Drug & supplement interaction

Garcinia + Isosorbide Dinitrate

Isosorbide Dinitrate brand names: Isordil, Angitak, Cedocard Retard, Isoket Retard, Isoket.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Garcinia and Isosorbide Dinitrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Garcinia and Isosorbide Dinitrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Isosorbide Dinitrate and Garcinia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Garcinia safety at a glance

Garcinia overall Use caution Generally tolerated short-term, but rare reports of liver injury warrant caution.

Pregnancy Avoid Not enough safety data; avoid use during pregnancy.

Breastfeeding Avoid Not enough safety data; avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Isosorbide Dinitrate and Garcinia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Isosorbide Dinitrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Isosorbide Dinitrate is filed under 3 classifications — nitrates, vasodilators, oral drugs. Garcinia has documented interactions with 4 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and hepatotoxic drugs (moderate) — and none of Isosorbide Dinitrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Garcinia Does Interact With Other Medications

Garcinia has 704 moderate known drug interactions in our database — Isosorbide Dinitrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 704 No known interaction 2,126 (incl. Isosorbide Dinitrate)

Taking anything else?

Check Another of Your Medications Against Garcinia

Covers the 2,830 medications we’ve checked against Garcinia. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Garcinia and Isosorbide Dinitrate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

Heart failure Worth acting on Additional detail
Garcinia
“There is a case report of a 48-year-old female who developed acute necrotizing eosinophilic myocarditis (ANEM) after using a garcinia supplement orally for 2.5 weeks. On admission to hospital, she was hypotensive and had an elevated serum troponin level, progressing to fulminant heart failure, acute kidney failure, and sustained ventricular arrhythmias.”

Garcinia · Natural Medicines adverse-effect record, reported in arrhythmia.
2 sources cited

88160. Allen SF, Godley RW, Evron JM, et al. Acute necrotizing eosinophilic myocarditis in a patient taking Garcinia cambogia extract successfully treated with high-dose corticosteroids. Can J Cardiol 2014;30(12):1732 e13-1732 e15. PubMed

16527. Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82.
Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate. Read the label on DailyMed ›
Confusion Worth acting on Additional detail
Garcinia
“In one case report, a 56-year-old female with pre-existing diabetes, hepatitis C, and hypertension developed diabetic ketoacidosis (DKA) and pancreatitis after taking an unknown amount of garcinia and African mango for one month. Upon admission, she presented with altered mental status, elevated serum glucose and lipase, and high anion gap metabolic acidosis.”

Garcinia · Natural Medicines adverse-effect record, reported in diabetes.
4 sources cited

97341. Bystrak T, Cervera-Hernandez ME, Reddy N, King Z, Bratberg J. Garcinia cambogia, diabetic ketoacidosis, and pancreatitis. R I Med J (2013). 2017 Oct 2;100(10):48-50. NO DOI

105056. Iqbal U, Anwar H, Siddiqui HU, Mehmood A. Acute Pancreatitis Secondary to Use of Appetite Suppressant: Garcinia cambogia. Cureus. 2019;11(5):e4676. PubMed

105058. Grigos A, Benmoussa J, Sandhu J, Chaucer B, Clarke M, SH Patel. Acute pancreatitis secondary to Garcinia cambogia; the unknown cost of herbal supplements. JOP. J Pancreas (Online) 2016; 17(3):316-317.

105071. Sidhu RLS, Labana S, Khehra L. Garcinia cambogia: a link between the "miracle" weight loss pill and acute pancreatitis. Am J Gastroenterol. 2016. 111:S560-S561. DOI
Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate. Read the label on DailyMed ›
Raised blood pressure Worth acting on Additional detail

Garcinia

Recorded for Garcinia in the same Natural Medicines adverse-effect record shown under Heart failure above.

Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate. Read the label on DailyMed ›
Anxiety or restlessness Additional detail
Garcinia
“Orally, garcinia supplements have been linked to several cases of mania. Typically, symptoms develop 1-8 weeks after starting garcinia. In a report of three patients, symptoms included reduced need for sleep, increased activities and spending, delusions of grandiosity, pressured speech, and agitation.”

Garcinia · Natural Medicines adverse-effect record, reported in bipolar disorder.
3 sources cited

95568. Hendrickson BP, Shaikh N, Occhiogrosso M, Penzner JB. Mania Induced by Garcinia cambogia: A Case Series. Prim Care Companion CNS Disord. 2016;18(2).

