Drug & supplement interaction

Beta-methylphenethylamine (bmpea) + Memantine

Memantine brand name: Ebixa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Beta-methylphenethylamine (bmpea) and Memantine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Beta-methylphenethylamine (bmpea) and Memantine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Memantine and Beta-methylphenethylamine (bmpea) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Beta-methylphenethylamine (bmpea) safety at a glance

Beta-methylpheneth... overall Avoid BMPEA is an unapproved synthetic stimulant linked to safety concerns and is best avoided.
Pregnancy Possibly Unsafe When used orally. BMPEA is an amphetamine-like compound that has been shown to have stimulant properties and is associated with severe cardiovascular adverse ef... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. BMPEA is an amphetamine-like compound that has been shown to have stimulant properties and is associated with severe cardiovascular adverse ef... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Memantine and Beta-methylphenethylamine (bmpea)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Memantine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Memantine is filed under 2 classifications — nmda antagonists, oral drugs. Beta-methylphenethylamine (bmpea) has documented interactions with 3 drug classes — the most serious being cytochrome p450 2d6 (cyp2d6) substrates (moderate), cytochrome p450 3a4 (cyp3a4) substrates (moderate) and stimulant drugs (moderate) — and none of Memantine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Beta-methylphenethylamine (bmpea) Does Interact With Other Medications

Beta-methylphenethylamine (bmpea) has 813 moderate known drug interactions in our database — Memantine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 813 No known interaction 2,017 (incl. Memantine)
Taking anything else?

Check Another of Your Medications Against Beta-methylphenethylamine (bmpea)

Covers the 2,830 medications we’ve checked against Beta-methylphenethylamine (bmpea). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Beta-methylphenethylamine (bmpea) and Memantine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Beta-methylphenethylamine (bmpea)

    “BMPEA is an amphetamine derivative which can cause serious stimulant adverse effects.

    Most Common Adverse Effects:

    Hypertension and tachycardia.

    Serious Adverse Effects (Rare):

    Cardiac arrest, stroke.”

    Beta-methylphenethylamine (bmpea) · Natural Medicines adverse-effect record, reported in cardiac arrest.

    Memantine

    Listed in the ADVERSE REACTIONS section of the FDA label for Memantine. Read the label on DailyMed ›

Reported for Beta-methylphenethylamine (bmpea) but not commonly for Memantine: a stroke or mini-stroke and a fast or pounding heartbeat.

Effects for Memantine come from the ADVERSE REACTIONS section of its FDA label; effects for Beta-methylphenethylamine (bmpea) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Beta-methylphenethylamine (bmpea) in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. BMPEA is an amphetamine-like compound that has been shown to have stimulant properties and is associated with severe cardiovascular adverse effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Memantine Is Prescribed For, and What Beta-methylphenethylamine (bmpea) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Memantine is a prescription medicine with approved uses on its FDA label. Beta-methylphenethylamine (bmpea) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Memantine is prescribed for: Memantine treats moderate to severe dementia of the Alzheimer's type. It is available as tablets, extended-release capsules, and an oral solution — all approved for this same use. It does not cure Alzheimer's disease and is not shown to prevent or slow the underlying loss of brain cells. It is used to help manage symptoms of moderate to severe disease.

Beta-methylphenethylamine (bmpea) has been studied for:

  • Memory studied, not established Beta-methylphenethylamine (bmpea) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Beta-methylphenethylamine (bmpea) for memory

    Although there has been interest in using oral BMPEA to improve memory, there is insufficient reliable information about the clinical effects of BMPEA for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Memantine on your own; if you are taking Beta-methylphenethylamine (bmpea) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Memantine

This page covers Beta-methylphenethylamine (bmpea) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Memantine page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Threonine (major), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 2 major · 7 moderate · 9 minor.

Open the Memantine interaction page

How much people look this up

Where Beta-methylphenethylamine (bmpea) and Memantine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beta-methylphenethylamine (bmpea)
Steady interest

#1,384 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Memantine
Top 25%

#562 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beta-methylphenethylamine (bmpea) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Beta-methylphenethylamine (bmpea) and Memantine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Beta-methylphenethylamine (bmpea)

What is Beta-methylphenethylamine (bmpea)?

