Drug & supplement interaction

Garden Cress + Tapentadol

Tapentadol brand names: Nucynta, Nucynta ER.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Garden Cress and Tapentadol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Garden Cress and Tapentadol

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tapentadol and Garden Cress in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Garden Cress safety at a glance

Garden Cress overall Use caution Generally safe as a food, but concentrated seed amounts have limited safety data.
Pregnancy Avoid Seeds are traditionally believed to stimulate the uterus, so avoid medicinal amounts during pregnancy.
Breastfeeding Use caution Food amounts are likely fine, but safety of concentrated supplements is not well studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tapentadol and Garden Cress? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tapentadol

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tapentadol is filed under 6 classifications — including cytochrome p450 2c19 (cyp2c19) substrates, cytochrome p450 2c9 (cyp2c9) substrates, serotonergic drugs. Garden Cress has documented interactions with 14 drug classes — the most serious being amlodipine (norvasc) (moderate), anticoagulant/antiplatelet drugs (moderate) and antidiabetes drugs (moderate) — and none of Tapentadol’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Garden Cress Does Interact With Other Medications

Garden Cress has 398 moderate known drug interactions in our database — Tapentadol isn’t one of them. If you take anything else, check it against the full list below.

Moderate 398 No known interaction 2,432 (incl. Tapentadol)
Taking anything else?

Check Another of Your Medications Against Garden Cress

Covers the 2,830 medications we’ve checked against Garden Cress. Pick one to open its full report.

What to actually watch for

What Tapentadol’s Own FDA Label Lists

This is not an interaction — none of it involves Garden Cress. These are the most notable effects listed in the ADVERSE REACTIONS section of Tapentadol’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • Serotonin syndrome Worth acting on
  • Seizures Worth acting on
  • Back pain
  • Low blood pressure
  • Drowsiness
  • Constipation
  • Dizziness
  • Headache
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Tapentadol. Read the label on DailyMed › Garden Cress’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Garden Cress side to compare — that is a limit of the record, not a statement that Garden Cress has no side effects.

Overlapping uses

What Tapentadol Is Prescribed For, and What Garden Cress Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Tapentadol is a prescription medicine with approved uses on its FDA label. Garden Cress is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Tapentadol is prescribed for: Tapentadol tablets (including Nucynta and Tapentadol Hydrochloride tablets) are used for severe acute pain in adults when other treatments are not adequate. Nucynta tablets are also approved for acute pain in children aged 6 and older who weigh at least 40 kg. Nucynta ER and tapentadol extended-release tablets are used for severe, ongoing pain that requires around-the-clock opioid treatment and cannot be managed with other options, including severe neuropathic pain (nerve pain) caused by diabetic peripheral neuropathy in adults. Extended-release formulations are not intended for as-needed use.

Garden Cress has been studied for:

  • Diabetes studied, not established Garden Cress has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Garden Cress for diabetes

    Although there has been interest in using oral garden cress for diabetes, there is insufficient reliable information about the clinical effects of garden cress for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tapentadol on your own; if you are taking Garden Cress for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Garden Cress or Tapentadol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Garden Cress or Tapentadol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tapentadol

This page covers Garden Cress only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tapentadol page lists 113 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Adrafinil (moderate).

By severity: 2 major · 84 moderate · 27 minor.

From our pharmacist’s overview on the Tapentadol page

“Tapentadol (Nucynta, Nucynta ER) is an opioid painkiller that also boosts serotonin signaling on its own, and that is exactly where its supplement list bites hardest. The two major-rated entries among the 113 on file deserve a hard look first: lithium, which alongside a serotonergic drug like tapentadol can raise the risk of serotonin…”

Reviewed by 2 · Jul 18, 2026

Open the Tapentadol interaction page

One more smart check

Taking Garden Cress as Part of a Dietary Supplement Product? Check It for Interactions

We hold 16 real supplement products containing Garden Cress, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Garden Cress. Even though Garden Cress itself has no known interaction with Tapentadol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Garden Cress and Tapentadol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Garden Cress
Steady interest

#1,195 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tapentadol
Steady interest

#2,156 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Garden Cress reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Garden Cress and Tapentadol records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Garden Cress

What is Garden Cress?

Garden Cress
  • Digestive support
  • Bone health
  • Iron and vitamin source
  • Cough and respiratory comfort
  • Boosting breast milk (traditional)
  • Constipation relief

Garden cress is a nutritious leafy herb and seed used widely in cooking and traditional medicine, providing vitamins, minerals, and fiber. While it has a long history of use for digestion, bone health, and lactation, strong human research supporting most medicinal claims is limited. It is generally safe as a food, but concentrated seed supplements should be used cautiously and avoided in pregnancy.

Lepidium sativum · Brassicaceae · Seeds and leaves · Fresh leaves, seeds, seed powder, sprouts

An interaction check asks whether these two react with each other — it does not ask whether Garden Cress is a good idea for someone in your situation. Here is what our Garden Cress record says about it on its own.