95574. Narasimha A, Shetty PH, Nanjundaswamy MH, Viswanath B, Bada Math S. Hydroxycut - Dietary supplements for weight loss: Can they induce mania? Aust N Z J Psychiatry. 2013;47(12):1205-6. PubMed

99421. Nguyen DC, Timmer TK, Davison BC, McGrane IR. Possible Garcinia cambogia-induced mania with psychosis: a case report. J Pharm Pract 2019;32(1):99-102. doi: 10.1177/0897190017734728.
Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate. Read the label on DailyMed ›
Stomach upset Additional detail

Garcinia

“Orally, garcinia and its constituent, hydroxycitric acid (HCA), seem to be generally well tolerated in clinical research.

Most Common Adverse Effects:

Orally: Diarrhea, gastrointestinal discomfort, headache, and nausea.

Serious Adverse Effects (Rare):

Orally: Garcinia has been linked with cases of hepatotoxicity and liver failure. There have also been rare cases of mania and pancreatitis.”

Garcinia · Natural Medicines adverse-effect record, reported in cluster headache.

Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate. Read the label on DailyMed ›
Dizziness reported in 6.7% of FDA reports for Isosorbide Dinitrate Additional detail
Garcinia
“In one case, a 35-year-old female presented with ocular pain in both eyes, decreased vision in the left eye, headache, dizziness, and nausea after taking garcinia extract orally for one week. Ophthalmologic testing was consistent with adverse ocular effects, showing myopic shift with anterior chamber shallowing and swelling of retinal nerve fiber and macula.”

Garcinia · Natural Medicines adverse-effect record, reported in cluster headache.
1 source cited

102546. Cho HK, Han YS, Park JM. Ocular complications of Garcinia cambogia extract diet pills: case report. Eur J Ophthalmol 2019:1120672119872364. PubMed
“Orally, garcinia and its active constituent hydroxycitric acid (HCA) may cause headache and dizziness. A 35-year-old female reported ocular complications, headache, dizziness, and nausea after taking garcinia extract, providing more than 500 mg of HCA, three times daily for one week. The patient's neurologic symptoms resolved one day after discontinuing the garcinia extract.”

Garcinia · Natural Medicines adverse-effect record, reported in cluster headache.
2 sources cited

11977. Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed

102546. Cho HK, Han YS, Park JM. Ocular complications of Garcinia cambogia extract diet pills: case report. Eur J Ophthalmol 2019:1120672119872364. PubMed
Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Diarrhea reported in 6.7% of FDA reports for Isosorbide Dinitrate Additional detail
Garcinia
“Orally, garcinia and its active constituent hydroxycitric acid (HCA) have caused mild and infrequent nausea, diarrhea, and other gastrointestinal symptoms.”

Garcinia · Natural Medicines adverse-effect record, reported in diarrhea.
5 sources cited

728. Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. PubMed

11977. Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed

19153. Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180.

88158. Vasques CA, Schneider R, Klein-Júnior LC, et al. Hypolipemic effect of Garcinia Cambogia in obese women. Phytother Res 2014;28(6):887-91.

88159. Marquez F, Babio N, Bullo M, Salas-Salvado J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr 2012;52:585-94.
Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›
Swelling Additional detail

Garcinia

Recorded for Garcinia in the same Natural Medicines adverse-effect record shown under Dizziness above.

Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate. Read the label on DailyMed ›
Stomach pain Additional detail
Garcinia
“Orally, garcinia and its constituent hydroxycitric acid (HCA) might cause liver toxicity. Several cases of acute liver toxicity have been reported in patients taking garcinia supplements. Reported doses of garcinia extract range from 480-1800 mg daily, providing up to 900 mg HCA daily. However, not all experts agree that HCA plays a causal role in the hepatotoxicity associated with garcinia supplements;”

Garcinia · Natural Medicines adverse-effect record, reported in cirrhosis.
6 sources cited

93392. Corey R, Werner KT, Singer A, Moss A, Smith M, Noelting J, Rakela J. Acute liver failure associated with Garcinia cambogia use. Ann Hepatol. 2016 Jan-Feb;15(1):123-6. PubMed

93393. Melendez-Rosado J, Snipelisky D, Matcha G, Stancampiano F. Acute hepatitis induced by pure Garcinia cambogia. J Clin Gastroenterol. 2015 May-Jun;49(5):449-50. PubMed

93394. García-Cortés M, Robles-Díaz M, Ortega-Alonso A, Medina-Caliz I, Andrade RJ. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. Int J Mol Sci. 2016 Apr 9;17(4):537. PubMed

95573. Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW. Dangerous dietary supplements: Garcinia cambogia -associated hepatic failure requiring transplantation. World J Gastroenterol. 2016;22(45):10071-10076.

