Drug & supplement interaction

Eyebright + Melphalan Flufenamide

Melphalan Flufenamide brand name: Pepaxto.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Eyebright and Melphalan Flufenamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Eyebright and Melphalan Flufenamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Melphalan Flufenamide and Eyebright in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Eyebright safety at a glance

Eyebright overall Use caution Likely safe in small amounts as a tea, but using homemade or non-sterile preparations directly in the eye is risky.
Pregnancy Avoid Safety has not been established, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Melphalan Flufenamide and Eyebright? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Melphalan Flufenamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Melphalan Flufenamide is filed under a single classification — alkylating agents. Eyebright has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Melphalan Flufenamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Eyebright Does Interact With Other Medications

Eyebright has 86 moderate known drug interactions in our database — Melphalan Flufenamide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Melphalan Flufenamide)
Taking anything else?

Check Another of Your Medications Against Eyebright

Covers the 2,830 medications we’ve checked against Eyebright. Pick one to open its full report.

What to actually watch for

What Eyebright Itself Has Been Linked To

This is not an interaction — nothing below involves Melphalan Flufenamide. It is the side-effect record for Eyebright on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Eyebright, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Confusion Worth acting on Additional detail

    “Orally, eyebright has been reported to cause confusion and headache (4).”

    Eyebright · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  • Shortness of breath Worth acting on Additional detail

    “Orally, eyebright has been reported to cause cough, dyspnea, and nasal congestion (4).”

    Eyebright · Natural Medicines adverse-effect record, reported in cough.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  • A stuffy or runny nose / Cough Additional detail

    Recorded for Eyebright in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

  • Blurred vision / Itching / Swelling Additional detail

    “Topically, eyebright has been reported to cause increased ocular pressure, lacrimation, pruritus, redness, swelling of eyelid margins, vision changes, and photophobia when applied to the eyes (4). Ophthalmic eyebright products should be used with caution due to the potential for contamination (8,11).”

    Eyebright · Natural Medicines adverse-effect record, reported in pruritus.

    3 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 8. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
    3. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  • Constipation / Nausea Additional detail

    “Orally, eyebright has been reported to cause nausea and constipation (4).”

    Eyebright · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  • Headache Additional detail

    Recorded for Eyebright in the same Natural Medicines adverse-effect record shown under Confusion above.

Everything above comes from the Natural Medicines adverse-effect record for Eyebright — expand a row for the licensed statement it rests on. We haven’t matched Melphalan Flufenamide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Melphalan Flufenamide.

Overlapping uses

What Melphalan Flufenamide Is Prescribed For, and What Eyebright Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Melphalan Flufenamide is a prescription medicine with approved uses on its FDA label. Eyebright is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Eyebright has been studied for:

  • Cancer studied, not established Eyebright has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Eyebright for cancer

    Although there has been interest in using oral eyebright for cancer, there is insufficient reliable information about the clinical effects of eyebright for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Melphalan Flufenamide on your own; if you are taking Eyebright for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Melphalan Flufenamide

This page covers Eyebright only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Melphalan Flufenamide page lists 7 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Acerola (moderate), Alpha-lipoic Acid (moderate), Coenzyme Q10 (moderate), Rose Hip (moderate) and Turmeric (moderate).

By severity: 7 moderate.

From our pharmacist’s overview on the Melphalan Flufenamide page

“The single most important thing on this page is antioxidants. Melphalan flufenamide (Pepaxto) is a chemotherapy used for multiple myeloma, and part of how it kills cancer cells is by generating free radicals.”

Reviewed by 2 · Jul 18, 2026

Open the Melphalan Flufenamide interaction page

One more smart check

Taking Eyebright as Part of a Dietary Supplement Product? Check It for Interactions

We hold 504 real supplement products containing Eyebright, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Eyebright. Even though Eyebright itself has no known interaction with Melphalan Flufenamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Eyebright and Melphalan Flufenamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Eyebright
Top half

#365 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Melphalan Flufenamide
Top half

#889 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Eyebright reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Eyebright and Melphalan Flufenamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Eyebright

What is Eyebright?

Eyebright
  • Eye irritation and redness
  • Conjunctivitis (pink eye)
  • Eye strain
  • Allergy and cold-related eye symptoms
  • Nasal congestion and hay fever

Eyebright is a traditional herb long used for minor eye irritation, redness, and allergy symptoms, but high-quality human studies are very limited. There is not enough reliable evidence to confirm it works, and using non-sterile herbal preparations in the eye carries a real risk of infection, so talk to your pharmacist or doctor before trying it.

Euphrasia officinalis · Orobanchaceae · Aerial parts (leaves, stems, and flowers) · Tea, eye drops, tincture, capsules, homeopathic preparations, compresses

An interaction check asks whether these two react with each other — it does not ask whether Eyebright is a good idea for someone in your situation. Here is what our Eyebright record says about it on its own.

Eyebright: dosing

There is no standardized or well-established dose for eyebright. Traditional use as a tea typically involves steeping the dried herb in hot water, but amounts vary widely between products and sources.If you choose to use a commercial eyebright product, follow the directions on the label and choose products from reputable manufacturers. For anything used in or near the eye, only use products that are specifically made and labeled as sterile eye preparations.

From our Eyebright monograph — the full record covers uses, side effects and every documented interaction.

Read the full Eyebright monograph & all interactions
Medication

About Melphalan Flufenamide Injection

What Is Melphalan Flufenamide Injection Used For?

Brand name: Pepaxto

  • Melphalan flufenamide injection is used along with dexamethasone to treat multiple myeloma (a type of cancer of the bone marrow) in adults whose disease has returned or has not improved after receiving at least four other chemotherapy medications. Melphalan flufenamide is in a class of medications called alkylating agents. It works by stopping or slowing the growth of cancer cells in your body.

See full Melphalan Flufenamide Injection drug information
Keep checking

Other Drugs & Eyebright

Browse every other medication we’ve checked against Eyebright — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Eyebright page.

No interaction 2,743 drugs checked — show the list

We also checked Eyebright against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Eyebright list.

See the full Eyebright interactions page
See every supplement checked against Melphalan Flufenamide, ranked by severity
Evidence & sources

Eyebright References

The 4 references that drive our Eyebright monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  4. Porchezhian, E., Ansari, S. H., and Shreedharan, N. K. Antihyperglycemic activity of Euphrasia officinale leaves. Fitoterapia 2000;71(5):522-526. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Eyebright and Melphalan Flufenamide Together: Common Questions

Is it safe to take Eyebright with Melphalan Flufenamide?
We do not list a known interaction between Eyebright and Melphalan Flufenamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Eyebright and Melphalan Flufenamide used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Eyebright in each. That is a conversation for your prescriber, especially if Melphalan Flufenamide is being adjusted to a target.
How was the Eyebright and Melphalan Flufenamide combination checked?
Interactions in our licensed database are recorded against drug classes. Melphalan Flufenamide is filed under 1 classification, and Eyebright has documented interactions with 1 drug class — none of Melphalan Flufenamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Eyebright interact with any other medications?
Yes. Eyebright has 86 documented drug interactions in our database — Melphalan Flufenamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Melphalan Flufenamide interact with any supplements?
Yes. Melphalan Flufenamide has documented interactions with 7 supplements in our database — Eyebright is not one of them. The Melphalan Flufenamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Eyebright monograph Uses, safety profile, and every drug interaction in one place Melphalan Flufenamide Injection drug information The full plain-English guide to this medication Melphalan Flufenamide supplement interactions Every supplement checked against Melphalan Flufenamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Melphalan Flufenamide and Eyebright?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.