Drug & supplement interaction

Golden Ragwort + Alpelisib

Alpelisib brand name: Piqray.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Golden Ragwort and Alpelisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Alpelisib states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Golden Ragwort and Alpelisib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alpelisib and Golden Ragwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Golden Ragwort safety at a glance

Golden Ragwort overall Avoid It contains pyrrolizidine alkaloids that can be toxic to the liver.
Pregnancy Likely Unsafe When used orally. Golden ragwort preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is ins... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in golden ragwort are excreted in breast-milk. There is insufficient reliable information... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alpelisib and Golden Ragwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Alpelisib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Alpelisib is filed under 3 classifications — cytochrome p450 2c9 (cyp2c9) inducers, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Golden Ragwort has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Alpelisib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Golden Ragwort Does Interact With Other Medications

Golden Ragwort has 87 moderate known drug interactions in our database — Alpelisib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Alpelisib)
Taking anything else?

Check Another of Your Medications Against Golden Ragwort

Covers the 2,830 medications we’ve checked against Golden Ragwort. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Golden Ragwort and Alpelisib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea / Vomiting Additional detail

    Golden Ragwort

    “Orally, the major concern with golden ragwort use is its pyrrolizidine alkaloid (PA) content. These constituents can cause liver injury. Chronic exposure to other plants containing hepatotoxic PA constituents is associated with veno-occlusive disease. Subacute veno-occlusive disease can cause vague symptoms, including colicky pains, vomiting, diarrhea, and ascites within several days;”

    Golden Ragwort · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    3. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.

    Alpelisib

    Listed in the ADVERSE REACTIONS section of the FDA label for Alpelisib. Read the label on DailyMed ›

Reported for Golden Ragwort but not commonly for Alpelisib: raised blood pressure and liver problems.

Effects for Alpelisib come from the ADVERSE REACTIONS section of its FDA label; effects for Golden Ragwort come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Golden Ragwort in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Golden ragwort preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of using golden ragwort products that do not contain hepatotoxic PAs during pregnancy.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in golden ragwort are excreted in breast-milk. There is insufficient reliable information available about the safety of using golden ragwort products that are PA-free during lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Alpelisib Products Have a Food Rule — Golden Ragwort Should Not Break It

At least one FDA label for a product containing Alpelisib says to take it with food. If you take Golden Ragwort on an empty stomach out of habit, keep them separate — and take Alpelisib with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Alpelisib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended Dose: Pediatric patients (2 to less than 18 years of age): 50 mg taken orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Alpelisib — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Alpelisib

This page covers Golden Ragwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alpelisib page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 40 minor.

From our pharmacist’s overview on the Alpelisib page

“Alpelisib (Piqray) treats PIK3CA-mutated breast cancer, and a drug doing that job leaves little room for supplements that shift its blood level. Yet that is what most of this list does: 121 of the 139 ingredients on file can raise or lower alpelisib through CYP3A4, the liver enzyme that clears it.”

Reviewed by 2 · Jul 18, 2026

Open the Alpelisib interaction page

One more smart check

Taking Golden Ragwort as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Golden Ragwort, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Golden Ragwort. Even though Golden Ragwort itself has no known interaction with Alpelisib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Golden Ragwort and Alpelisib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Golden Ragwort
Top half

#541 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alpelisib
Steady interest

#1,806 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Golden Ragwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Golden Ragwort and Alpelisib records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Golden Ragwort

What is Golden Ragwort?

  • Menstrual complaints
  • Easing childbirth (traditional)
  • Urinary discomfort
  • Sore throat (folk use)

Golden Ragwort is a flowering plant once used in traditional and folk medicine, mainly for menstrual and female reproductive complaints. It contains pyrrolizidine alkaloids that can cause serious liver damage, so it is not considered safe for internal use, and modern herbalists generally avoid it.

Packera aurea · Asteraceae · Aerial parts (leaves, stems, flowers) and roots · Tea, tincture, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Golden Ragwort is a good idea for someone in your situation. Here is what our Golden Ragwort record says about it on its own.

Golden Ragwort: dosing

There is no established safe dose for Golden Ragwort, and no standardized products are recommended. Because it contains liver-toxic pyrrolizidine alkaloids, health authorities generally advise against taking it at all.If you come across a product that contains this plant, do not assume any amount is safe.

From our Golden Ragwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Golden Ragwort monograph & all interactions
Medication

About Alpelisib

What Is Alpelisib Used For?

Brand name: Piqray

Alpelisib is approved for two distinct uses, each tied to a specific brand. Piqray is used in combination with another drug called fulvestrant to treat adults with hormone receptor (HR)-positive, HER2-negative, advanced or metastatic breast cancer whose tumors carry a PIK3CA mutation — and only after the cancer has progressed on or after a hormone-based treatment. A companion diagnostic test is required before starting Piqray.

Vijoice is used to treat adults and children 2 years of age and older who have severe manifestations of PIK3CA-Related Overgrowth Spectrum (PROS) — a rare condition where PIK3CA gene mutations cause abnormal tissue, vascular, and bone overgrowth — and who need systemic (whole-body) therapy. Vijoice's approval for PROS was granted under the FDA's accelerated approval pathway based on response data, and continued approval may depend on confirmatory trials.

See full Alpelisib drug information
Keep checking

Other Drugs & Golden Ragwort

Browse every other medication we’ve checked against Golden Ragwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Golden Ragwort page.

No interaction 2,742 drugs checked — show the list

We also checked Golden Ragwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Golden Ragwort list.

See the full Golden Ragwort interactions page
See every supplement checked against Alpelisib, ranked by severity
Evidence & sources

Golden Ragwort References

The 4 references that drive our Golden Ragwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Golden Ragwort and Alpelisib Together: Common Questions

Is it safe to take Golden Ragwort with Alpelisib?
We do not list a known interaction between Golden Ragwort and Alpelisib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Golden Ragwort and Alpelisib have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Golden Ragwort and Alpelisib at the same time of day?
At least one FDA label for a product containing Alpelisib says to take it with food. If you take Golden Ragwort on an empty stomach out of habit, keep them separate and take Alpelisib with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Alpelisib products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Golden Ragwort and Alpelisib combination checked?
Interactions in our licensed database are recorded against drug classes. Alpelisib is filed under 3 classifications, and Golden Ragwort has documented interactions with 1 drug class — none of Alpelisib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Golden Ragwort interact with any other medications?
Yes. Golden Ragwort has 87 documented drug interactions in our database — Alpelisib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Alpelisib interact with any supplements?
Yes. Alpelisib has documented interactions with 139 supplements in our database — Golden Ragwort is not one of them. The Alpelisib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Golden Ragwort monograph Uses, safety profile, and every drug interaction in one place Alpelisib drug information The full plain-English guide to this medication Alpelisib supplement interactions Every supplement checked against Alpelisib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alpelisib and Golden Ragwort?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.