Bupleurum - Zegalogue (Dasiglucagon Hydrochloride) Interaction
Herbal: Bupleurum
Also Known As: Bei Chai Hu, Bupleuri, Bupleurum Chinese, Buplèvre, Buplèvre Chinois, Buplèvre à Feuilles Rondes, Buplèvre à Feuilles de Scorsonère, Buplèvre à Longues Feuilles, Buplèvre Ligneux, Chai Hu, Chi Hu, Chinese Bupleurum, Chinese Thoroughwax, Hare's Ear Root, Radix Bupleuri
Drug: Dasiglucagon Hydrochloride
Brand names:
Zegalogue
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Dasiglucagon Hydrochloride is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, bupleurum might decrease the effects of antidiabetes drugs.
Animal research suggests that saikosaponins, constituents of bupleurum, can increase blood glucose.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Hiai S, Yokoyama H, Nagasawa T, and et al. Stimulation of the pituitary-adrenocortical axis by saikosaponin of Bupleuri radix. Chemical and Pharmaceutical Bulletin (Tokyo) 1981;29(2):495-499.
- Yokoyama H, Hiai S, and Oura H. Chemical structures and corticosterone secretion-inducing activities of saikosaponins. Chem Pharm Bull (Tokyo) 1981;29(2):500-504.
Bupleurum Overview
Bupleurum is a plant that is native to Asia and Europe. It is a member of the carrot family (Apiaceae) and is known for its small, yellow flowers and thin, spiky leaves.
In traditional medicine, bupleurum is believed to have anti-inflammatory and pain-relieving effects and is used to treat a variety of conditions, including pain, digestive problems, respiratory infections, and skin disorders.
Bupleurum is also believed to have a number of other medicinal properties, including the ability to improve immune function, reduce the risk of heart disease, and lower cholesterol levels. Bupleurum is often used in conjunction with other ingredients in traditional Chinese herbal dietary supplements.
Dasiglucagon Hydrochloride Overview
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Dasiglucagon injection is used along with emergency medical treatment to treat severe hypoglycemia (very low blood sugar) in adults and children 6 years of age and older with diabetes. Dasiglucagon injection is in a class of medications called glucagon receptor agonists. It works by causing the liver to release stored sugar to the blood.
Bupleurum - More Interactions
Bupleurum interacts with 315 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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