Medication interaction hub

What Supplements Interact with Rivaroxaban?

Rivaroxaban brand name: Xarelto. Every interaction below applies to the brands too.

285 Interactions 5 Major 240 Moderate 40 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Rivaroxaban? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Rivaroxaban against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit is the interaction I would flag first for anyone taking rivaroxaban (Xarelto). It slows how the body clears this blood thinner, and higher levels mean more bleeding risk. Most of the page follows suit. Of the 285 supplements and herbs on file, more than 200 have some blood-thinning or anti-clotting activity of their own, which compounds an anticoagulant's effect. This is a list that deserves real care, not a quick skim.

Five entries rate major, and they pull in different directions. St. John's wort speeds rivaroxaban's breakdown, which could leave you underprotected against a clot, while activated charcoal can keep a dose from absorbing at all. The other two majors add bleeding effects of their own. The 240 moderate and 40 minor entries mostly repeat these themes on a smaller scale. With a blood thinner, an error in either direction matters, so understand the five majors first.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 240 Minor 40 No known interaction 1,167

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Rivaroxaban: Top Interactions at a Glance

The Rivaroxaban supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 285 interacting ingredients — plus 1,167 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Rivaroxaban Combinations Today

The Rivaroxaban + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Beet + Rivaroxabani

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Minor Likelihood Unlikely Magnesium + Rivaroxabani

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Read the full interaction Moderate Likelihood Possible Cranberry + Rivaroxabani

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Oregano + Rivaroxabani

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Flaxseed + Rivaroxabani

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.

Read the full interaction Moderate Likelihood Possible Turmeric + Rivaroxabani

Turmeric might increase or decrease levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Rivaroxaban

All 1,452 ingredients in our database, ranked by severity — 285 with a Rivaroxaban interaction on file and 1,167 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Rivaroxaban?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Beet with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Rivaroxaban answer

Can you take Magnesium with Rivaroxaban?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.

Full Magnesium + Rivaroxaban answer

Can you take Cranberry with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Rivaroxaban answer

Can you take Oregano with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Oregano + Rivaroxaban answer

Can you take Flaxseed with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of b...

Full Flaxseed + Rivaroxaban answer

Can you take Black Currant with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black currant seed oil might increase the risk of bleeding if used in combination with anticoagulant or antiplatelet drugs.

Full Black Currant + Rivaroxaban answer

Can you take Black Pepper with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Rivaroxaban answer

Can you take Black Seed with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black seed may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Black Seed + Rivaroxaban answer

Can you take Black Tea with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black tea may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Black Tea + Rivaroxaban answer

Can you take Blood Irradiation Therapy with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research suggests that blood irradiation therapy might reduce platelet aggregation.

Full Blood Irradiation Therapy + Rivaroxaban answer

Can you take Bog Labrador Tea with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that aqueous and ethanolic extracts of Bog Labrador tea leaves can increase the concentration of cytochrome P450 3A4...

Full Bog Labrador Tea + Rivaroxaban answer

Can you take Boldo with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Boldo + Rivaroxaban answer

Can you take Borage with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Borage + Rivaroxaban answer

Can you take Boswellia Serrata with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.

Full Boswellia Serrata + Rivaroxaban answer

Can you take Breadfruit with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Full Breadfruit + Rivaroxaban answer

Can you take Bromelain with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Bromelain + Rivaroxaban answer

Can you take Buchu with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu may have antiplatelet effects.

Full Buchu + Rivaroxaban answer

Can you take Bulbine Natalensis with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Rivaroxaban answer

Can you take Bupleurum with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Bupleurum + Rivaroxaban answer

Can you take Burdock with Rivaroxaban?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

Full Burdock + Rivaroxaban answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Rivaroxaban is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Rivaroxaban, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Rivaroxaban sits in 5 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Rivaroxaban through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Rivaroxaban through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Rivaroxaban through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Rivaroxaban through this category.

Rivaroxaban (Xarelto) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Rivaroxaban through this category.

About Rivaroxaban

Rivaroxaban is a blood thinner that treats and prevents blood clots in the legs, lungs, and other areas.

Generic name: Rivaroxaban  ·  Brand name: Xarelto.

See the full Rivaroxaban drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Rivaroxaban

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Rivaroxaban.

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Pharmacist Counseling Corner

Rivaroxaban & Supplements: Common Questions

What supplements interact with Rivaroxaban?
More than you might expect — 285 in total, though they are far from equal: 5 are rated major, 240 moderate, and 40 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Activated Charcoal, Danshen.
Which Rivaroxaban supplement interactions are the most serious?
The 5 major-rated combinations — led by Grapefruit, Activated Charcoal, Danshen, Piracetam and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Rivaroxaban?
Usually yes — most people on Rivaroxaban can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Xarelto have the same supplement interactions as Rivaroxaban?
Yes — Xarelto all contain Rivaroxaban, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Rivaroxaban and my other medications?
This page covers Rivaroxaban against supplements and herbal ingredients. Checking Rivaroxaban against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Rivaroxaban drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.