Boxwood - Evoxac (Cevimeline) Interaction
Herbal: Boxwood
Also Known As: Buxus sempervirens, Bois d'Artois, Bois Béni, Bois Ordinaire, Boj, Boje, Boxwood Extract, Buis, Buis Commun, Buis Toujours Vert, Bujo, Bush Tree, Buxaceae, Buxus, Dudgeon, European Box, Extrait de Buis, SPV 30
Drug: Cevimeline
Brand names:
Evoxac
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Cevimeline is classified as belonging to the following category: Cholinergic Drugs
Evidence from in vitro research suggests that boxwood extract can inhibit acetylcholinesterase activity. Theoretically, concurrent use of boxwood with other cholinergic drugs might have additive effects and increase the risk of cholinergic side effects.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Orhan, I., Sener, B., Choudhary, M. I., and Khalid, A. Acetylcholinesterase and butyrylcholinesterase inhibitory activity of some Turkish medicinal plants. J Ethnopharmacol 2004;91(1):57-60.
Boxwood Overview
Boxwood is a type of shrub that is commonly used in landscaping and gardening. It belongs to the Buxus genus, which includes about 70 species of evergreen plants. The leaves of boxwood have been used in traditional medicine to treat malaria, and to boost immunity. Boxwood has also been used to treat arthritis and diabetes. Boxwood supplements are generally processed extracts since the whole leaf of the plant is toxic to humans and animals.
Cevimeline Overview
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Cevimeline is used to treat the symptoms of dry mouth in patients with Sjogren's syndrome (a condition that affects the immune system and causes dryness of certain parts of the body such as the eyes and mouth). Cevimeline is in a class of medications called cholinergic agonists. It works by increasing the amount of saliva in the mouth.
Boxwood - More Interactions
Boxwood interacts with 216 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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