Boswellia Serrata + Mirtazapine
Mirtazapine brand name: Remeron.
Mirtazapine falls into 3 drug categories that Boswellia Serrata can interact with; the most serious is rated moderate. Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full interaction reportBoswellia Serrata and Mirtazapine
These two interact in 3 distinct ways. Each one is explained separately below.
Why Are There 3 Interactions?
Boswellia Serrata interacts with whole categories of medication. Mirtazapine falls into 3 of those categories, so it can interact with Boswellia Serrata in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES
1 of 3Why this applies to Mirtazapine
Mirtazapine falls under CYTOCHROME P450 2D6 (CYP2D6) SUBSTRATES — the group Boswellia Serrata interacts with.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for mirtazapine (Remeron): your liver uses an enzyme called CYP2D6 as one of the ways to clear it out of your body. In test-tube studies, boswellic acids from boswellia appear to slow that enzyme down. If that happens in real life, a bit more mirtazapine could linger, which might nudge up its usual effects like drowsiness, grogginess, increased appetite, weight gain, or dizziness.
The important part: this is only a theoretical concern based on lab work, not on real patients, so I wouldn't lose sleep over it. Mirtazapine also uses several other enzyme pathways, so one slowed enzyme is rarely a big deal. Still, if you plan to add boswellia, mention it to your pharmacist or doctor first, especially if you notice extra sleepiness.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES
2 of 3Mirtazapine also falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist for these two together. Your body uses several liver enzymes to clear mirtazapine, and one of them is CYP1A2. In lab dish studies, boswellia appears to slow that enzyme down a bit. If that happened in real life, mirtazapine could clear a little more slowly and build up slightly. Mirtazapine is the active drug itself, not a prodrug, so higher levels would mean a stronger effect.
Practically, that might show up as more drowsiness, grogginess, increased appetite, or feeling foggy. The big caveat is that this is only a theoretical concern from test-tube research, not from people, so the real-world risk is probably small. Still, if you notice extra sleepiness after adding boswellia, mention it to your pharmacist or doctor before changing anything.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
3 of 3Mirtazapine also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the gist with mirtazapine (Remeron): your liver uses an enzyme called CYP3A4 to help break it down, and lab studies hint that boswellia might block that enzyme. If that happened in real life, mirtazapine could clear a little slower and build up, which might bump up its usual effects like drowsiness, dizziness, dry mouth, increased appetite, and weight gain. Mirtazapine is an active drug (not a prodrug), so blocking the enzyme tends to mean a bit more effect, not less.
The big caveat: this is purely theoretical, based on test-tube research, not real patients. For many people it won't cause a noticeable problem. Still, if you feel extra sleepy or off, mention it to your pharmacist or doctor before changing anything.
- Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Boswellia Serrata Also Interacts With Other Medications
Boswellia Serrata has 953 moderate known drug interactions in our database — the Mirtazapine one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Boswellia Serrata
We haven’t checked that one against Boswellia Serrata yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Boswellia Serrata. Pick one to open its full report.
Questions About Boswellia Serrata or Mirtazapine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Boswellia Serrata or Mirtazapine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does DIM (Diindolylmethane) Interact With Any Drugs? ›
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Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Mirtazapine
This page covers Boswellia Serrata only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mirtazapine page lists 212 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).
By severity: 4 major · 162 moderate · 46 minor.
From our pharmacist’s overview on the Mirtazapine page
“Depression and poor sleep tend to travel together, which is why people on mirtazapine (Remeron) so often eye herbal mood and sleep remedies, and that overlap is exactly where this list demands real care. Four of the 212 ingredients on file carry a major rating.”
Reviewed by 2 · Jul 18, 2026
Taking Boswellia Serrata as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,914 real supplement products containing Boswellia Serrata, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Boswellia Serrata. Your product may carry other ingredients that interact with Mirtazapine too, on top of Boswellia Serrata — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Boswellia Serrata and Mirtazapine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#94 of 1,452 supplements looked up here in the last 7 days
#420 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Boswellia Serrata
What is Boswellia Serrata?
