Drug & supplement interaction

Bupleurum + Ombitasvir, Paritaprevir Ritonavir

Ombitasvir, Paritaprevir Ritonavir brand name: Technivie.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bupleurum and Ombitasvir, Paritaprevir Ritonavir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bupleurum and Ombitasvir, Paritaprevir Ritonavir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ombitasvir, Paritaprevir Ritonavir and Bupleurum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bupleurum safety at a glance

Bupleurum overall Use caution Generally used short-term in formulas, but it has been linked to rare lung and liver problems and quality varies.
Pregnancy Avoid Not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ombitasvir, Paritaprevir Ritonavir and Bupleurum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ombitasvir, Paritaprevir Ritonavir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ombitasvir, Paritaprevir Ritonavir is filed under 7 classifications — including cytochrome p450 3a4 (cyp3a4) inhibitors, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Bupleurum has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Ombitasvir, Paritaprevir Ritonavir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bupleurum Does Interact With Other Medications

Bupleurum has 327 moderate known drug interactions in our database — Ombitasvir, Paritaprevir Ritonavir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 327 No known interaction 2,503 (incl. Ombitasvir, Paritaprevir Ritonavir)
Taking anything else?

Check Another of Your Medications Against Bupleurum

Covers the 2,830 medications we’ve checked against Bupleurum. Pick one to open its full report.

What to actually watch for

What Bupleurum Itself Has Been Linked To

This is not an interaction — nothing below involves Ombitasvir, Paritaprevir Ritonavir. It is the side-effect record for Bupleurum on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Bupleurum, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Liver problems / A higher chance of infection Worth acting on Additional detail

    “Orally, combination products containing bupleurum have been reported to cause eosinophilic pneumonia, pulmonary edema, and multiple cases of pneumonitis. A specific combination product (sho-saiko-to), used in combination with interferon-alpha in patients with chronic active hepatitis, has also been associated with multiple cases of pneumonitis.”

    Bupleurum · Natural Medicines adverse-effect record, reported in hepatitis.

    6 sources cited
    1. 354. Kobashi Y, Nakajima M, Niki Y, Matsushima T. [A case of acute eosinophilic pneumonia due to Sho-saiko-to]. Nippon Kyobu Shikkan Gakkai Zasshi 1997;35:1372-7.
    2. 361. Miyazaki E, Ando M, Ih K, et al. [Pulmonary edema associated with the Chinese medicine shosaikoto]. Nihon Kokyuki Gakkai Zasshi 1998;36:776-80.
    3. 355. Wada Y, Kubo M. [Acute lymphoblastic leukemia complicated by type C hepatitis during treatment and further by acute interstitial pneumonia due to sho-saiko-to in 7-year-old]. Arerugi 1997;46:1148-55.
    4. 356. Sato A, Toyoshima M, Kondo A, et al. [Pneumonitis induced by the herbal medicine Sho-saiko-to in Japan]. Nippon Kyobu Shikkan Gakkai Zasshi 1997;35:391-5.
    5. 357. Daibo A, Yoshida Y, Kitazawa S, et al. [A case of pneumonitis and hepatic injury caused by a herbal drug (sho-saiko-to)]. Nippon Kyobu Shikkan Gakkai Zasshi 1992;30:1583-8.
    6. 37404. Sugiyama H, Nagai M, Kotajima F, and et al. [A case of interstitial pneumonia with chronic hepatitis C following interferon-alfa and sho-saiko-to therapy]. Arerugi 1995;44(7):711-714.
  • Numbness or tingling / Tiredness Additional detail

    “Orally, a specific bupleurum-containing combination product (sho-saiko-to) has been reported to cause fatigue and paresthesia. It is unclear if these adverse effects are due to bupleurum, other ingredients, or the combination.”

    Bupleurum · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 37391. Hirayama, C., Okumura, M., Tanikawa, K., and et al. A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis. Gastroenterol Jpn 1989;24(6):715-719. PubMed
  • Reduced appetite / Nausea Additional detail

    “Orally, a specific bupleurum-containing combination product (sho-saiko-to) has been reported to cause nausea, anorexia, and abdominal fullness. It is unclear if these adverse effects are due to bupleurum, other ingredients, or the combination.”

    Bupleurum · Natural Medicines adverse-effect record, reported in anorexia.