102544. Yousaf MN, Chaudhary FS, Hodanazari SM, Sittambalam CD. Hepatotoxicity associated with Garcinia cambogia: a case report. World J Hepatol 2019;11(11):735-42.

102545. Mas Ordeig A, Bordón García N. Hepatotoxicity caused by Garcinia cambogia. Gastroenterol Hepatol 2020;43(3):134-5. DOI
Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate. Read the label on DailyMed ›
Nausea reported in 7.1% of FDA reports for Isosorbide Dinitrate Additional detail

Garcinia

Recorded for Garcinia in the same Natural Medicines adverse-effect record shown under Stomach upset above.

Isosorbide Dinitrate

Listed in the ADVERSE REACTIONS section of the FDA label for Isosorbide Dinitrate, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Showing the 10 most notable of 11 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Garcinia but not commonly for Isosorbide Dinitrate: liver problems, blurred vision, pancreatitis and kidney problems.

Effects for Isosorbide Dinitrate come from the ADVERSE REACTIONS section of its FDA label; effects for Garcinia come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 19,814 voluntary FDA FAERS reports for Isosorbide Dinitrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Garcinia or Isosorbide Dinitrate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Garcinia or Isosorbide Dinitrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Which Medications Interact With Nitric Oxide Supplements? Answered by Dr. Brian Staiger, PharmD · August 2026 ›

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Isosorbide Dinitrate

This page covers Garcinia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Isosorbide Dinitrate page lists 22 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Coleus (major), Hawthorn (major) and Beer (moderate).

By severity: 4 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Isosorbide Dinitrate page

“Isosorbide dinitrate (Isordil, Isoket) relaxes blood vessels to prevent and relieve angina, so a supplement that pushes that relaxation further, or works against it, is not a small thing, and this list of 22 warrants genuine care. Four entries rate major: herbs with vasodilating effects of their own, like hawthorn, that can stack on to…”

Reviewed by 2 · Jul 18, 2026

Open the Isosorbide Dinitrate interaction page

One more smart check

Taking Garcinia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,374 real supplement products containing Garcinia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Garcinia. Even though Garcinia itself has no known interaction with Isosorbide Dinitrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Garcinia and Isosorbide Dinitrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Garcinia

Top 25%

#166 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Isosorbide Dinitrate

Steady interest

#1,704 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Garcinia reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Garcinia and Isosorbide Dinitrate records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Garcinia

What is Garcinia?

Weight loss
Appetite suppression
Curbing sugar and carb cravings
Supporting metabolism
Traditional cooking and souring agent

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies showing only small or no meaningful weight effects, and rare reports of liver problems raise safety concerns. Talk to a pharmacist or doctor before trying it, especially if you have liver issues, are pregnant, or are breastfeeding.

Garcinia gummi-gutta · Clusiaceae · Fruit rind (pericarp) · Capsules, tablets, powders, gummies, and liquid extracts (often standardized to a percentage of HCA)

An interaction check asks whether these two react with each other — it does not ask whether Garcinia is a good idea for someone in your situation. Here is what our Garcinia record says about it on its own.

Garcinia: dosing

There is no well-established, proven dose for Garcinia. Products vary widely in their strength and in how much HCA they contain, which makes it hard to compare one product to another.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.

From our Garcinia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Garcinia monograph & all interactions

Medication

About Isosorbide

What Is Isosorbide Used For?

Brand names: Isordil, Angitak, Cedocard Retard, Isoket Retard, Isoket

Isosorbide is used to prevent angina pectoris — chest pain or tightness caused by coronary artery disease. Both isosorbide dinitrate tablets and isosorbide mononitrate tablets (including Monoket and Isordil) are used for this purpose.

Important: none of these oral formulations work fast enough to stop a chest pain episode that has already started. They are taken on a schedule to prevent angina, not to treat it in the moment.