Garden Cress: dosing

There is no official, standardized medicinal dose for garden cress. It is most often consumed as a food—fresh leaves, sprouts, or soaked seeds added to meals or drinks.If you use a seed powder or supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Garden Cress monograph — the full record covers uses, side effects and every documented interaction.

Read the full Garden Cress monograph & all interactions
Medication

About Tapentadol

What Is Tapentadol Used For?

Brand names: Nucynta, Nucynta ER

Tapentadol tablets (including Nucynta and Tapentadol Hydrochloride tablets) are used for severe acute pain in adults when other treatments are not adequate. Nucynta tablets are also approved for acute pain in children aged 6 and older who weigh at least 40 kg.

Nucynta ER and tapentadol extended-release tablets are used for severe, ongoing pain that requires around-the-clock opioid treatment and cannot be managed with other options, including severe neuropathic pain (nerve pain) caused by diabetic peripheral neuropathy in adults. Extended-release formulations are not intended for as-needed use.

See full Tapentadol drug information
Keep checking

Other Drugs & Garden Cress

Browse every other medication we’ve checked against Garden Cress — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
398Moderate
0Minor
2,431No known interaction
398 Moderate 2,431 No interaction
Moderate

398 interactions

Showing 60 of 398 moderate interactions — see all 398 on the Garden Cress page.

No interaction 2,431 drugs checked — show the list

We also checked Garden Cress against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,431 medications checked with no known interaction — see the full Garden Cress list.

See the full Garden Cress interactions page
See every supplement checked against Tapentadol, ranked by severity
Evidence & sources

Garden Cress References

The 12 references that drive our Garden Cress monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Eddouks, M. and Maghrani, M. Effect of Lepidium sativum L. on renal glucose reabsorption and urinary TGF-beta 1 levels in diabetic rats. Phytother.Res 2008;22(1):1-5.
  2. Maghrani, M, Zeggwagh, NA, Michel, JB, and Eddouks, M. Antihypertensive effect of <it>Lepidium sativum</it> L. in spontaneously hypertensive rats. Journal of Ethnopharmacology (Ireland) 2005;100:193-197.
  3. Al-Jenoobi FI, Ahad A, Mahrous GM, Al-Mohizea AM, AlKharfy KM, Al-Suwayeh SA. Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs. Pharm Biol 2015;53(2):296-300. PubMed
  4. Alkharfy KM, Al-Jenoobi FI, Alam MA, et al. Lepidium sativum but not Nigella sativa affects carbamazepine disposition in an animal model. Drug Metab Lett 2013;7:47-51. PubMed
  5. Chen X, Yuan H, Shi F, Zhu Y. Effect of garden cress in reducing blood glucose, improving blood lipids, and reducing oxidative stress in a mouse model of diabetes induced by a high-fat diet and streptozotocin. J Sci Food Agric 2020;100(5):2074-2081. PubMed
  6. Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
  7. Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
  8. Ramadan S, Hegab AM, Al-Awthan YS, Al-Duais MA, Tayel AA, Al-Saman MA. Comparison of the efficiency of Lepidium sativum, Ficus carica, and Punica granatum methanolic extracts in relieving hyperglycemia and hyperlipidemia of streptozotocin-induced diabetic
  9. I Al-Suwaydani A, Alam MA, Raish M, A Bin Jardan Y, Ahad A, I Al-Jenoobi F. Effect of C. cyminum and L. sativum on pharmacokinetics and pharmacodynamics of antidiabetic drug gliclazide. Curr Drug Metab 2022;23(10):842-849.
  10. Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FI. Herb-drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa. Xenobiotica 2022;52(2):177
  11. Ahad A, Raish M, Abdelrahman IA, et al. Changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with Curcuma longa and Lepidium sativum. Pharmaceuticals (Basel) 2022;16(1):33. PubMed
  12. Doghmane A, Aouacheri O, Laouaichia R, Saka S. The investigation of the efficacy ratio of cress seeds supplementation to moderate hyperglycemia and hepatotoxicity in streptozotocin-induced diabetic rats. J Diabetes Metab Disord 2021;20(1):447-459. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Garden Cress and Tapentadol Together: Common Questions

Is it safe to take Garden Cress with Tapentadol?
We do not list a known interaction between Garden Cress and Tapentadol. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Garden Cress and Tapentadol used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Garden Cress in each. That is a conversation for your prescriber, especially if Tapentadol is being adjusted to a target.
How was the Garden Cress and Tapentadol combination checked?
Interactions in our licensed database are recorded against drug classes. Tapentadol is filed under 6 classifications, and Garden Cress has documented interactions with 14 drug classes — none of Tapentadol's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Garden Cress interact with any other medications?
Yes. Garden Cress has 398 documented drug interactions in our database — Tapentadol is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tapentadol interact with any supplements?
Yes. Tapentadol has documented interactions with 113 supplements in our database — Garden Cress is not one of them. The Tapentadol interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Garden Cress monograph Uses, safety profile, and every drug interaction in one place Tapentadol drug information The full plain-English guide to this medication Tapentadol supplement interactions Every supplement checked against Tapentadol, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tapentadol and Garden Cress?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.