Beta-methylphenethylamine (bmpea) + Dextromethorphan, Guaifenesin, Pseudoephedrine
Dextromethorphan, Guaifenesin, Pseudoephedrine brand names: Pseudovent DM, Profen Forte DM, Profen II DM, Med Rx DM, Protuss DM, and others.
Dextromethorphan, Guaifenesin, Pseudoephedrine falls into 3 drug categories that Beta-methylphenethylamine (bmpea) can interact with; the most serious is rated moderate. Theoretically, BMPEA might increase the levels and clinical effects of CYP2D6 substrates.
Read the full interaction reportBeta-methylphenethylamine (bmpea) and Dextromethorphan, Guaifenesin, Pseudoephedrine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Beta-methylphenethylamine (bmpea) interacts with whole categories of medication. Dextromethorphan, Guaifenesin, Pseudoephedrine falls into 3 of those categories, so it can interact with Beta-methylphenethylamine (bmpea) in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 3Why this applies to Dextromethorphan, Guaifenesin, Pseudoephedrine
Dextromethorphan, Guaifenesin, Pseudoephedrine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Beta-methylphenethylamine (bmpea) interacts with.
In vitro research shows that BMPEA strongly inhibits CYP2D6.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the concern with this combo product. Your body uses an enzyme called CYP2D6 to clear out the dextromethorphan (the cough suppressant) part. In lab testing, BMPEA appears to strongly block that enzyme. If that happens in real life, dextromethorphan could build up more than expected and lead to things like drowsiness, dizziness, confusion, or in rarer cases agitation or a racing feeling.
On top of that, BMPEA acts like a stimulant, and so does the pseudoephedrine in this product. Stacking two stimulants can push your heart rate and blood pressure higher. To be honest, this interaction is theoretical and based on lab data, not human studies, but BMPEA itself is an unapproved, risky ingredient I'd steer clear of. Please run it by your pharmacist or doctor first.
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
2 of 3Dextromethorphan, Guaifenesin, Pseudoephedrine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro research shows that BMPEA inhibits CYP3A4 by up to 37%.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the bigger picture with this combo. BMPEA is a synthetic stimulant that's chemically a cousin of amphetamine, and your cough-and-cold product already contains pseudoephedrine, which is also a stimulant. So even before we talk about enzymes, stacking two stimulants together can really push up your heart rate and blood pressure, leaving you jittery, anxious, or unable to sleep.
On top of that, lab studies suggest BMPEA may mildly slow down the CYP3A4 enzyme that helps clear part of this medicine, which could let the dextromethorphan portion build up a bit (think more drowsiness or dizziness). This part is theoretical and only from test-tube data, so it's not a sure thing. Still, given the stimulant overlap, I'd skip BMPEA and check with your pharmacist.
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
STIMULANT DRUGS
3 of 3Dextromethorphan, Guaifenesin, Pseudoephedrine also falls under STIMULANT DRUGS.
BMPEA is thought to have stimulant effects, including cardiovascular effects such as hypertension, tachycardia, and cardiac arrest.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to keep in mind with this combo product. One of its three ingredients, pseudoephedrine, is itself a stimulant (it's a decongestant that can bump up your heart rate and blood pressure). BMPEA is a hidden amphetamine-like stimulant found in some weight-loss and workout supplements. So you'd essentially be stacking two stimulants on top of each other.
On paper, that combination could push your heart rate and blood pressure higher than either alone, possibly causing a racing or pounding heartbeat, jitteriness, headache, or trouble sleeping. I'll be honest, this concern is theoretical and based on how these compounds behave, not on solid human studies. Still, since BMPEA isn't well-studied or clearly labeled, I'd skip it. Please check with your pharmacist or doctor before mixing the two.
- Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015 Apr 7. PubMed
- Brown DH, Hansson R, Oosthuizen F, et al. ß-Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation. Drug Test Anal 2016;8:344-50.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Beta-methylphenethylamine (bmpea) Also Interacts With Other Medications
Beta-methylphenethylamine (bmpea) has 814 moderate known drug interactions in our database — the Dextromethorphan, Guaifenesin, Pseudoephedrine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Beta-methylphenethylamine (bmpea)
We haven’t checked that one against Beta-methylphenethylamine (bmpea) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Beta-methylphenethylamine (bmpea). Pick one to open its full report.
