Cod Liver Oil - Fotivda (Tivozanib Hydrochloride) Interaction
Herbal: Cod Liver Oil
Drug: Tivozanib Hydrochloride
Brand names:
Fotivda
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Tivozanib Hydrochloride is classified as belonging to the following category: Anticoagulant/Antiplatelet Drugs
Theoretically, cod liver oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
High doses of cod liver oil, 20-40 mL daily, have been associated with prolonged bleeding time and reduced platelet aggregation in healthy volunteers.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Brox JH, Killie JE, Gunnes S, Nordoy A. The effect of cod liver oil and corn oil on platelets and vessel wall in man. Thromb Haemost 1981;46:604-11.
- Sanders TA, Vickers M, Haines AP. Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentainoic and docosahexaenoic acids, in healthy young men. Clin Sci (Colch) 1981;61:317-24.
- Brox JH, Killie JE, Osterud B, et al. Effects of cod liver oil on platelets and coagulation in familial hypercholesterolemia (type IIa). Acta Med Scand 1983;213:137-44..
- Lorenz R, Spengler U, Fischer S, Duhm J, Weber PC. Platelet function, thromboxane formation and blood pressure control during supplementation of the Western diet with cod liver oil. Circulation 1983;67(3):504-11.
- Ahmed AA, Holub BJ. Alteration and recovery of bleeding times, platelet aggregation and fatty acid composition of individual phospholipids in platelets of human subjects receiving a supplement of cod-liver oil. Lipids 1984;19(8):617-24.
Cod Liver Oil Overview
Cod liver oil is derived from the liver of the Atlantic cod fish. It is a rich source of omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as vitamins A and D.
Cod liver oil is used as a dietary supplement to provide the health benefits of omega-3 fatty acids and vitamins A and D. Omega-3 fatty acids are important for maintaining heart health and can help to reduce inflammation, lower blood pressure and triglyceride levels, and may decrease the risk of heart disease.
While Cod liver oil and fish oil are both sources of EPA and DHA, there are some key differences between the two. For example, cod liver oil is derived from the liver of the Atlantic cod fish, while fish oil is typically derived from the body tissue of oily fish such as salmon, sardines, and anchovies.
Additionally, cod liver oil generally has a stronger fishy taste and smell than fish oil due to its liver source.
Tivozanib Hydrochloride Overview
-
Tivozanib is used to treat advanced renal cell carcinoma (RCC; cancer that begins in the kidneys) that has returned or did not respond to at least two other medications. Tivozanib is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.
Cod Liver Oil - More Interactions
Cod Liver Oil interacts with 370 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist