Medication interaction hub

What Supplements Interact with Ibrutinib?

Ibrutinib brand name: Imbruvica. Every interaction below applies to the brands too.

282 Interactions 5 Major 236 Moderate 41 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ibrutinib? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ibrutinib against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Ibrutinib (Imbruvica) treats blood cancers such as chronic lymphocytic leukemia, and because the drug itself makes bruising and bleeding more likely, adding the wrong supplement here can carry real consequences. Most of the entries below have blood-thinning or antiplatelet activity that stacks on top of that built-in bleeding risk. A second sizable group changes how the liver clears ibrutinib through the CYP3A4 enzyme, so grapefruit can push its blood level up while St. John's wort can pull it down far enough to undercut the cancer treatment.

A smaller cluster interferes with the pill's absorption itself. Activated charcoal rates major for exactly that reason, and bulky fiber supplements can act in a similar way, so space those well apart from your dose. All told the page lists 282 ingredients, most sitting at moderate (236 of them, plus 41 minor), but the five rated major are the ones to understand first.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 236 Minor 41 No known interaction 1,170

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ibrutinib: Top Interactions at a Glance

The Ibrutinib supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 282 interacting ingredients — plus 1,170 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ibrutinib Combinations Today

The Ibrutinib + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Pantethine + Ibrutinibi

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Read the full interaction Minor Likelihood Unlikely Magnesium + Ibrutinibi

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full interaction Moderate Likelihood Possible Bromelain + Ibrutinibi

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Unlikely Docosahexaenoic Acid (dha) + Ibrutinibi

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Gamma-linolenic Acid (gla) + Ibrutinibi

Theoretically, GLA might increase the risk of bleeding when taken with anticoagulant or antiplatelet rugs.

Read the full interaction Moderate Likelihood Possible Quercetin + Ibrutinibi

Theoretically, concomitant use might alter the effects and adverse effects of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Ibrutinib

All 1,452 ingredients in our database, ranked by severity — 282 with a Ibrutinib interaction on file and 1,170 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ibrutinib?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Pantethine with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Pantethine + Ibrutinib answer

Can you take Magnesium with Ibrutinib?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Full Magnesium + Ibrutinib answer

Can you take Bromelain with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Ibrutinib answer

Can you take Docosahexaenoic Acid (dha) with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Docosahexaenoic Acid (dha) + Ibrutinib answer

Can you take Gamma-linolenic Acid (gla) with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, GLA might increase the risk of bleeding when taken with anticoagulant or antiplatelet rugs.

Full Gamma-linolenic Acid (gla) + Ibrutinib answer

Can you take Dandelion with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.

Full Dandelion + Ibrutinib answer

Can you take Delta-9-tetrahydrocannabinol (thc) with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, THC might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.

Full Delta-9-tetrahydrocannabinol (thc) + Ibrutinib answer

Can you take Devil's Claw with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.

Full Devil's Claw + Ibrutinib answer

Can you take Dhea with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.

Full Dhea + Ibrutinib answer

Can you take Dimethylsulfoxide (dmso) with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, DMSO might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Dimethylsulfoxide (dmso) + Ibrutinib answer

Can you take Diosmin with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.

Full Diosmin + Ibrutinib answer

Can you take Dong Quai with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflict...

Full Dong Quai + Ibrutinib answer

Can you take Echinacea with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.

Full Echinacea + Ibrutinib answer

Can you take Eicosapentaenoic Acid (epa) with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, EPA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Eicosapentaenoic Acid (epa) + Ibrutinib answer

Can you take Eleuthero with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drug...

Full Eleuthero + Ibrutinib answer

Can you take Eucalyptus with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.

Full Eucalyptus + Ibrutinib answer

Can you take European Barberry with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, European barberry might increase the levels and clinical effects of CYP3A4 substrates.

Full European Barberry + Ibrutinib answer

Can you take Evening Primrose with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evening primrose oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Evening Primrose + Ibrutinib answer

Can you take Evodia with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, evodia might increase the levels and clinical effects of CYP3A4 substrates.

Full Evodia + Ibrutinib answer

Can you take False Unicorn with Ibrutinib?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, false unicorn extract inhibits cytochrome P450 3A4 (CYP3A4) activity.

Full False Unicorn + Ibrutinib answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ibrutinib is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ibrutinib, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ibrutinib sits in 3 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Ibrutinib through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ibrutinib through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ibrutinib through this category.

About Ibrutinib

Ibrutinib is a targeted cancer medicine used to treat certain blood cancers and a chronic immune complication called chronic graft-versus-host disease.

Generic name: Ibrutinib  ·  Brand name: Imbruvica.

See the full Ibrutinib drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ibrutinib

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ibrutinib.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Ibrutinib & Supplements: Common Questions

What supplements interact with Ibrutinib?
Our database currently documents 282 ingredients with a known Ibrutinib interaction (5 major, 236 moderate, 41 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 282. The highest-ranked right now: Grapefruit, Activated Charcoal, Danshen.
Which Ibrutinib supplement interactions are the most serious?
Focus on the major group: Grapefruit, Activated Charcoal, Danshen, Piracetam and St. John's Wort. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ibrutinib?
Plenty of supplements coexist fine with Ibrutinib; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Imbruvica have the same supplement interactions as Ibrutinib?
Yes — Imbruvica all contain Ibrutinib, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ibrutinib and my other medications?
This page covers Ibrutinib against supplements and herbal ingredients. Checking Ibrutinib against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Ibrutinib drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.