degludec, Liraglutide + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Siberian Cocklebur + Insulin Degludec, Liraglutidei

Siberian cocklebur seedlings and seeds have caused severe hypoglycemia in humans.

Read the full interaction
The complete list

Every Supplement Checked Against Insulin Degludec, Liraglutide

All 1,452 ingredients in our database, ranked by severity — 239 with a Insulin Degludec, Liraglutide interaction on file and 1,213 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Insulin Degludec, Liraglutide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Blue Cohosh with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that blue cohosh might increase blood glucose levels.

Full Blue Cohosh + Insulin Degludec, Liraglutide answer

Can you take Coffee with Insulin Degludec, Liraglutide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.

Full Coffee + Insulin Degludec, Liraglutide answer

Can you take Gymnema with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.

Full Gymnema + Insulin Degludec, Liraglutide answer

Can you take Inositol Nicotinate with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, inositol nicotinate might increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Full Inositol Nicotinate + Insulin Degludec, Liraglutide answer

Can you take Ivy Gourd with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ivy gourd may lower blood glucose levels and might have additive effects when used with antidiabetes drugs.

Full Ivy Gourd + Insulin Degludec, Liraglutide answer

Can you take Niacin with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.

Full Niacin + Insulin Degludec, Liraglutide answer

Can you take Panax Ginseng with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with antidiabetes drugs might increase the risk of hypoglycemia.

Full Panax Ginseng + Insulin Degludec, Liraglutide answer

Can you take Papaya with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.

Full Papaya + Insulin Degludec, Liraglutide answer

Can you take Prickly Pear Cactus with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.

Full Prickly Pear Cactus + Insulin Degludec, Liraglutide answer

Can you take Ribose with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ribose + Insulin Degludec, Liraglutide answer

Can you take Salacia with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Salacia + Insulin Degludec, Liraglutide answer

Can you take Sida Cordifolia with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Sida cordifolia might reduce the effectiveness of antidiabetes drugs.

Full Sida Cordifolia + Insulin Degludec, Liraglutide answer

Can you take Tree Turmeric with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tree turmeric, taken alone or in combination with milk thistle, might increase the risk of hypoglycemia in patients taking an...

Full Tree Turmeric + Insulin Degludec, Liraglutide answer

Can you take Vanadium with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Vanadium + Insulin Degludec, Liraglutide answer

Can you take Wine with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Wine + Insulin Degludec, Liraglutide answer

Can you take Acai with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Full Acai + Insulin Degludec, Liraglutide answer

Can you take African Wild Potato with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that African wild potato lowers blood glucose levels.

Full African Wild Potato + Insulin Degludec, Liraglutide answer

Can you take Agaricus Mushroom with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agaricus Mushroom + Insulin Degludec, Liraglutide answer

Can you take Agmatine with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Agmatine + Insulin Degludec, Liraglutide answer

Can you take Agrimony with Insulin Degludec, Liraglutide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agrimony with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agrimony + Insulin Degludec, Liraglutide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Insulin Degludec, Liraglutide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Insulin Degludec, Liraglutide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Insulin Degludec, Liraglutide sits in 1 interaction category. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Insulin Degludec, Liraglutide through this category.

Related: does Insulin Degludec, Liraglutide deplete any nutrients?

Insulin Degludec, Liraglutide has 1 reported nutrient association in the research literature — see the Insulin Degludec, Liraglutide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Insulin Degludec, Liraglutide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Insulin Degludec, Liraglutide.

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Pharmacist Counseling Corner

Insulin Degludec, Liraglutide & Supplements: Common Questions

What supplements interact with Insulin Degludec, Liraglutide?
More than you might expect — 239 in total, though they are far from equal: 1 are rated major, 208 moderate, and 30 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, American Ginseng, Astragalus.
Which Insulin Degludec, Liraglutide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Insulin Degludec, Liraglutide?
Usually yes — most people on Insulin Degludec, Liraglutide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Xultophy 100/3.6 have the same supplement interactions as Insulin Degludec, Liraglutide?
Yes — Xultophy 100/3.6 all contain Insulin Degludec, Liraglutide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Insulin Degludec, Liraglutide deplete any vitamins or nutrients?
It might — Insulin Degludec, Liraglutide has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Insulin Degludec, Liraglutide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Insulin Degludec, Liraglutide and my other medications?
This page covers Insulin Degludec, Liraglutide against supplements and herbal ingredients. Checking Insulin Degludec, Liraglutide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.