  • Weight loss
  • Pre-workout energy
  • Athletic performance
  • Appetite suppression
  • Mental focus

Beta-methylphenethylamine (BMPEA) is a synthetic stimulant chemically similar to amphetamine that has been found in some weight-loss and sports supplements, often without being clearly listed on the label. It is not an approved or well-studied dietary ingredient, and regulators have warned that it may carry real cardiovascular risks. Because of safety concerns and the lack of human research, it is best avoided.

Synthetic chemical; also reported as a constituent of some Acacia species · Capsules, tablets, and powders sold as pre-workout, weight-loss, or 'energy' supplements

An interaction check asks whether these two react with each other — it does not ask whether Beta-methylphenethylamine (bmpea) is a good idea for someone in your situation. Here is what our Beta-methylphenethylamine (bmpea) record says about it on its own.

Beta-methylphenethylamine (bmpea): dosing

There is no established or recommended dose for BMPEA, and no safe dose has been determined through research. It is not an approved ingredient, so any amount in a supplement is unregulated and may not match what the label says.We do not recommend taking BMPEA.

From our Beta-methylphenethylamine (bmpea) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Beta-methylphenethylamine (bmpea) monograph & all interactions
Medication

About Memantine

What Is Memantine Used For?

Brand name: Ebixa

Memantine treats moderate to severe dementia of the Alzheimer's type. It is available as tablets, extended-release capsules, and an oral solution — all approved for this same use.

It does not cure Alzheimer's disease and is not shown to prevent or slow the underlying loss of brain cells. It is used to help manage symptoms of moderate to severe disease.

See full Memantine drug information
Keep checking

Other Drugs & Beta-methylphenethylamine (bmpea)

Browse every other medication we’ve checked against Beta-methylphenethylamine (bmpea) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
813Moderate
0Minor
2,016No known interaction
813 Moderate 2,016 No interaction
Moderate

813 interactions

Showing 60 of 813 moderate interactions — see all 813 on the Beta-methylphenethylamine (bmpea) page.

No interaction 2,016 drugs checked — show the list

We also checked Beta-methylphenethylamine (bmpea) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,016 medications checked with no known interaction — see the full Beta-methylphenethylamine (bmpea) list.

See the full Beta-methylphenethylamine (bmpea) interactions page
See every supplement checked against Memantine, ranked by severity
Evidence & sources

Beta-methylphenethylamine (bmpea) References

The 5 references that drive our Beta-methylphenethylamine (bmpea) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. PubMed
  2. Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, ß-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. 2015 Apr 7. PubMed
  3. Cohen PA, Zeijlon R, Nardin R, Keizers PH, Venhuis B. Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing ß-Methylphenyl-ethylamine (BMPEA): A Case Report. Ann Intern Med. 2015 Jun 16;162(12):879-80. doi: 10.7326/L1 DOI
  4. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
  5. Brown DH, Hansson R, Oosthuizen F, et al. ß-Methylphenylethylamines: common fragmentation pathways with amphetamines in electrospray ionization collision-induced dissociation. Drug Test Anal 2016;8:344-50.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Beta-methylphenethylamine (bmpea) and Memantine Together: Common Questions

Is it safe to take Beta-methylphenethylamine (bmpea) with Memantine?
We do not list a known interaction between Beta-methylphenethylamine (bmpea) and Memantine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Beta-methylphenethylamine (bmpea) and Memantine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Beta-methylphenethylamine (bmpea) and Memantine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Beta-methylphenethylamine (bmpea) in each. That is a conversation for your prescriber, especially if Memantine is being adjusted to a target.
How was the Beta-methylphenethylamine (bmpea) and Memantine combination checked?
Interactions in our licensed database are recorded against drug classes. Memantine is filed under 2 classifications, and Beta-methylphenethylamine (bmpea) has documented interactions with 3 drug classes — none of Memantine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Beta-methylphenethylamine (bmpea) interact with any other medications?
Yes. Beta-methylphenethylamine (bmpea) has 813 documented drug interactions in our database — Memantine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Memantine interact with any supplements?
Yes. Memantine has documented interactions with 18 supplements in our database — Beta-methylphenethylamine (bmpea) is not one of them. The Memantine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Beta-methylphenethylamine (bmpea) monograph Uses, safety profile, and every drug interaction in one place Memantine drug information The full plain-English guide to this medication Memantine supplement interactions Every supplement checked against Memantine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Memantine and Beta-methylphenethylamine (bmpea)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.