Drug & supplement interaction

Galphimia Glauca + Voxelotor

Voxelotor brand name: Oxbryta.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Galphimia Glauca and Voxelotor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Galphimia Glauca and Voxelotor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Voxelotor and Galphimia Glauca in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Galphimia Glauca safety at a glance

Galphimia Glauca overall Use caution Short-term studies suggest it is generally well tolerated, but long-term safety data are limited.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Voxelotor and Galphimia Glauca? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Voxelotor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Voxelotor is filed under 3 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Galphimia Glauca has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Voxelotor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Galphimia Glauca Does Interact With Other Medications

Galphimia Glauca has 248 moderate known drug interactions in our database — Voxelotor isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Voxelotor)
Taking anything else?

Check Another of Your Medications Against Galphimia Glauca

Covers the 2,830 medications we’ve checked against Galphimia Glauca. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Galphimia Glauca and Voxelotor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Headache reported in 7.6% of FDA reports for Voxelotor Additional detail

    Galphimia Glauca

    “Orally, Galphimia glauca extract 7-14 mg daily has been associated with sedation and headache. Rarely, restlessness, nervousness, weakness, and other side effects have been reported; but it is unclear if Galphimia glauca was the causal factor.”

    Galphimia Glauca · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 99507. Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed

    Voxelotor

    Listed in the ADVERSE REACTIONS section of the FDA label for Voxelotor, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Nausea reported in 9.0% of FDA reports for Voxelotor Additional detail

    Galphimia Glauca

    “Orally, Galphimia glauca extract 7-14 mg daily has been associated with nausea and epigastric burning.”

    Galphimia Glauca · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 99507. Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed

    Voxelotor

    Listed in the ADVERSE REACTIONS section of the FDA label for Voxelotor, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Galphimia Glauca but not commonly for Voxelotor: anxiety or restlessness and drowsiness.

Effects for Voxelotor come from the ADVERSE REACTIONS section of its FDA label; effects for Galphimia Glauca come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 22,291 voluntary FDA FAERS reports for Voxelotor that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Voxelotor

This page covers Galphimia Glauca only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voxelotor page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Voxelotor page

“Anyone taking voxelotor (Oxbryta) for sickle cell disease should treat this list with real care, because the pattern behind it is unusually consistent. Almost every entry works through CYP3A4, the same liver enzyme that clears voxelotor, so these ingredients can push the drug's blood level higher or pull it lower, either adding side ef…”

Reviewed by 2 · Jul 18, 2026

Open the Voxelotor interaction page

How much people look this up

Where Galphimia Glauca and Voxelotor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Galphimia Glauca
Steady interest

#1,342 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Voxelotor
Steady interest

#2,318 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Galphimia Glauca reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Galphimia Glauca and Voxelotor records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Galphimia Glauca

What is Galphimia Glauca?

Galphimia Glauca
  • Anxiety and stress
  • Insomnia
  • Allergic rhinitis and hay fever
  • Respiratory complaints
  • Traditionally used as an anticonvulsant

Galphimia glauca is a shrub from Mexico and Central America that has been studied mainly for anxiety, with some small clinical trials suggesting possible benefit. Overall the evidence is still limited and its long-term safety is not well established, so talk with your pharmacist or doctor before using it.

Galphimia glauca · Malpighiaceae · Leaves and aerial parts · Capsules, standardized extracts, tinctures, homeopathic preparations, tea

An interaction check asks whether these two react with each other — it does not ask whether Galphimia Glauca is a good idea for someone in your situation. Here is what our Galphimia Glauca record says about it on its own.

Galphimia Glauca: dosing

There is no well-established standard dose of Galphimia glauca. Clinical studies have used standardized extracts, but products on the market vary widely in their strength and how they are made.Because of this, follow the directions on the product label and do not exceed the recommended amount.

From our Galphimia Glauca monograph — the full record covers uses, side effects and every documented interaction.

Read the full Galphimia Glauca monograph & all interactions
Medication

About Voxelotor

What Is Voxelotor Used For?

Brand name: Oxbryta

Oxbryta (voxelotor) is approved to treat sickle cell disease (SCD) in adults and in children as young as 4 years old. It works by targeting the underlying problem in sickle cell disease — the abnormal hemoglobin that causes red blood cells to take on a rigid, sickle shape.

This approval was granted under the FDA's accelerated approval pathway, based on the drug's ability to raise hemoglobin levels. Continued approval may depend on results from confirmatory clinical trials showing broader clinical benefit.

Most-Reported Side Effects for Voxelotor

From FAERS, the FDA’s public side-effect reporting system (22,300 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Sickle cell anaemia with crisis 11,218 reports
Diarrhea 3,187 reports
Nausea 2,016 reports
Headache 1,691 reports
Abdominal pain upper 1,171 reports
See full Voxelotor drug information
Keep checking

Other Drugs & Galphimia Glauca

Browse every other medication we’ve checked against Galphimia Glauca — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the Galphimia Glauca page.

No interaction 2,581 drugs checked — show the list

We also checked Galphimia Glauca against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full Galphimia Glauca list.

See the full Galphimia Glauca interactions page
See every supplement checked against Voxelotor, ranked by severity
Evidence & sources

Galphimia Glauca References

The 2 references that drive our Galphimia Glauca monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Herrera-Arellano, A., Jimenez-Ferrer, E., Zamilpa, A., et al. Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical trial controlled with lorazepam. Planta Med
  2. Herrera-Arellano A, Jiménez-Ferrer JE, Zamilpa A, García-Alonso G, Herrera-Alvarez S, Tortoriello J. Therapeutic effectiveness of Galphimia glauca vs. lorazepam in generalized anxiety disorder. A controlled 15-week clinical trial. Planta Med. 2012;78(14): PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Galphimia Glauca and Voxelotor Together: Common Questions

Is it safe to take Galphimia Glauca with Voxelotor?
We do not list a known interaction between Galphimia Glauca and Voxelotor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Galphimia Glauca and Voxelotor have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Galphimia Glauca and Voxelotor combination checked?
Interactions in our licensed database are recorded against drug classes. Voxelotor is filed under 3 classifications, and Galphimia Glauca has documented interactions with 1 drug class — none of Voxelotor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Galphimia Glauca interact with any other medications?
Yes. Galphimia Glauca has 248 documented drug interactions in our database — Voxelotor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Voxelotor interact with any supplements?
Yes. Voxelotor has documented interactions with 143 supplements in our database — Galphimia Glauca is not one of them. The Voxelotor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Galphimia Glauca monograph Uses, safety profile, and every drug interaction in one place Voxelotor drug information The full plain-English guide to this medication Voxelotor supplement interactions Every supplement checked against Voxelotor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Voxelotor and Galphimia Glauca?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.