Drug & supplement interaction

Bridelia + Chloroprocaine

Chloroprocaine brand names: Nesacaine, Nescaine-MPF.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bridelia and Chloroprocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bridelia and Chloroprocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Chloroprocaine and Bridelia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bridelia safety at a glance

Bridelia overall Not established Human safety data are very limited, so use cautiously and under professional guidance.
Pregnancy Likely Unsafe When used orally. There is concern that Bridelia might have labor-inducing effects. In animals, Bridelia atroviridis leaf extract induces uterine contractions i... Read the full pregnancy detail
Breastfeeding Avoid There is no reliable safety data during breastfeeding, so avoid it.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Chloroprocaine and Bridelia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Chloroprocaine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Chloroprocaine is filed under a single classification — anesthesia. Bridelia has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and estrogens (moderate) — and none of Chloroprocaine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bridelia Does Interact With Other Medications

Bridelia has 330 moderate known drug interactions in our database — Chloroprocaine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 330 No known interaction 2,500 (incl. Chloroprocaine)
Taking anything else?

Check Another of Your Medications Against Bridelia

Covers the 2,830 medications we’ve checked against Bridelia. Pick one to open its full report.

What to actually watch for

What Chloroprocaine’s Own FDA Label Lists

This is not an interaction — none of it involves Bridelia. These are the most notable effects listed in the ADVERSE REACTIONS section of Chloroprocaine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • A slow heartbeat Worth acting on
  • Fainting Worth acting on
  • Seizures Worth acting on
  • Low mood Worth acting on
  • Hives Worth acting on
  • Ringing in the ears
  • Blurred vision
  • Sweating
  • Back pain
  • A fast or pounding heartbeat

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Chloroprocaine. Read the label on DailyMed › Bridelia’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Bridelia side to compare — that is a limit of the record, not a statement that Bridelia has no side effects.

Special populations

Bridelia in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. There is concern that Bridelia might have labor-inducing effects. In animals, Bridelia atroviridis leaf extract induces uterine contractions in a concentration-dependent manner.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Chloroprocaine

This page covers Bridelia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chloroprocaine page lists 5 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (major), Cannabis (moderate), Cowhage (moderate), Datura Wrightii (moderate) and Delta-9-tetrahydrocannabinol (thc) (moderate).

By severity: 1 major · 4 moderate.

From our pharmacist’s overview on the Chloroprocaine page

“Fever bark is the ingredient I would flag first for anyone scheduled to receive chloroprocaine (Nesacaine), a local anesthetic injected for epidurals and other numbing procedures. It holds the list's lone major rating because its constituent reserpine has been linked to unstable blood pressure and heart rhythm under anesthesia.”

Reviewed by 2 · Jul 18, 2026

Open the Chloroprocaine interaction page

How much people look this up

Where Bridelia and Chloroprocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bridelia
Steady interest

#1,313 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chloroprocaine
Steady interest

#1,678 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bridelia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bridelia and Chloroprocaine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bridelia

What is Bridelia?

  • Blood sugar support
  • Digestive complaints and diarrhea
  • Wound care and skin conditions
  • Antimicrobial use
  • Mouth and gum care (traditional chewing stick)

Bridelia is a group of tropical plants, with Bridelia ferruginea widely used in traditional African medicine for diabetes, infections, and digestive problems. Scientific evidence is mostly limited to laboratory and animal studies, so its benefits and safety in people are not well established. Talk to a pharmacist or doctor before using it, especially if you take other medicines or have a health condition.

Bridelia ferruginea · Phyllanthaceae · Bark, leaves, stem, and roots · Bark or leaf decoction (tea), powder, traditional extracts, capsules

An interaction check asks whether these two react with each other — it does not ask whether Bridelia is a good idea for someone in your situation. Here is what our Bridelia record says about it on its own.

Bridelia: dosing

There is no established or standardized dose for Bridelia. Traditional preparations vary widely, and product strength is not consistent.If you choose to use a Bridelia product, follow the directions on the label and do not exceed the recommended amount.

From our Bridelia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bridelia monograph & all interactions
Medication

About Chloroprocaine

What Is Chloroprocaine Used For?

Brand names: Nesacaine, Nescaine-MPF

Chloroprocaine injection is used to produce local anesthesia — numbing — for a range of medical and surgical procedures. The specific uses depend on the product and concentration.

Nesacaine 1% and 2% (multidose vials with preservative) are approved for infiltration (numbing tissue directly) and peripheral nerve block only — not for epidural use. Nesacaine-MPF 2% and 3% (preservative-free, single-dose vials) are approved for infiltration, peripheral nerve block, and central nerve block, including lumbar and caudal epidural anesthesia. Chloroprocaine hydrochloride injection 2% and 3% (single-dose, preservative-free vials) are similarly approved for infiltration, peripheral and central nerve block, including lumbar and caudal epidural blocks. Iheezo, the ophthalmic gel, is used to numb the surface of the eye before procedures on or near the eye.

See full Chloroprocaine drug information
Keep checking

Other Drugs & Bridelia

Browse every other medication we’ve checked against Bridelia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
330Moderate
0Minor
2,499No known interaction
330 Moderate 2,499 No interaction
Moderate

330 interactions

Showing 60 of 330 moderate interactions — see all 330 on the Bridelia page.

No interaction 2,499 drugs checked — show the list

We also checked Bridelia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,499 medications checked with no known interaction — see the full Bridelia list.

See the full Bridelia interactions page
See every supplement checked against Chloroprocaine, ranked by severity
Evidence & sources

Bridelia References

The 4 references that drive our Bridelia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Corallo A, Foungbe S, Davy M, Cohen Y. Cardiovascular pharmacology of aqueous extract of the leaves of Bridelia atroviridis Muell. Arg. (Euphorbiaceae) in the rat. J Ethnopharmacol 1997;57(3):189-96. PubMed
  2. Njamen D, Magne Nde CB, Tanee Fomum Z, Vollmer G. Effects of the extracts of some tropical medicinal plants on estrogen inducible yeast and Ishikawa screens, and on ovariectomized Wistar rats. Pharmazie 2008;63(2):164-8. DOI
  3. Corallo A, Savineau JP, Tricoche R, Foungbe S. The uterotonic action of the aqueous extract of Bridelia atroviridis in the rat. Fundam Clin Pharmacol 1991;5(4):319-29. PubMed
  4. Olajide, O. A. Investigation of the effects of selected medicinal plants on experimental thrombosis. Phytother Res 1999;13(3):231-232. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bridelia and Chloroprocaine Together: Common Questions

Is it safe to take Bridelia with Chloroprocaine?
We do not list a known interaction between Bridelia and Chloroprocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Bridelia and Chloroprocaine combination checked?
Interactions in our licensed database are recorded against drug classes. Chloroprocaine is filed under 1 classification, and Bridelia has documented interactions with 3 drug classes — none of Chloroprocaine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bridelia interact with any other medications?
Yes. Bridelia has 330 documented drug interactions in our database — Chloroprocaine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Chloroprocaine interact with any supplements?
Yes. Chloroprocaine has documented interactions with 5 supplements in our database — Bridelia is not one of them. The Chloroprocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bridelia monograph Uses, safety profile, and every drug interaction in one place Chloroprocaine drug information The full plain-English guide to this medication Chloroprocaine supplement interactions Every supplement checked against Chloroprocaine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Chloroprocaine and Bridelia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.