- Osteoarthritis joint pain
- Rheumatoid arthritis
- Inflammation
- Asthma
- Inflammatory bowel conditions
Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidence is limited and more research is needed. It is generally well tolerated, but you should check with your pharmacist or doctor before using it, especially during pregnancy or breastfeeding.
About Mirtazapine
What Is Mirtazapine Used For?
Brand name: Remeron
Mirtazapine is used to treat major depressive disorder (MDD), commonly called clinical depression. The mirtazapine tablet and orally disintegrating tablet labels, including Remeron and RemeronSolTab, state use in adults.
In studies, it worked in six-week trials, and one trial showed the benefit lasted for up to 40 weeks in people who had already responded. Doctors should periodically re-check whether longer-term use is still helping.
Other Drugs & Boswellia Serrata
Browse every other medication we’ve checked against Boswellia Serrata — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
953 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Theophylline ›
- Nifedipine ›
- Ibuprofen ›
- Hydrocortisone ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Flurbiprofen ›
- Oxybutynin ›
- Oxycodone ›
- Phenytoin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Indomethacin ›
- Miconazole ›
- Morphine Sulfate ›
- Trimipramine ›
- Acetaminophen ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Lofepramine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Meloxicam ›
- Nortriptyline ›
- Propoxyphene ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
Showing 60 of 953 moderate interactions — see all 953 on the Boswellia Serrata page.
No interaction 1,876 drugs checked — show the list
We also checked Boswellia Serrata against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Rosuvastatin ›
- Aspirin ›
- Tirzepatide ›
- Isotretinoin ›
- Levothyroxine, Liothyronine ›
- Metformin ›
- Docusate ›
- Semaglutide ›
- Sumatriptan ›
- Lisinopril ›
- Valacyclovir ›
- Amoxicillin ›
- Hydroxyurea ›
- Bupropion ›
- Methotrexate ›
- Azithromycin ›
- Doxycycline ›
- Pregabalin ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Aluminum Hydroxide, Aspirin, Magnesium Hydroxide ›
- Acetylsalicylic Acid ›
- Insulin Degludec, Liraglutide ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Aminophylline, Amobarbital, Ephedrine ›
- Aspirin, Butalbital ›
- Atenolol, Chlorthalidone ›
- Enalapril Maleate ›
- Ezetimibe ›
- Cephalexin ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Ephedrine, Phenobarbital, Theophylline ›
- Aspirin, Ethoheptazine, Meprobamate ›
- Levetiracetam ›
- Insulin Aspart, Insulin Degludec ›
- Cyclopentolate ›
- Candesartan Cilexetil, Hydrochlorothiazide ›
- Canagliflozin, Metformin ›
- Levodopa ›
- Atenolol ›
- Daunorubicin, Cytarabine ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Carbidopa, Levodopa ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Saxagliptin, Metformin Xr ›
- Sodium Bicarbonate (otc Drug) ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Amobarbital, Ephedrine Sulfate ›
- Cytomegalovirus Immune Globulin ›
- Thyroid Hormone ›
- Alginic Acid, Aluminum Hydroxide ›
Showing the 60 most looked-up of 1,876 medications checked with no known interaction — see the full Boswellia Serrata list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Mirtazapine Is Linked to Lower Levels of One Nutrient
Natural Medicines records Mirtazapine as a medicine that can lower these. This is not an interaction with Boswellia Serrata — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Mirtazapine nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Boswellia Serrata and Mirtazapine Together: Common Questions
Can you take Boswellia Serrata with Mirtazapine?
Why are there 3 interactions listed for Boswellia Serrata and Mirtazapine?
How serious is the Boswellia Serrata and Mirtazapine interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Mirtazapine and Boswellia Serrata?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.