Most-Reported Side Effects for Isosorbide Dinitrate

From FAERS, the FDA’s public side-effect reporting system (19,814 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,696 reports

Nausea 1,406 reports

Fatigue 1,382 reports

Dizziness 1,336 reports

Diarrhea 1,334 reports

See full Isosorbide drug information

Keep checking

Other Drugs & Garcinia

Browse every other medication we’ve checked against Garcinia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

704Moderate

0Minor

2,125No known interaction

704 Moderate 2,125 No interaction

Moderate

704 interactions

Showing 60 of 704 moderate interactions — see all 704 on the Garcinia page.

No interaction 2,125 drugs checked — show the list

We also checked Garcinia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,125 medications checked with no known interaction — see the full Garcinia list.

See the full Garcinia interactions page

See every supplement checked against Isosorbide Dinitrate, ranked by severity

Evidence & sources

Garcinia References

The 44 references that drive our Garcinia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. PubMed
Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed
Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82.
Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180.
Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. PubMed
Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. PubMed
Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A. The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. Metabolism 2004;53(1):66-72. PubMed
Asghar M, Monjok E, Kouamou G, et al. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem 2007;304(1-2):93-99. PubMed
Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol 2005;288(6):G1144-G1149. PubMed
Leonhardt M, Balkan B, Langhans W. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. Nutrition 2004;20(10):911-915. PubMed
Bunchorntavakul, C. and Reddy, K. R. Review article: herbal and dietary supplement hepatotoxicity. Aliment.Pharmacol.Ther 2013;37(1):3-17. PubMed
Vasques CA, Schneider R, Klein-Júnior LC, et al. Hypolipemic effect of Garcinia Cambogia in obese women. Phytother Res 2014;28(6):887-91.
Marquez F, Babio N, Bullo M, Salas-Salvado J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr 2012;52:585-94.
Allen SF, Godley RW, Evron JM, et al. Acute necrotizing eosinophilic myocarditis in a patient taking Garcinia cambogia extract successfully treated with high-dose corticosteroids. Can J Cardiol 2014;30(12):1732 e13-1732 e15. PubMed
Dara L, Hewett J, Lim JK. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol. 2008 Dec 7;14(45):6999-7004. PubMed
Sharma T, Wong L, Tsai N, Wong RD. Hydroxycut(®) (herbal weight loss supplement) induced hepatotoxicity: a case report and review of literature. Hawaii Med J. 2010 Aug;69(8):188-90.
Rashid NN, Grant J. Hydroxycut hepatotoxicity. Med J Aust. 2010 Feb 1;192(3):173-4. PubMed
Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis. 2007 Oct;39(10):953-5. PubMed
Corey R, Werner KT, Singer A, Moss A, Smith M, Noelting J, Rakela J. Acute liver failure associated with Garcinia cambogia use. Ann Hepatol. 2016 Jan-Feb;15(1):123-6. PubMed
Melendez-Rosado J, Snipelisky D, Matcha G, Stancampiano F. Acute hepatitis induced by pure Garcinia cambogia. J Clin Gastroenterol. 2015 May-Jun;49(5):449-50. PubMed
García-Cortés M, Robles-Díaz M, Ortega-Alonso A, Medina-Caliz I, Andrade RJ. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. Int J Mol Sci. 2016 Apr 9;17(4):537. PubMed
Dehoney S, Wellein M. Rhabdomyolysis associated with the nutritional supplement Hydroxycut. Am J Health Syst Pharm. 2009;66(2):142-8. PubMed
Fong TL, Klontz KC, Canas-Coto A, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol. 2010;105(7):1561-6. PubMed
Hendrickson BP, Shaikh N, Occhiogrosso M, Penzner JB. Mania Induced by Garcinia cambogia: A Case Series. Prim Care Companion CNS Disord. 2016;18(2).
Kaswala D, Shah S, Patel N, Raisoni S, Swaminathan S. Hydroxycut-induced Liver Toxicity. Ann Med Health Sci Res. 2014; 4(1):143-5. PubMed
Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol. 2009;15(14):1786-7. PubMed
Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW. Dangerous dietary supplements: Garcinia cambogia -associated hepatic failure requiring transplantation. World J Gastroenterol. 2016;22(45):10071-10076.
Narasimha A, Shetty PH, Nanjundaswamy MH, Viswanath B, Bada Math S. Hydroxycut - Dietary supplements for weight loss: Can they induce mania? Aust N Z J Psychiatry. 2013;47(12):1205-6. PubMed
Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci. 2009;54(2):406-8. PubMed
Stohs SJ, Preuss HG, Ohia SE, et al. No evidence demonstrating hepatotoxicity associated with hydroxycitric acid. World J Gastroenterol. 2009;15(32):4087-9. PubMed
Gavril A, Ribnikar M, Smid L, Luzar B, Stabuc B. Fat burner-induced acute liver injury: case series of four patients. Nutrition. 2018;47:110-114. doi: 10.1016/j.nut.2017.10.002. PubMed
Bystrak T, Cervera-Hernandez ME, Reddy N, King Z, Bratberg J. Garcinia cambogia, diabetic ketoacidosis, and pancreatitis. R I Med J (2013). 2017 Oct 2;100(10):48-50. NO DOI
Smith RJ, Bertilone C, Robertson AG. Fulminant liver failure and transplantation after use of dietary supplements. Med J Aust. 2016;204(1):30-2. PubMed
Nguyen DC, Timmer TK, Davison BC, McGrane IR. Possible Garcinia cambogia-induced mania with psychosis: a case report. J Pharm Pract 2019;32(1):99-102. doi: 10.1177/0897190017734728.
Yousaf MN, Chaudhary FS, Hodanazari SM, Sittambalam CD. Hepatotoxicity associated with Garcinia cambogia: a case report. World J Hepatol 2019;11(11):735-42.
Mas Ordeig A, Bordón García N. Hepatotoxicity caused by Garcinia cambogia. Gastroenterol Hepatol 2020;43(3):134-5. DOI
Cho HK, Han YS, Park JM. Ocular complications of Garcinia cambogia extract diet pills: case report. Eur J Ophthalmol 2019:1120672119872364. PubMed
Ferreira V, Mathieu A, Soucy G, Giard JM, Erard-Poinsot D. Acute severe liver injury related to long-term Garcinia cambogia intake. ACG Case Rep J. 2020;7(8):e00429. PubMed
Iqbal U, Anwar H, Siddiqui HU, Mehmood A. Acute Pancreatitis Secondary to Use of Appetite Suppressant: Garcinia cambogia. Cureus. 2019;11(5):e4676. PubMed
Grigos A, Benmoussa J, Sandhu J, Chaucer B, Clarke M, SH Patel. Acute pancreatitis secondary to Garcinia cambogia; the unknown cost of herbal supplements. JOP. J Pancreas (Online) 2016; 17(3):316-317.
Sidhu RLS, Labana S, Khehra L. Garcinia cambogia: a link between the "miracle" weight loss pill and acute pancreatitis. Am J Gastroenterol. 2016. 111:S560-S561. DOI
Vuppalanchi R, Bonkovsky HL, Ahmad J, et al. Garcinia cambogia, Either Alone or in Combination With Green Tea, Causes Moderate to Severe Liver Injury. Clin Gastroenterol Hepatol 2021. PubMed
Calaquian LL, Yau I. Garcinia cambogia-A Supplement-Related Liver Injury. Cureus 2022;14(2):e22225. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Garcinia and Isosorbide Dinitrate Together: Common Questions

Is it safe to take Garcinia with Isosorbide Dinitrate?

We do not list a known interaction between Garcinia and Isosorbide Dinitrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Garcinia and Isosorbide Dinitrate have any of the same side effects?

Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Garcinia and Isosorbide Dinitrate combination checked?

Interactions in our licensed database are recorded against drug classes. Isosorbide Dinitrate is filed under 3 classifications, and Garcinia has documented interactions with 4 drug classes — none of Isosorbide Dinitrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Garcinia interact with any other medications?

Yes. Garcinia has 704 documented drug interactions in our database — Isosorbide Dinitrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Isosorbide Dinitrate interact with any supplements?

Yes. Isosorbide Dinitrate has documented interactions with 22 supplements in our database — Garcinia is not one of them. The Isosorbide Dinitrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Garcinia monograph Uses, safety profile, and every drug interaction in one place Isosorbide drug information The full plain-English guide to this medication Isosorbide Dinitrate supplement interactions Every supplement checked against Isosorbide Dinitrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 44 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.