Drug & supplement interaction

Groundsel + Amylase, Lipase, Protease

Amylase, Lipase, Protease brand names: Pangestyme MT 16, Pangestyme CN 10, Pangestyme CN 20, Pangestyme EC, Pangestyme UL 12, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Groundsel and Amylase, Lipase, Protease in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Groundsel and Amylase, Lipase, Protease

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amylase, Lipase, Protease and Groundsel in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Groundsel safety at a glance

Groundsel overall Avoid Groundsel contains liver-toxic pyrrolizidine alkaloids and is generally considered unsafe to ingest.
Pregnancy Likely Unsafe When used orally. Groundsel products can contain pyrrolizidine alkaloid (PA) constituents, which might be teratogenic and hepatotoxic. There is insufficient rel... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic PA constituents in groundsel are excreted in milk. There is insufficient reliable information available about the safety of using... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amylase, Lipase, Protease and Groundsel? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Amylase, Lipase, Protease

Interactions in our licensed database are recorded against drug classes, not just single drug names. Amylase, Lipase, Protease is filed under a single classification — oral drugs. Groundsel has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Amylase, Lipase, Protease’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Groundsel Does Interact With Other Medications

Groundsel has 87 moderate known drug interactions in our database — Amylase, Lipase, Protease isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Amylase, Lipase, Protease)
Taking anything else?

Check Another of Your Medications Against Groundsel

Covers the 2,830 medications we’ve checked against Groundsel. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Groundsel and Amylase, Lipase, Protease May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Groundsel

    “Orally, groundsel may cause hepatotoxicity due to its pyrrolizidine alkaloid (PA) constituents. Chronic exposure hepatotoxic PAs is associated with veno-occlusive disease. Subacute veno-occlusive disease causes vague symptoms with persistent liver enlargement. Symptoms of acute veno-occlusive disease include colicky pains in epigastrium, vomiting and diarrhea, and ascites formation within several days.”

    Groundsel · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    3. 5606. Fox DW, Hart MC, Bergeson PS, et al. Pyrrolizidine (Senecio) intoxication mimicking Reye syndrome. J Pediatr 1978;93:980-2. PubMed
    4. 3484. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed

    Amylase, Lipase, Protease

    Listed in the ADVERSE REACTIONS section of the FDA label for Amylase, Lipase, Protease. Read the label on DailyMed ›

Reported for Groundsel but not commonly for Amylase, Lipase, Protease: liver problems, raised blood pressure and vomiting.

Effects for Amylase, Lipase, Protease come from the ADVERSE REACTIONS section of its FDA label; effects for Groundsel come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Groundsel in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Groundsel products can contain pyrrolizidine alkaloid (PA) constituents, which might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of using groundsel products that do not contain hepatotoxic PAs during pregnancy. However, dietary supplements sold in the US are not required to include the amount of PAs they contain; therefore, all preparations used orally containing groundsel should be considered likely unsafe.

Lactation Likely Unsafe

When used orally. Hepatotoxic PA constituents in groundsel are excreted in milk. There is insufficient reliable information available about the safety of using groundsel products that do not contain hepatotoxic PAs during lactation. However, dietary supplements sold in the US are not required to include the amount of PAs they contain; therefore, all preparations used orally containing groundsel should be considered likely unsafe.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Amylase, Lipase, Protease

This page covers Groundsel only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amylase, Lipase, Protease page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Amylase, Lipase, Protease page

“Pancreatic enzyme replacements (amylase, lipase, and protease, the Pangestyme brands) only work if the capsules reach your gut and mix with food, and all 17 supplements listed here can interfere with that, so the list deserves real care. Activated charcoal is the one major-rated entry; it soaks up medicines in the digestive tract befor…”

Reviewed by 2 · Jul 18, 2026

Open the Amylase, Lipase, Protease interaction page

How much people look this up

Where Groundsel and Amylase, Lipase, Protease Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Groundsel
Steady interest

#1,105 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amylase, Lipase, Protease
Steady interest

#1,660 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Groundsel reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Groundsel and Amylase, Lipase, Protease records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Groundsel

What is Groundsel?

