Drug & supplement interaction

Puravive + Insulin Degludec, Liraglutide

Insulin Degludec, Liraglutide brand name: Xultophy 100/3.6.

Minor Interaction
Medically reviewed by · Updated February 2024
The bottom line Minor

Puravive has a minor interaction with Insulin Degludec, Liraglutide. Puravive contains Panax ginseng. Clinical studies indicate that Panax ginseng may lower blood sugar levels.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Puravive and Insulin Degludec, Liraglutide

Here is the interaction we found between these two, with the evidence behind it.

Minor

Antidiabetes Drugs

Why this applies to Insulin Degludec, Liraglutide

Insulin Degludec, Liraglutide falls under Antidiabetes Drugs — the group Puravive interacts with.

Puravive contains Panax ginseng. Clinical studies indicate that Panax ginseng may lower blood sugar levels. One study (https://pubmed.ncbi.nlm.nih.gov/25015735/) found that supplementation with Panax ginseng led to a significant decrease in post-meal glucose levels and an increase in post-meal insulin levels compared to a placebo. If you are taking medications that lower blood sugar, it's important to monitor your blood glucose levels closely when using Panax ginseng.
Severity Minor Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep an eye on with Xultophy. This pen combines two blood-sugar-lowering medicines: insulin degludec (a long-acting insulin) and liraglutide (a GLP-1 drug). Puravive contains Panax ginseng, and some studies suggest ginseng can nudge blood sugar down a little on its own. Stack that on top of an insulin combo and the two effects can add up, so your sugar could drop lower than expected.

This is rated a minor interaction and it's not likely to be dramatic, but low blood sugar with insulin is worth respecting. Watch for shakiness, sweating, dizziness, or feeling foggy. If you'd like to try Puravive, check your glucose more often at first and chat with your pharmacist or doctor before starting.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Puravive Also Interacts With Other Medications

Puravive has 357 moderate, 880 minor known drug interactions in our database — the Insulin Degludec, Liraglutide one above is one of them. If you take anything else, check it against the full list below.

Moderate 357 Minor 880 No known interaction 1,593 (incl. Insulin Degludec, Liraglutide)
Taking anything else?

Check Another of Your Medications Against Puravive

Covers the 2,830 medications we’ve checked against Puravive. Pick one to open its full report.

From our Q&A

Questions About Puravive or Insulin Degludec, Liraglutide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Puravive or Insulin Degludec, Liraglutide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Insulin Degludec, Liraglutide

This page covers Puravive only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin Degludec, Liraglutide page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Insulin Degludec, Liraglutide page

“Every ingredient on this page acts on blood sugar one way or the other, which is why this list deserves genuine care from anyone using Xultophy (insulin degludec and liraglutide), a combination injection for type 2 diabetes. Most of the entries add to the pen's glucose-lowering effect and raise the odds of hypoglycemia, while a smaller…”

Reviewed by 2 · Jul 18, 2026

Open the Insulin Degludec, Liraglutide interaction page

How much people look this up

Where Puravive and Insulin Degludec, Liraglutide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Puravive
Top half

#621 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Insulin Degludec, Liraglutide
Top 5%

#48 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Puravive

What is Puravive?

Puravive
  • Weight management
  • Metabolism support
  • Energy levels
  • General wellness
  • Stress and brain health

Puravive is a branded, multi-ingredient capsule marketed mainly for weight loss by claiming to boost brown fat activity, but there is no published, independent clinical research showing the product itself works for this purpose. Some individual ingredients have been studied in laboratory or small human studies, but those results do not prove the finished blend is safe or effective. Talk to a pharmacist or doctor before trying it, especially if you have health conditions or take medications.

Read the full Puravive monograph & all interactions
Keep checking

Other Drugs & Puravive

Browse every other medication we’ve checked against Puravive — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
357Moderate
880Minor
1,592No known interaction
357 Moderate 880 Minor 1,592 No interaction
Moderate

357 interactions

Showing 60 of 357 moderate interactions — see all 357 on the Puravive page.

Minor

880 interactions

Showing 60 of 880 minor interactions — see all 880 on the Puravive page.

No interaction 1,592 drugs checked — show the list

We also checked Puravive against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,592 medications checked with no known interaction — see the full Puravive list.

See the full Puravive interactions page
See every supplement checked against Insulin Degludec, Liraglutide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Puravive monograph › Uses, safety, and every drug interaction in one place Insulin Degludec, Liraglutide supplement interactions › Every supplement checked against Insulin Degludec, Liraglutide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Puravive and Insulin Degludec, Liraglutide Together: Common Questions

Can you take Puravive with Insulin Degludec, Liraglutide?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Puravive and Insulin Degludec, Liraglutide interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Insulin Degludec, Liraglutide and Puravive?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.