    1 source cited
    1. 37391. Hirayama, C., Okumura, M., Tanikawa, K., and et al. A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis. Gastroenterol Jpn 1989;24(6):715-719. PubMed
  • Swelling Additional detail

    Recorded for Bupleurum in the same Natural Medicines adverse-effect record shown under Liver problems / A higher chance of infection above.

Everything above comes from the Natural Medicines adverse-effect record for Bupleurum — expand a row for the licensed statement it rests on. We haven’t matched Ombitasvir, Paritaprevir Ritonavir to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Ombitasvir, Paritaprevir Ritonavir.

Everything else you take

See Every Supplement That Interacts With Ombitasvir, Paritaprevir Ritonavir

This page covers Bupleurum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ombitasvir, Paritaprevir Ritonavir page lists 154 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,4-butanediol (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 113 moderate · 38 minor.

From our pharmacist’s overview on the Ombitasvir, Paritaprevir Ritonavir page

“Technivie (ombitasvir, paritaprevir, and ritonavir) treats hepatitis C, and because a cure depends on holding steady drug levels for the whole course, this list warrants genuine care. Most of the 154 ingredients on file touch the CYP3A4 enzyme pathway, meaning they can push the drug's blood levels up or down.”

Reviewed by 2 · Jul 18, 2026

Open the Ombitasvir, Paritaprevir Ritonavir interaction page

One more smart check

Taking Bupleurum as Part of a Dietary Supplement Product? Check It for Interactions

We hold 89 real supplement products containing Bupleurum, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bupleurum. Even though Bupleurum itself has no known interaction with Ombitasvir, Paritaprevir Ritonavir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bupleurum and Ombitasvir, Paritaprevir Ritonavir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bupleurum
Top half

#404 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ombitasvir, Paritaprevir Ritonavir
Steady interest

#1,625 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bupleurum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bupleurum and Ombitasvir, Paritaprevir Ritonavir records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bupleurum

What is Bupleurum?

Bupleurum
  • Liver and digestive support
  • Cold, flu, and fever
  • Inflammation
  • Stress and mood
  • Immune support

Bupleurum (Chai Hu) is a root used in traditional Chinese medicine, usually as part of multi-herb formulas, for liver, digestive, and fever-related complaints. High-quality human evidence for its benefits is limited, and it has been linked to lung and liver problems in some reports, so use it cautiously and only under professional guidance.

Bupleurum chinense · Apiaceae · Root · Capsules, tablets, dried root, teas, tinctures, and traditional Chinese herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Bupleurum is a good idea for someone in your situation. Here is what our Bupleurum record says about it on its own.

Bupleurum: dosing

There is no well-established standard dose of Bupleurum. Do not exceed the recommended amount, and avoid long-term use without professional guidance.

From our Bupleurum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bupleurum monograph & all interactions
Medication

About Ombitasvir, Paritaprevir, and Ritonavir

What Is Ombitasvir, Paritaprevir, and Ritonavir Used For?

Brand name: Technivie

  • The combination of ombitasvir, paritaprevir, and ritonavir is usually used in combination with ribavirin (Copegus, Rebetol), but sometimes it is used alone to treat a certain type of chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus). Ombitasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Paritaprevir is a protease inhibitor. It works by decreasing the amount of HCV in the body. Ritonavir is a protease inhibitor. It helps to increase the amount of paritaprevir in the body so that the medication will have a greater effect. It is not known if ombitasvir, paritaprevir, or ritonavir prevent the spread of hepatitis C to other people.

See full Ombitasvir, Paritaprevir, and Ritonavir drug information
Keep checking

Other Drugs & Bupleurum

Browse every other medication we’ve checked against Bupleurum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
327Moderate
0Minor
2,502No known interaction
327 Moderate 2,502 No interaction
Moderate

327 interactions

Showing 60 of 327 moderate interactions — see all 327 on the Bupleurum page.

No interaction 2,502 drugs checked — show the list

We also checked Bupleurum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Bupleurum list.