  • Menstrual complaints
  • Digestive upset
  • Minor wounds (topical)
  • Sore gums or mouth
  • Mild aches

Groundsel is a common weed traditionally used as a folk remedy, but it contains pyrrolizidine alkaloids that can cause serious liver damage. There is no reliable evidence that it works for any condition, and most health authorities consider it unsafe to take internally. We do not recommend using it.

Senecio vulgaris · Asteraceae · Aerial parts (leaves, stems, flowers) · Tea, dried herb, tincture, topical poultice

An interaction check asks whether these two react with each other — it does not ask whether Groundsel is a good idea for someone in your situation. Here is what our Groundsel record says about it on its own.

Groundsel: dosing

There is no established safe dose for groundsel. Because of its toxic pyrrolizidine alkaloids, no standardized, tested dosing exists, and we do not recommend taking it internally.If you come across a product that contains groundsel, do not assume any amount is safe.

From our Groundsel monograph — the full record covers uses, side effects and every documented interaction.

Read the full Groundsel monograph & all interactions
Medication

About Pancrelipase

What Is Pancrelipase Used For?

Brand names: Pangestyme MT 16, Pangestyme CN 10, Pangestyme CN 20, Pangestyme EC, Pangestyme UL 12, Pangestyme UL 18, Pangestyme UL 20, Pancrelipase, Pancrelipase 10,000, Lipram 10,000, Pancrecarb Ms-4, Ku-Zyme, Kutrase, Digepepsin, Pancrecarb Ms-8, Pancrelipase 16,000, Pancrelipase 20,000, Pancron 20, Festal II, Microspheres, Zymase, Entozyme, Ku-Zyme HP, Protilase, Ilozyme, Plaretase, Ultresa

Pancrelipase is used to treat exocrine pancreatic insufficiency (EPI) — a condition where the pancreas doesn't produce enough digestive enzymes. Without these enzymes, the body struggles to break down and absorb nutrients from food.

It is indicated for adults with EPI caused by chronic pancreatitis (long-term pancreas inflammation) or pancreatectomy (surgical removal of the pancreas, in whole or in part). It is also used in people with cystic fibrosis who develop EPI.

See full Pancrelipase drug information
Keep checking

Other Drugs & Groundsel

Browse every other medication we’ve checked against Groundsel — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Groundsel page.

No interaction 2,742 drugs checked — show the list

We also checked Groundsel against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Groundsel list.

See the full Groundsel interactions page
See every supplement checked against Amylase, Lipase, Protease, ranked by severity
Evidence & sources

Groundsel References

The 6 references that drive our Groundsel monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Fox DW, Hart MC, Bergeson PS, et al. Pyrrolizidine (Senecio) intoxication mimicking Reye syndrome. J Pediatr 1978;93:980-2. PubMed
  4. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  5. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  6. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Groundsel and Amylase, Lipase, Protease Together: Common Questions

Is it safe to take Groundsel with Amylase, Lipase, Protease?
We do not list a known interaction between Groundsel and Amylase, Lipase, Protease. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Groundsel and Amylase, Lipase, Protease have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Groundsel and Amylase, Lipase, Protease combination checked?
Interactions in our licensed database are recorded against drug classes. Amylase, Lipase, Protease is filed under 1 classification, and Groundsel has documented interactions with 1 drug class — none of Amylase, Lipase, Protease's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Groundsel interact with any other medications?
Yes. Groundsel has 87 documented drug interactions in our database — Amylase, Lipase, Protease is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Amylase, Lipase, Protease interact with any supplements?
Yes. Amylase, Lipase, Protease has documented interactions with 17 supplements in our database — Groundsel is not one of them. The Amylase, Lipase, Protease interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Groundsel monograph Uses, safety profile, and every drug interaction in one place Pancrelipase drug information The full plain-English guide to this medication Amylase, Lipase, Protease supplement interactions Every supplement checked against Amylase, Lipase, Protease, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amylase, Lipase, Protease and Groundsel?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.