Drug & supplement interaction

Beta-methylphenethylamine (bmpea) + Chlorpheniramine, Methscopolamine, Phenylephrine

Chlorpheniramine, Methscopolamine, Phenylephrine brand names: DA II, Extendryl JR, Dallergy, Extendryl SR, Extendryl Chews, and others.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Chlorpheniramine, Methscopolamine, Phenylephrine falls into 2 drug categories that Beta-methylphenethylamine (bmpea) can interact with; the most serious is rated moderate. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Beta-methylphenethylamine (bmpea) and Chlorpheniramine, Methscopolamine, Phenylephrine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Beta-methylphenethylamine (bmpea) interacts with whole categories of medication. Chlorpheniramine, Methscopolamine, Phenylephrine falls into 2 of those categories, so it can interact with Beta-methylphenethylamine (bmpea) in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

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Why this applies to Chlorpheniramine, Methscopolamine, Phenylephrine

Chlorpheniramine, Methscopolamine, Phenylephrine falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Beta-methylphenethylamine (bmpea) interacts with.

Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that BMPEA inhibits CYP3A4 by up to 37%.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination product mixes an antihistamine (chlorpheniramine), a drying agent (methscopolamine), and a decongestant (phenylephrine). Lab tests suggest BMPEA may block a liver enzyme called CYP3A4 by a little over a third. In theory, slowing that enzyme could let some of these ingredients build up in your body, which might make the usual side effects stronger: more drowsiness, dry mouth, blurred vision, constipation, trouble urinating, and a faster or pounding heartbeat.

Here's the bigger concern, though. BMPEA itself is a stimulant similar to amphetamine, and phenylephrine already raises blood pressure. Stacking two stimulant-type effects could push your heart rate and blood pressure higher. The enzyme link is only theoretical (based on lab data, not people), but BMPEA is unapproved and best avoided. Please run this by your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
Moderate

STIMULANT DRUGS

2 of 2

Chlorpheniramine, Methscopolamine, Phenylephrine also falls under STIMULANT DRUGS.

Theoretically, taking BMPEA with other stimulant drugs might increase the risk of adverse cardiovascular effects.
BMPEA is thought to have stimulant effects, including cardiovascular effects such as hypertension, tachycardia, and cardiac arrest.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the piece that matters with this combo product: it contains phenylephrine, which is a decongestant that already nudges up your blood pressure and can tighten blood vessels. BMPEA is a stimulant in the amphetamine family, so it can do the same kind of thing, raise heart rate and blood pressure. Stacking two stimulant-type ingredients can add up.

If you took them together, the realistic worry is feeling jittery, a racing or pounding heartbeat, higher blood pressure, headache, or trouble sleeping. To be fair, this concern is theoretical, based on how these compounds behave rather than solid human studies. BMPEA itself isn't a vetted supplement ingredient, so I'd steer clear of it. Please check with your pharmacist or doctor before mixing them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015 Apr 7. PubMed
  2. Brown DH, Hansson R, Oosthuizen F, et al. ß-Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation. Drug Test Anal 2016;8:344-50.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Beta-methylphenethylamine (bmpea) Also Interacts With Other Medications

Beta-methylphenethylamine (bmpea) has 812 moderate known drug interactions in our database — the Chlorpheniramine, Methscopolamine, Phenylephrine one above is among them. If you take anything else, check it against the full list below.

Moderate 812 No known interaction 2,018 (incl. Chlorpheniramine, Methscopolamine, Phenylephrine)
Taking anything else?

Check Another of Your Medications Against Beta-methylphenethylamine (bmpea)

Covers the 2,830 medications we’ve checked against Beta-methylphenethylamine (bmpea). Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Chlorpheniramine, Methscopolamine, Phenylephrine

This page covers Beta-methylphenethylamine (bmpea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorpheniramine, Methscopolamine, Phenylephrine page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Henbane (major) and Lithium (major).

By severity: 10 major · 175 moderate · 45 minor.

From our pharmacist’s overview on the Chlorpheniramine, Methscopolamine, Phenylephrine page

“This allergy and congestion combination, Chlorpheniramine, Methscopolamine, and Phenylephrine (Dallergy, Extendryl), has 230 supplement and herbal ingredients on its interaction list, and 10 of them carry major ratings, so this is a list to check carefully rather than skim. The largest group works through the liver enzyme that breaks t…”

Reviewed by 2 · Jul 18, 2026

Open the Chlorpheniramine, Methscopolamine, Phenylephrine interaction page

How much people look this up

Where Beta-methylphenethylamine (bmpea) and Chlorpheniramine, Methscopolamine, Phenylephrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beta-methylphenethylamine (bmpea)
Steady interest

#821 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorpheniramine, Methscopolamine, Phenylephrine
Top half

#1,068 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Beta-methylphenethylamine (bmpea)

What is Beta-methylphenethylamine (bmpea)?

  • Weight loss
  • Pre-workout energy
  • Athletic performance
  • Appetite suppression
  • Mental focus

Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and sports supplements, often without being clearly listed on the label. It is not an approved or well-studied dietary ingredient, and regulators have warned that it may carry real cardiovascular risks. Because of safety concerns and the lack of human research, it is best avoided.

Read the full Beta-methylphenethylamine (bmpea) monograph & all interactions
Keep checking

Other Drugs & Beta-methylphenethylamine (bmpea)

Browse every other medication we’ve checked against Beta-methylphenethylamine (bmpea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
812Moderate
0Minor
2,017No known interaction
812 Moderate 2,017 No interaction
Moderate

812 interactions

Showing 60 of 812 moderate interactions — see all 812 on the Beta-methylphenethylamine (bmpea) page.

No interaction 2,017 drugs checked — show the list

We also checked Beta-methylphenethylamine (bmpea) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,017 medications checked with no known interaction — see the full Beta-methylphenethylamine (bmpea) list.

See the full Beta-methylphenethylamine (bmpea) interactions page
See every supplement checked against Chlorpheniramine, Methscopolamine, Phenylephrine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Beta-methylphenethylamine (bmpea) monograph › Uses, safety, and every drug interaction in one place Chlorpheniramine, Methscopolamine, Phenylephrine supplement interactions › Every supplement checked against Chlorpheniramine, Methscopolamine, Phenylephrine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Beta-methylphenethylamine (bmpea) and Chlorpheniramine, Methscopolamine, Phenylephrine Together: Common Questions

Can you take Beta-methylphenethylamine (bmpea) with Chlorpheniramine, Methscopolamine, Phenylephrine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Beta-methylphenethylamine (bmpea) and Chlorpheniramine, Methscopolamine, Phenylephrine?
Chlorpheniramine, Methscopolamine, Phenylephrine belongs to more than one drug category, and Beta-methylphenethylamine (bmpea) interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Beta-methylphenethylamine (bmpea) and Chlorpheniramine, Methscopolamine, Phenylephrine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.