See the full Bupleurum interactions page
See every supplement checked against Ombitasvir, Paritaprevir Ritonavir, ranked by severity
Evidence & sources

Bupleurum References

The 17 references that drive our Bupleurum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kobashi Y, Nakajima M, Niki Y, Matsushima T. [A case of acute eosinophilic pneumonia due to Sho-saiko-to]. Nippon Kyobu Shikkan Gakkai Zasshi 1997;35:1372-7.
  2. Wada Y, Kubo M. [Acute lymphoblastic leukemia complicated by type C hepatitis during treatment and further by acute interstitial pneumonia due to sho-saiko-to in 7-year-old]. Arerugi 1997;46:1148-55.
  3. Sato A, Toyoshima M, Kondo A, et al. [Pneumonitis induced by the herbal medicine Sho-saiko-to in Japan]. Nippon Kyobu Shikkan Gakkai Zasshi 1997;35:391-5.
  4. Daibo A, Yoshida Y, Kitazawa S, et al. [A case of pneumonitis and hepatic injury caused by a herbal drug (sho-saiko-to)]. Nippon Kyobu Shikkan Gakkai Zasshi 1992;30:1583-8.
  5. Sugiyama H, Nagai M, Kotajima F, et al. [A case of interstitial pneumonia with chronic hepatitis C following interferon-alfa and sho-saiko-to therapy]. Arerugi 1995;44:711-4.
  6. Ishizaki T, Sasaki F, Ameshima S, et al. Pneumonitis during interferon and/or herbal drug therapy in patients with chronic active hepatitis. Eur Respir J 1996;9:2691-6. PubMed
  7. Nakagawa A, Yamaguchi T, Takao T, Amano H. [Five cases of drug induced pneumonitis due to Sho-saiko-to or interferon-alpha or both]. Nippon Kyobu Shikkan Gakkai Zasshi 1995;33:1361-6.
  8. Miyazaki E, Ando M, Ih K, et al. [Pulmonary edema associated with the Chinese medicine shosaikoto]. Nihon Kokyuki Gakkai Zasshi 1998;36:776-80.
  9. Matsumoto T, Yamada H. Regulation of immune complexes binding of macrophages by pectic polysaccharide from Bupleurum falcatum L.: pharmacological evidence for the requirement of intracellular calcium/calmodulin on Fc receptor up-regulation by bupleuran 2
  10. Hattori T, Ito M, Suzuki Y. [Studies on antinephritic effects of plant components in rats (1). Effects of saikosaponins original-type anti-GBM nephritis in rats and its mechanisms]. Nippon Yakurigaku Zasshi 1991;97:13-21. PubMed
  11. Chang WC, Hsu FL. Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds. Prostaglandins Leukot Essent Fatty Acids 1991;44:51-6. PubMed
  12. Kato M, Pu MY, Isobe K, et al. Characterization of the immunoregulatory action of saikosaponin-d. Cell Immunol 1994;159:15-25. PubMed
  13. Ushio Y, Oda Y, Abe H. Effect of saikosaponin on the immune responses in mice. Int J Immunopharmacol 1991;13:501-8. PubMed
  14. Hirayama, C., Okumura, M., Tanikawa, K., and et al. A multicenter randomized controlled clinical trial of Shosaiko-to in chronic active hepatitis. Gastroenterol Jpn 1989;24(6):715-719. PubMed
  15. Hiai S, Yokoyama H, Nagasawa T, and et al. Stimulation of the pituitary-adrenocortical axis by saikosaponin of Bupleuri radix. Chemical and Pharmaceutical Bulletin (Tokyo) 1981;29(2):495-499. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bupleurum and Ombitasvir, Paritaprevir Ritonavir Together: Common Questions

Is it safe to take Bupleurum with Ombitasvir, Paritaprevir Ritonavir?
We do not list a known interaction between Bupleurum and Ombitasvir, Paritaprevir Ritonavir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Bupleurum and Ombitasvir, Paritaprevir Ritonavir combination checked?
Interactions in our licensed database are recorded against drug classes. Ombitasvir, Paritaprevir Ritonavir is filed under 7 classifications, and Bupleurum has documented interactions with 3 drug classes — none of Ombitasvir, Paritaprevir Ritonavir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bupleurum interact with any other medications?
Yes. Bupleurum has 327 documented drug interactions in our database — Ombitasvir, Paritaprevir Ritonavir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ombitasvir, Paritaprevir Ritonavir interact with any supplements?
Yes. Ombitasvir, Paritaprevir Ritonavir has documented interactions with 154 supplements in our database — Bupleurum is not one of them. The Ombitasvir, Paritaprevir Ritonavir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bupleurum monograph Uses, safety profile, and every drug interaction in one place Ombitasvir, Paritaprevir, and Ritonavir drug information The full plain-English guide to this medication Ombitasvir, Paritaprevir Ritonavir supplement interactions Every supplement checked against Ombitasvir, Paritaprevir Ritonavir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 17 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ombitasvir, Paritaprevir Ritonavir and Bupleurum?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.