Drug & supplement interaction

Garden Cress + Methyclothiazide, Reserpine

Methyclothiazide, Reserpine brand name: Diutensen-R.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Methyclothiazide, Reserpine falls into 2 drug categories that Garden Cress can interact with; the most serious is rated moderate. Theoretically, taking garden cress with antihypertensive drugs might increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Garden Cress and Methyclothiazide, Reserpine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Garden Cress interacts with whole categories of medication. Methyclothiazide, Reserpine falls into 2 of those categories, so it can interact with Garden Cress in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 2

Why this applies to Methyclothiazide, Reserpine

Methyclothiazide, Reserpine falls under ANTIHYPERTENSIVE DRUGS — the group Garden Cress interacts with.

Theoretically, taking garden cress with antihypertensive drugs might increase the risk of hypotension.
Garden cress has shown hypotensive effects in animal research and increases levels and effects of the antihypertensive medications amlodipine and losartan. This has not been shown in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Diutensen-R combines two blood pressure lowering ingredients: methyclothiazide, a water pill, and reserpine, which relaxes blood vessels. Garden cress has shown its own mild blood pressure lowering effect in animal studies, so the concern here is simple addition. If the cress nudges your pressure down while these medicines are already doing the same job, your numbers could dip a little lower than expected.

If that happens, you might feel dizzy, lightheaded, tired, or unsteady when you stand up quickly. I want to be honest though: this is theoretical and based only on animal research, not people. Normal food amounts of cress are very unlikely to matter. Concentrated seed supplements are where I'd be a bit more careful. Check with your pharmacist or doctor before starting one.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Maghrani, M, Zeggwagh, NA, Michel, JB, and Eddouks, M. Antihypertensive effect of <it>Lepidium sativum</it> L. in spontaneously hypertensive rats. Journal of Ethnopharmacology (Ireland) 2005;100:193-197.
  2. Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
  3. Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FI. Herb-drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa. Xenobiotica 2022;52(2):177
  4. Ahad A, Raish M, Abdelrahman IA, et al. Changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with Curcuma longa and Lepidium sativum. Pharmaceuticals (Basel) 2022;16(1):33. PubMed
Moderate

DIURETIC DRUGS

2 of 2

Methyclothiazide, Reserpine also falls under DIURETIC DRUGS.

Theoretically, taking garden cress with diuretic drugs might increase the risk of hypokalemia.
Evidence from animal research suggests that garden cress has diuretic effects and can increase the urinary excretion of potassium. This has not been shown in humans. Initiation of potassium supplementation or an increase in potassium supplement dose may be necessary for some patients.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Diutensen-R, which pairs methyclothiazide (a water pill) with reserpine. That thiazide already nudges your body to flush out potassium in the urine. Garden cress, at least in animal studies, seems to act like a mild diuretic too and may push out a little extra potassium. Stack the two and the worry is your potassium could dip lower than it should, what we call hypokalemia.

Low potassium can leave you feeling tired, crampy, weak, or give you an irregular heartbeat. To be honest, this is only theoretical right now and hasn't been proven in people, and a sprinkle of cress in your cooking is unlikely to matter. Concentrated seed supplements are a different story. Before adding those, check with your pharmacist or doctor so they can keep an eye on your potassium.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Maghrani, M, Zeggwagh, NA, Michel, JB, and Eddouks, M. Antihypertensive effect of <it>Lepidium sativum</it> L. in spontaneously hypertensive rats. Journal of Ethnopharmacology (Ireland) 2005;100:193-197.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Garden Cress Also Interacts With Other Medications

Garden Cress has 397 moderate known drug interactions in our database — the Methyclothiazide, Reserpine one above is among them. If you take anything else, check it against the full list below.

Moderate 397 No known interaction 2,433 (incl. Methyclothiazide, Reserpine)
Taking anything else?

Check Another of Your Medications Against Garden Cress

Covers the 2,830 medications we’ve checked against Garden Cress. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Methyclothiazide, Reserpine

This page covers Garden Cress only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methyclothiazide, Reserpine page lists 228 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 193 moderate · 25 minor.

From our pharmacist’s overview on the Methyclothiazide, Reserpine page

“Diutensen-R pairs methyclothiazide, a thiazide diuretic, with reserpine, and both halves work to pull blood pressure down, which is why the 228 supplement and herbal interactions on file here deserve genuine vigilance. Most entries either push blood pressure lower than intended or deepen the diuretic effect, draining more fluid and pot…”

Reviewed by 2 · Jul 18, 2026

Open the Methyclothiazide, Reserpine interaction page

One more smart check

Taking Garden Cress as Part of a Dietary Supplement Product? Check It for Interactions

We hold 16 real supplement products containing Garden Cress, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Garden Cress. Your product may carry other ingredients that interact with Methyclothiazide, Reserpine too, on top of Garden Cress — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Garden Cress and Methyclothiazide, Reserpine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Garden Cress
Steady interest

#966 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methyclothiazide, Reserpine
Steady interest

#2,671 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Garden Cress

What is Garden Cress?

Garden Cress
  • Digestive support
  • Bone health
  • Iron and vitamin source
  • Cough and respiratory comfort
  • Boosting breast milk (traditional)
  • Constipation relief

Garden cress is a nutritious leafy herb and seed used widely in cooking and traditional medicine, providing vitamins, minerals, and fiber. While it has a long history of use for digestion, bone health, and lactation, strong human research supporting most medicinal claims is limited. It is generally safe as a food, but concentrated seed supplements should be used cautiously and avoided in pregnancy.

Read the full Garden Cress monograph & all interactions
Keep checking

Other Drugs & Garden Cress

Browse every other medication we’ve checked against Garden Cress — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
397Moderate
0Minor
2,432No known interaction
397 Moderate 2,432 No interaction
Moderate

397 interactions

Showing 60 of 397 moderate interactions — see all 397 on the Garden Cress page.

No interaction 2,432 drugs checked — show the list

We also checked Garden Cress against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,432 medications checked with no known interaction — see the full Garden Cress list.

See the full Garden Cress interactions page
See every supplement checked against Methyclothiazide, Reserpine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Garden Cress monograph › Uses, safety, and every drug interaction in one place Methyclothiazide, Reserpine supplement interactions › Every supplement checked against Methyclothiazide, Reserpine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Garden Cress and Methyclothiazide, Reserpine Together: Common Questions

Can you take Garden Cress with Methyclothiazide, Reserpine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Garden Cress and Methyclothiazide, Reserpine?
Methyclothiazide, Reserpine belongs to more than one drug category, and Garden Cress interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Garden Cress and Methyclothiazide, Reserpine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.