Drug & supplement interaction

Gotu Kola + Mirtazapine

Mirtazapine brand name: Remeron.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Gotu Kola and Mirtazapine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Gotu Kola and Mirtazapine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mirtazapine and Gotu Kola in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gotu Kola safety at a glance

Gotu Kola overall Use caution Generally considered well tolerated short-term, but quality evidence is limited and liver concerns have been reported.
Pregnancy Possibly Safe When used topically and appropriately. There is insufficient reliable information available about the safety gotu kola when used orally during pregnancy; avoid... Read the full pregnancy detail
Breastfeeding Avoid Safety during breastfeeding is unknown, so it is best avoided.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mirtazapine and Gotu Kola? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mirtazapine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mirtazapine is filed under 9 classifications — including antidepressant drugs, serotonergic drugs, serotonergic drugs. Gotu Kola has documented interactions with 2 drug classes — the most serious being cns depressants (moderate) and hepatotoxic drugs (moderate) — and none of Mirtazapine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gotu Kola Does Interact With Other Medications

Gotu Kola has 579 moderate known drug interactions in our database — Mirtazapine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 579 No known interaction 2,251 (incl. Mirtazapine)
Taking anything else?

Check Another of Your Medications Against Gotu Kola

Covers the 2,830 medications we’ve checked against Gotu Kola. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Gotu Kola and Mirtazapine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Acne / Stomach pain / Vomiting Additional detail

    Gotu Kola

    “There is concern that gotu kola may cause liver toxicity in some patients. There are at least four case reports of hepatotoxicity associated with gotu kola; however, hepatotoxic contaminants cannot be ruled out, as laboratory analysis was not conducted on the products used. Additionally, the doses of gotu kola used in these cases were not reported.”

    Gotu Kola · Natural Medicines adverse-effect record, reported in acne.

    3 sources cited
    1. 13182. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
    2. 92506. Dantuluri S, North-lewis P, Karthik SV. Gotu Kola induced hepatotoxicity in a child - need for caution with alternative remedies. Dig Liver Dis. 2011;43(6):500. PubMed
    3. 11065. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI

    Mirtazapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mirtazapine. Read the label on DailyMed ›

  • Stomach upset / Nausea Additional detail

    Gotu Kola

    “In some patients, gotu kola can extract cause gastrointestinal upset and nausea.”

    Gotu Kola · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 780. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
    2. 6887. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
    3. 52894. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.

    Mirtazapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mirtazapine. Read the label on DailyMed ›

  • Itching / A skin rash Additional detail

    Gotu Kola

    “Topically, gotu kola can cause allergic contact dermatitis, characterized by erythema, itching, papules, and a burning sensation (4,6887,9789,52875,52887,52896,52902). One specific gotu kola product (Blasteostimulina, Almirall, S. A.) has been reported to cause allergic contact dermatitis in some patients. However, not all patients who react to this product are sensitive to gotu kola;”

    Gotu Kola · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    2. 6887. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
    3. 9789. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
    4. 52875. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
    5. 52887. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
    6. 52896. Danese, P., Carnevali, C., and Bertazzoni, M. G. Allergic contact dermatitis due to Centella asiatica extract. Contact Dermatitis 1994;31(3):201.

    “Topically, gotu kola may cause eczema. Also, gotu kola can cause allergic contact dermatitis, characterized by erythema, itching, papules, and a burning sensation (4,6887,9789,52875,52887,52896,52902). One specific gotu kola product (Blasteostimulina,Almirall, S. A.) has been reported to cause allergic contact dermatitis. However, not all patients with reactions to this product are sensitive to gotu kola;”

    Gotu Kola · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 10277. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
    2. 10278. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
    3. 4. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
    4. 6887. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
    5. 9789. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
    6. 52875. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.

    Mirtazapine

    Listed in the ADVERSE REACTIONS section of the FDA label for Mirtazapine. Read the label on DailyMed ›

Reported for Gotu Kola but not commonly for Mirtazapine: liver problems.

