Drug & supplement interaction

Galphimia Glauca + Pentosan Polysulfate Sodium

Pentosan Polysulfate Sodium brand name: Elmiron.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Galphimia Glauca and Pentosan Polysulfate Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share

Facebook Post Reddit Email

On this page

Interaction report

Galphimia Glauca and Pentosan Polysulfate Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pentosan Polysulfate Sodium and Galphimia Glauca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Galphimia Glauca safety at a glance

Galphimia Glauca overall Use caution Short-term studies suggest it is generally well tolerated, but long-term safety data are limited.

Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.

Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pentosan Polysulfate Sodium and Galphimia Glauca? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Pentosan Polysulfate Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pentosan Polysulfate Sodium is filed under a single classification — oral drugs. Galphimia Glauca has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Pentosan Polysulfate Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Galphimia Glauca Does Interact With Other Medications

Galphimia Glauca has 248 moderate known drug interactions in our database — Pentosan Polysulfate Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Pentosan Polysulfate Sodium)

Taking anything else?

Check Another of Your Medications Against Galphimia Glauca

Covers the 2,830 medications we’ve checked against Galphimia Glauca. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Galphimia Glauca and Pentosan Polysulfate Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Headache reported in 3.4% of FDA reports for Pentosan Polysulfate Sodium Additional detail
Galphimia Glauca
“Orally, Galphimia glauca extract 7-14 mg daily has been associated with sedation and headache. Rarely, restlessness, nervousness, weakness, and other side effects have been reported; but it is unclear if Galphimia glauca was the causal factor.”

Galphimia Glauca · Natural Medicines adverse-effect record, reported in cluster headache.
1 source cited

99507. Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed
Pentosan Polysulfate Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Pentosan Polysulfate Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Nausea reported in 3.9% of FDA reports for Pentosan Polysulfate Sodium Additional detail
Galphimia Glauca
“Orally, Galphimia glauca extract 7-14 mg daily has been associated with nausea and epigastric burning.”

Galphimia Glauca · Natural Medicines adverse-effect record, reported in myasthenia gravis.
1 source cited

99507. Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed
Pentosan Polysulfate Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Pentosan Polysulfate Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Galphimia Glauca but not commonly for Pentosan Polysulfate Sodium: anxiety or restlessness and drowsiness.

Effects for Pentosan Polysulfate Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Galphimia Glauca come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 6,854 voluntary FDA FAERS reports for Pentosan Polysulfate Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Pentosan Polysulfate Sodium

This page covers Galphimia Glauca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pentosan Polysulfate Sodium page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Pentosan Polysulfate Sodium page

“If you take Elmiron (pentosan polysulfate sodium) for bladder pain from interstitial cystitis, this list deserves real attention, starting with one entry. Activated charcoal, the only major-rated interaction of the 17 on file, soaks up medications in the gut and can reduce how much of a dose ever reaches you.”

Reviewed by 2 · Jul 18, 2026

Open the Pentosan Polysulfate Sodium interaction page

How much people look this up

Where Galphimia Glauca and Pentosan Polysulfate Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Galphimia Glauca

Steady interest

#1,452 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Pentosan Polysulfate Sodium

Steady interest

#1,812 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Galphimia Glauca reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Galphimia Glauca and Pentosan Polysulfate Sodium records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Galphimia Glauca

What is Galphimia Glauca?

Anxiety and stress
Insomnia
Allergic rhinitis and hay fever
Respiratory complaints
Traditionally used as an anticonvulsant

Galphimia glauca is a shrub from Mexico and Central America that has been studied mainly for anxiety, with some small clinical trials suggesting possible benefit. Overall the evidence is still limited and its long-term safety is not well established, so talk with your pharmacist or doctor before using it.

Galphimia glauca · Malpighiaceae · Leaves and aerial parts · Capsules, standardized extracts, tinctures, homeopathic preparations, tea

An interaction check asks whether these two react with each other — it does not ask whether Galphimia Glauca is a good idea for someone in your situation. Here is what our Galphimia Glauca record says about it on its own.

Galphimia Glauca: dosing

There is no well-established standard dose of Galphimia glauca. Clinical studies have used standardized extracts, but products on the market vary widely in their strength and how they are made.Because of this, follow the directions on the product label and do not exceed the recommended amount.

From our Galphimia Glauca monograph — the full record covers uses, side effects and every documented interaction.

Read the full Galphimia Glauca monograph & all interactions

Medication

About Pentosan Polysulfate

What Is Pentosan Polysulfate Used For?

Brand name: Elmiron

Elmiron (pentosan polysulfate sodium) capsules are indicated for the relief of bladder pain or discomfort associated with interstitial cystitis — a chronic condition that causes bladder pressure, bladder pain, and sometimes pelvic pain.

See full Pentosan Polysulfate drug information

Keep checking

Other Drugs & Galphimia Glauca

Browse every other medication we’ve checked against Galphimia Glauca — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

248Moderate

0Minor

2,581No known interaction

248 Moderate 2,581 No interaction

Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Galphimia Glauca page.

No interaction 2,581 drugs checked — show the list

We also checked Galphimia Glauca against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Galphimia Glauca list.

See the full Galphimia Glauca interactions page

See every supplement checked against Pentosan Polysulfate Sodium, ranked by severity

Evidence & sources

Galphimia Glauca References

The 2 references that drive our Galphimia Glauca monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Herrera-Arellano, A., Jimenez-Ferrer, E., Zamilpa, A., et al. Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical trial controlled with lorazepam. Planta Med
Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Galphimia Glauca and Pentosan Polysulfate Sodium Together: Common Questions

Is it safe to take Galphimia Glauca with Pentosan Polysulfate Sodium?

We do not list a known interaction between Galphimia Glauca and Pentosan Polysulfate Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Galphimia Glauca and Pentosan Polysulfate Sodium have any of the same side effects?

Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Galphimia Glauca and Pentosan Polysulfate Sodium combination checked?

Interactions in our licensed database are recorded against drug classes. Pentosan Polysulfate Sodium is filed under 1 classification, and Galphimia Glauca has documented interactions with 1 drug class — none of Pentosan Polysulfate Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Galphimia Glauca interact with any other medications?

Yes. Galphimia Glauca has 248 documented drug interactions in our database — Pentosan Polysulfate Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Pentosan Polysulfate Sodium interact with any supplements?

Yes. Pentosan Polysulfate Sodium has documented interactions with 17 supplements in our database — Galphimia Glauca is not one of them. The Pentosan Polysulfate Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Galphimia Glauca monograph Uses, safety profile, and every drug interaction in one place Pentosan Polysulfate drug information The full plain-English guide to this medication Pentosan Polysulfate Sodium supplement interactions Every supplement checked against Pentosan Polysulfate Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pentosan Polysulfate Sodium and Galphimia Glauca?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.