See Every Supplement That Interacts With Dextromethorphan, Guaifenesin, Pseudoephedrine
This page covers Beta-methylphenethylamine (bmpea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextromethorphan, Guaifenesin, Pseudoephedrine page lists 198 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Lithium (major) and Peyote (major).
By severity: 8 major · 149 moderate · 41 minor.
Open the Dextromethorphan, Guaifenesin, Pseudoephedrine interaction page
Where Beta-methylphenethylamine (bmpea) and Dextromethorphan, Guaifenesin, Pseudoephedrine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#873 of 1,452 supplements looked up here in the last 7 days
#590 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Beta-methylphenethylamine (bmpea)
What is Beta-methylphenethylamine (bmpea)?
- Weight loss
- Pre-workout energy
- Athletic performance
- Appetite suppression
- Mental focus
Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and sports supplements, often without being clearly listed on the label. It is not an approved or well-studied dietary ingredient, and regulators have warned that it may carry real cardiovascular risks. Because of safety concerns and the lack of human research, it is best avoided.
Other Drugs & Beta-methylphenethylamine (bmpea)
Browse every other medication we’ve checked against Beta-methylphenethylamine (bmpea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
814 interactions
- Diltiazem ›
- Nifedipine ›
- Phentermine ›
- Hydrocortisone ›
- Methylphenidate ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Phenylpropanolamine ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Nicotine ›
- Oxybutynin ›
- Oxycodone ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Miconazole ›
- Morphine Sulfate ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Diethylpropion ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Nortriptyline ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
Showing 60 of 814 moderate interactions — see all 814 on the Beta-methylphenethylamine (bmpea) page.
No interaction 2,015 drugs checked — show the list
We also checked Beta-methylphenethylamine (bmpea) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Rosuvastatin ›
- Acetaminophen ›
- Aspirin ›
- Levothyroxine, Liothyronine ›
- Ibuprofen ›
- Tirzepatide ›
- Isotretinoin ›
- Metformin ›
- Docusate ›
- Semaglutide ›
- Sumatriptan ›
- Amoxicillin ›
- Lisinopril ›
- Valacyclovir ›
- Hydroxyurea ›
- Bupropion ›
- Methotrexate ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Gabapentin ›
- Naproxen ›
- Lamotrigine ›
- Acyclovir ›
- Methylene Blue ›
- Bendamustine ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Acetylsalicylic Acid ›
- Acetaminophen, Aspirin ›
- Insulin Degludec, Liraglutide ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Aspirin, Butalbital ›
- Atenolol, Chlorthalidone ›
- Enalapril Maleate ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Ezetimibe ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Aspirin, Ethoheptazine, Meprobamate ›
- Cephalexin ›
- Rosiglitazone Maleate ›
- Sacubitril, Valsartan ›
- Canagliflozin, Metformin ›
- Insulin Aspart, Insulin Degludec ›
- Candesartan Cilexetil, Hydrochlorothiazide ›
- Levetiracetam ›
- Sulfamethoxazole, Trimethoprim ›
- Daunorubicin, Cytarabine ›
- Carbidopa, Levodopa ›
- Levodopa ›
- Saxagliptin, Metformin Xr ›
- Atenolol ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Sodium Bicarbonate (otc Drug) ›
- Atropine Methyl Nitrate, Digestive Enzymes ›
Showing the 60 most looked-up of 2,015 medications checked with no known interaction — see the full Beta-methylphenethylamine (bmpea) list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Beta-methylphenethylamine (bmpea) and Dextromethorphan, Guaifenesin, Pseudoephedrine Together: Common Questions
Can you take Beta-methylphenethylamine (bmpea) with Dextromethorphan, Guaifenesin, Pseudoephedrine?
Why are there 3 interactions listed for Beta-methylphenethylamine (bmpea) and Dextromethorphan, Guaifenesin, Pseudoephedrine?
How serious is the Beta-methylphenethylamine (bmpea) and Dextromethorphan, Guaifenesin, Pseudoephedrine interaction?
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