Effects for Mirtazapine come from the ADVERSE REACTIONS section of its FDA label; effects for Gotu Kola come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Gotu Kola in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used topically and appropriately. There is insufficient reliable information available about the safety gotu kola when used orally during pregnancy; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Mirtazapine Is Prescribed For, and What Gotu Kola Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Mirtazapine is a prescription medicine with approved uses on its FDA label. Gotu Kola is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Mirtazapine is prescribed for: Mirtazapine tablets, mirtazapine orally disintegrating tablets, Remeron, and RemeronsолTab are all indicated for the treatment of major depressive disorder (MDD) in adults. Major depressive disorder involves a persistently low or sad mood most days, often accompanied by loss of interest, sleep changes, fatigue, and difficulty concentrating. The effectiveness of mirtazapine tablets in maintaining a response for up to 40 weeks after an initial treatment period has also been demonstrated. Patients should be reassessed periodically to determine whether continued treatment is needed.

Gotu Kola has been studied for:

  • Depression studied, not established Gotu Kola has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Gotu Kola for depression

    Although there is interest in using oral gotu kola for depression, there is insufficient reliable information about the clinical effects of gotu kola for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Mirtazapine on your own; if you are taking Gotu Kola for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Gotu Kola or Mirtazapine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Gotu Kola or Mirtazapine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Mirtazapine

This page covers Gotu Kola only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mirtazapine page lists 212 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 1,3-dmaa (moderate).

By severity: 4 major · 162 moderate · 46 minor.

From our pharmacist’s overview on the Mirtazapine page

“Depression and poor sleep tend to travel together, which is why people on mirtazapine (Remeron) so often eye herbal mood and sleep remedies, and that overlap is exactly where this list demands real care. Four of the 212 ingredients on file carry a major rating.”

Reviewed by 2 · Jul 18, 2026

Open the Mirtazapine interaction page

One more smart check

Taking Gotu Kola as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,832 real supplement products containing Gotu Kola, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gotu Kola. Even though Gotu Kola itself has no known interaction with Mirtazapine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gotu Kola and Mirtazapine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gotu Kola
Top 25%

#150 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mirtazapine
Top 25%

#308 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gotu Kola reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Gotu Kola and Mirtazapine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gotu Kola

What is Gotu Kola?

Gotu Kola
  • Wound healing
  • Varicose veins and poor circulation
  • Anxiety and stress
  • Memory and mental clarity
  • Skin health and scarring

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest possible benefits for vein health and skin, but the overall evidence is limited and not strong. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have liver problems.

Centella asiatica · Apiaceae · Leaves and stems (aerial parts) · Tea, capsules, tablets, tinctures, dried herb, topical creams and ointments

An interaction check asks whether these two react with each other — it does not ask whether Gotu Kola is a good idea for someone in your situation. Here is what our Gotu Kola record says about it on its own.

Gotu Kola: dosing

There is no single official or proven dose for gotu kola. The amount used in studies has varied widely depending on the product, the extract used, and the condition being studied.Because products differ a lot in strength and form (tea, capsule, tincture, cream), the best approach is to follow the directions on the product label. Do not use more than the label recommends.

From our Gotu Kola monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gotu Kola monograph & all interactions
Medication

About Mirtazapine

What Is Mirtazapine Used For?

Brand name: Remeron

Mirtazapine tablets, mirtazapine orally disintegrating tablets, Remeron, and RemeronsолTab are all indicated for the treatment of major depressive disorder (MDD) in adults. Major depressive disorder involves a persistently low or sad mood most days, often accompanied by loss of interest, sleep changes, fatigue, and difficulty concentrating.

The effectiveness of mirtazapine tablets in maintaining a response for up to 40 weeks after an initial treatment period has also been demonstrated. Patients should be reassessed periodically to determine whether continued treatment is needed.

