Medication interaction hub

What Supplements Interact with Tivozanib Hydrochloride?

Tivozanib Hydrochloride brand name: Fotivda. Every interaction below applies to the brands too.

288 Interactions 7 Major 239 Moderate 42 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tivozanib Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tivozanib Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tivozanib (Fotivda), an oral targeted therapy for advanced kidney cancer, has a supplement list that calls for genuine vigilance. Seven of the 288 ingredients on file are rated major, and those seven deserve your attention first. Most entries do one of two things: they carry blood-thinning effects that can add bleeding risk, or they alter the CYP3A4 enzyme that clears tivozanib. Grapefruit can push the drug's level up, while St. John's wort can pull it down far enough to weaken the treatment itself.

People going through cancer treatment often reach for herbal blends, CBD, or fiber supplements without a second thought, and that is where the risk hides. A few entries, Siberian cocklebur among them, can strain the kidneys, no small matter for someone treated for kidney cancer. Bulky fibers and charcoal can blunt absorption of the pill, so keep those well apart from your dose. The remaining 239 moderate and 42 minor entries still merit a check against the full list below.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 239 Minor 42 No known interaction 1,164

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tivozanib Hydrochloride: Top Interactions at a Glance

The Tivozanib Hydrochloride supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 288 interacting ingredients — plus 1,164 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tivozanib Hydrochloride Combinations Today

The Tivozanib Hydrochloride + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Black Tea + Tivozanib Hydrochloridei

Theoretically, black tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Eleuthero + Tivozanib Hydrochloridei

Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Ginger + Tivozanib Hydrochloridei

Ginger might increase or decrease the levels of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Unlikely Cola Nut + Tivozanib Hydrochloridei

Theoretically, cola nut may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Vanadium + Tivozanib Hydrochloridei

Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Oregano + Tivozanib Hydrochloridei

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Tivozanib Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 288 with a Tivozanib Hydrochloride interaction on file and 1,164 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tivozanib Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Tea with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Black Tea + Tivozanib Hydrochloride answer

Can you take Eleuthero with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drug...

Full Eleuthero + Tivozanib Hydrochloride answer

Can you take Ginger with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Tivozanib Hydrochloride answer

Can you take Cola Nut with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cola nut may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cola Nut + Tivozanib Hydrochloride answer

Can you take Vanadium with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Vanadium + Tivozanib Hydrochloride answer

Can you take Tocotrienols with Tivozanib Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding.

Full Tocotrienols + Tivozanib Hydrochloride answer

Can you take Umckaloabo with Tivozanib Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Pelargonium sidoides might increase the risk of bleeding when taken with anticoagulant and antiplatelet drugs.

Full Umckaloabo + Tivozanib Hydrochloride answer

Can you take Grapefruit with Tivozanib Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Tivozanib Hydrochloride answer

Can you take Siberian Cocklebur with Tivozanib Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Siberian cocklebur can adversely affect the kidney.

Full Siberian Cocklebur + Tivozanib Hydrochloride answer

Can you take Activated Charcoal with Tivozanib Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Tivozanib Hydrochloride answer

Can you take Danshen with Tivozanib Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Danshen + Tivozanib Hydrochloride answer

Can you take Piracetam with Tivozanib Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, concomitant use of piracetam and anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Piracetam + Tivozanib Hydrochloride answer

Can you take St. John's Wort with Tivozanib Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. St.

Full St. John's Wort + Tivozanib Hydrochloride answer

Can you take Asarabacca with Tivozanib Hydrochloride?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Asarabacca, a herbaceous plant, is often contaminated with aristolochic acid, a compound known for its nephrotoxic effects.

Full Asarabacca + Tivozanib Hydrochloride answer

Can you take Bridelia with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animals, orally administered extracts of Bridelia ferruginea stem bark inhibit ADP/adrenaline-induced thrombosis by approximately 62%.The...

Full Bridelia + Tivozanib Hydrochloride answer

Can you take Cannabidiol (cbd) with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cannabidiol may increase levels of drugs that are metabolized by CYP3A4.

Full Cannabidiol (cbd) + Tivozanib Hydrochloride answer

Can you take Coffee Charcoal with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Tivozanib Hydrochloride answer

Can you take European Mandrake with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Tivozanib Hydrochloride answer

Can you take Glucomannan with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Tivozanib Hydrochloride answer

Can you take Guggul with Tivozanib Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might reduce the effects of CYP3A4 substrates.

Full Guggul + Tivozanib Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tivozanib Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tivozanib Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tivozanib Hydrochloride sits in 4 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Tivozanib Hydrochloride through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Tivozanib Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tivozanib Hydrochloride through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Tivozanib Hydrochloride through this category.

About Tivozanib Hydrochloride

Tivozanib is a targeted cancer medicine used to treat advanced renal cell carcinoma (kidney cancer) that has returned or stopped responding to prior treatments.

Generic name: Tivozanib Hydrochloride  ·  Brand name: Fotivda.

See the full Tivozanib drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tivozanib Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tivozanib Hydrochloride.

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Pharmacist Counseling Corner

Tivozanib Hydrochloride & Supplements: Common Questions

What supplements interact with Tivozanib Hydrochloride?
More than you might expect — 288 in total, though they are far from equal: 7 are rated major, 239 moderate, and 42 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Tivozanib Hydrochloride supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Danshen and Piracetam, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Tivozanib Hydrochloride?
Usually yes — most people on Tivozanib Hydrochloride can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Fotivda have the same supplement interactions as Tivozanib Hydrochloride?
Yes — Fotivda all contain Tivozanib Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Tivozanib Hydrochloride and my other medications?
This page covers Tivozanib Hydrochloride against supplements and herbal ingredients. Checking Tivozanib Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tivozanib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.