Beta-methylphenethylamine (bmpea) + Mefloquine
Mefloquine brand name: Lariam.
We found no known interaction between Beta-methylphenethylamine (bmpea) and Mefloquine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Mefloquine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Beta-methylphenethylamine (bmpea) and Mefloquine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Mefloquine and Beta-methylphenethylamine (bmpea) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Beta-methylphenethylamine (bmpea) safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Mefloquine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Mefloquine is filed under 2 classifications — seizure threshold lowering drugs, oral drugs. Beta-methylphenethylamine (bmpea) has documented interactions with 3 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate), cytochrome p450 3a4 (cyp3a4) substrates (moderate) and stimulant drugs (moderate) — and none of Mefloquine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Beta-methylphenethylamine (bmpea) Does Interact With Other Medications
Beta-methylphenethylamine (bmpea) has 813 moderate known drug interactions in our database — Mefloquine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Beta-methylphenethylamine (bmpea)
We haven’t checked that one against Beta-methylphenethylamine (bmpea) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Beta-methylphenethylamine (bmpea). Pick one to open its full report.
Beta-methylphenethylamine (bmpea) in Pregnancy & Breastfeeding
When used orally. BMPEA is an amphetamine-like compound that has been shown to have stimulant properties and is associated with severe cardiovascular adverse effects.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Mefloquine Products Have a Food Rule — Beta-methylphenethylamine (bmpea) Should Not Break It
At least one FDA label for a product containing Mefloquine says to take it on an empty stomach. Most supplements — Beta-methylphenethylamine (bmpea) included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Mefloquine on its own and move Beta-methylphenethylamine (bmpea) to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Mefloquine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
The drug should not be taken on an empty stomach and should be administered with at least 8 oz (240 mL) of water.
From the Dosage and Administration section of the FDA label we read for Mefloquine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Mefloquine
This page covers Beta-methylphenethylamine (bmpea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mefloquine page lists 23 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).
By severity: 1 major · 13 moderate · 9 minor.
From our pharmacist’s overview on the Mefloquine page
“Mefloquine (Lariam) prevents and treats malaria and carries its own well-known warnings about seizures and psychiatric effects, so I take this interaction list more seriously than most. Six of the 23 supplements on file, including ginkgo and melatonin, may lower the seizure threshold, a poor match for a drug with mefloquine's neurologi…”
Reviewed by 2 · Jul 18, 2026
Where Beta-methylphenethylamine (bmpea) and Mefloquine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#761 of 1,452 supplements looked up here in the last 7 days
#1,525 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beta-methylphenethylamine (bmpea) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Beta-methylphenethylamine (bmpea) and Mefloquine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Beta-methylphenethylamine (bmpea)
What is Beta-methylphenethylamine (bmpea)?
- Weight loss
- Pre-workout energy
- Athletic performance
- Appetite suppression
- Mental focus
Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and sports supplements, often without being clearly listed on the label. It is not an approved or well-studied dietary ingredient, and regulators have warned that it may carry real cardiovascular risks. Because of safety concerns and the lack of human research, it is best avoided.
Synthetic chemical; also reported as a constituent of some Acacia species · Capsules, tablets, and powders sold as pre-workout, weight-loss, or 'energy' supplements
An interaction check asks whether these two react with each other — it does not ask whether Beta-methylphenethylamine (bmpea) is a good idea for someone in your situation. Here is what our Beta-methylphenethylamine (bmpea) record says about it on its own.
Beta-methylphenethylamine (bmpea): dosing
There is no established or recommended dose for BMPEA, and no safe dose has been determined through research. It is not an approved ingredient, so any amount in a supplement is unregulated and may not match what the label says.We do not recommend taking BMPEA.
From our Beta-methylphenethylamine (bmpea) monograph — the full record covers uses, side effects and every documented interaction.
About Mefloquine
What Is Mefloquine Used For?
Brand name: Lariam
Mefloquine Hydrochloride tablets are used to treat mild to moderate acute malaria caused by Plasmodium falciparum (including strains resistant to chloroquine) and Plasmodium vivax. They are also used to prevent malaria infections, including chloroquine-resistant strains of P. falciparum, in people traveling to malaria-endemic areas.
Important note: mefloquine does not eliminate the liver stage of P. vivax, so patients treated for P. vivax malaria usually need an additional medication (such as primaquine) afterward to prevent relapse.
Other Drugs & Beta-methylphenethylamine (bmpea)
Browse every other medication we’ve checked against Beta-methylphenethylamine (bmpea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
813 interactions
- Diltiazem ›
- Nifedipine ›
- Phentermine ›
- Hydrocortisone ›
- Methylphenidate ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Phenylpropanolamine ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Nicotine ›
- Oxybutynin ›
- Oxycodone ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Miconazole ›
- Morphine Sulfate ›
- Phenylephrine ›
- Pseudoephedrine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Diethylpropion ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Nortriptyline ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
Showing 60 of 813 moderate interactions — see all 813 on the Beta-methylphenethylamine (bmpea) page.
No interaction 2,016 drugs checked — show the list
We also checked Beta-methylphenethylamine (bmpea) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Ibuprofen ›
- Tirzepatide ›
- Valacyclovir ›
- Sumatriptan ›
- Hydroxyurea ›
- Semaglutide ›
- Metformin ›
- Methotrexate ›
- Isotretinoin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Bendamustine ›
- Doxycycline ›
- Azithromycin ›
- Pregabalin ›
- Acyclovir ›
- Gabapentin ›
- Lamotrigine ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Acetaminophen, Aspirin ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Cephalexin ›
- Ezetimibe ›
- Acetylsalicylic Acid ›
- Thyroid Hormone ›
- Carbidopa, Levodopa ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Spironolactone ›
- Phentermine, Topiramate ›
- Levodopa ›
- Levothyroxine Sodium ›
- Mitomycin ›
- Valsartan ›
- Atenolol ›
- Pizotifen ›
- Acetaminophen, Ibuprofen ›
- Canagliflozin, Metformin ›
- Daptomycin ›
- Hydroxychloroquine ›
- Acarbose ›
- Cefaclor ›
- Insulin Degludec, Liraglutide ›
- Diclofenac Sodium ›
- Magnesium Hydroxide (otc Drug) ›
Showing the 60 most looked-up of 2,016 medications checked with no known interaction — see the full Beta-methylphenethylamine (bmpea) list.
Beta-methylphenethylamine (bmpea) References
The 5 references that drive our Beta-methylphenethylamine (bmpea) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. PubMed
- Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015 Apr 7. PubMed
- Cohen PA, Zeijlon R, Nardin R, Keizers PH, Venhuis B. Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing ß-Methylphenyl-ethylamine (BMPEA): A Case Report. Ann Intern Med. 2015 Jun 16;162(12):879-80. doi: 10.7326/L1 DOI
- Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
- Brown DH, Hansson R, Oosthuizen F, et al. ß-Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation. Drug Test Anal 2016;8:344-50.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Beta-methylphenethylamine (bmpea) and Mefloquine Together: Common Questions
Is it safe to take Beta-methylphenethylamine (bmpea) with Mefloquine?
Do Beta-methylphenethylamine (bmpea) and Mefloquine have any of the same side effects?
Should I take Beta-methylphenethylamine (bmpea) and Mefloquine at the same time of day?
How was the Beta-methylphenethylamine (bmpea) and Mefloquine combination checked?
Does Beta-methylphenethylamine (bmpea) interact with any other medications?
Does Mefloquine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.