See full Mirtazapine drug information
Keep checking

Other Drugs & Gotu Kola

Browse every other medication we’ve checked against Gotu Kola — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
579Moderate
0Minor
2,250No known interaction
579 Moderate 2,250 No interaction
Moderate

579 interactions

Showing 60 of 579 moderate interactions — see all 579 on the Gotu Kola page.

No interaction 2,250 drugs checked — show the list

We also checked Gotu Kola against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,250 medications checked with no known interaction — see the full Gotu Kola list.

See the full Gotu Kola interactions page
See every supplement checked against Mirtazapine, ranked by severity
Evidence & sources

Gotu Kola References

The 18 references that drive our Gotu Kola monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiol 1987;38:46-50. PubMed
  3. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  4. Eun HC, Lee AY. Contact dermatitis due to madecassol. Contact Dermatitis 1985;13:310-3.. PubMed
  5. Hausen BM. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Contact Dermatitis 1993;29:175-9..
  6. Bilbao I, Aguirre A, Zabala R, et al. Allergic contact dermatitis from butoxyethyl nicotinic acid and Centella asiatica extract. Contact Dermatitis 1995;33:435-6.
  7. Cesarone MR, Incandela L, De Sanctis MT, et al. Evaluation of treatment of diabetic microangiopathy with total triterpenic fraction of Centella asiatica: a clinical prospective randomized trial with a microcirculatory model. Angiology 2001;52 Suppl 2 DOI
  8. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed
  9. Young GL, Jewell D. Creams for preventing stretch marks in pregnancy. Cochrane Database Syst Rev 2000;(2):CD000066. PubMed
  10. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005;97:115-24. PubMed
  11. Mallol J, Belda MA, Costa D, et al. Prophylaxis of striae gravidarum with a topical formulation. A double blind trial. Int J Cosmet Sci 1991;3:51-7.
  12. Izu, R., Aguirre, A., Gil, N., and Diaz-Perez, J. L. Allergic contact dermatitis from a cream containing Centella asiatica extract. Contact Dermatitis 1992;26(3):192-193.
  13. Santucci, B., Picardo, M., and Cristaudo, A. Contact dermatitis due to Centelase. Contact Dermatitis 1985;13(1):39. PubMed
  14. Vena, G. A. and Angelini, G. Contact allergy to Centelase. Contact Dermatitis 1986;15(2):108-109. PubMed
  15. Marastoni, F., Baldo, A., Redaelli, G., and Ghiringhelli, L. [Centella asiatica extract in venous pathology of the lower limbs and its evaluation as compared with tribenoside]. Minerva Cardioangiol. 1982;30(4):201-207.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gotu Kola and Mirtazapine Together: Common Questions

Is it safe to take Gotu Kola with Mirtazapine?
We do not list a known interaction between Gotu Kola and Mirtazapine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Gotu Kola and Mirtazapine have any of the same side effects?
Yes — our sources link each of them separately to 7 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Gotu Kola and Mirtazapine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Gotu Kola in each. That is a conversation for your prescriber, especially if Mirtazapine is being adjusted to a target.
How was the Gotu Kola and Mirtazapine combination checked?
Interactions in our licensed database are recorded against drug classes. Mirtazapine is filed under 9 classifications, and Gotu Kola has documented interactions with 2 drug classes — none of Mirtazapine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Gotu Kola interact with any other medications?
Yes. Gotu Kola has 579 documented drug interactions in our database — Mirtazapine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mirtazapine interact with any supplements?
Yes. Mirtazapine has documented interactions with 212 supplements in our database — Gotu Kola is not one of them. The Mirtazapine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gotu Kola monograph Uses, safety profile, and every drug interaction in one place Mirtazapine drug information The full plain-English guide to this medication Mirtazapine supplement interactions Every supplement checked against Mirtazapine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mirtazapine and Gotu Kola?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.