Drug & supplement interaction

Higenamine + Ferric Citrate

Ferric Citrate brand name: Auryxia.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Higenamine and Ferric Citrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Ferric Citrate states a food rule worth keeping to.

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Interaction report

Higenamine and Ferric Citrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ferric Citrate and Higenamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Higenamine safety at a glance

Higenamine overall Use caution It acts as a stimulant on the heart and is banned in competitive sports, so it should be used with caution if at all.
Pregnancy Avoid There is no safety data in pregnancy, so it should be avoided.
Breastfeeding Avoid There is no safety data during breastfeeding, so it should be avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ferric Citrate and Higenamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ferric Citrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ferric Citrate is filed under a single classification — oral drugs. Higenamine has documented interactions with 5 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 2d6 (cyp2d6) substrates (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Ferric Citrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Higenamine Does Interact With Other Medications

Higenamine has 891 moderate known drug interactions in our database — Ferric Citrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 891 No known interaction 1,939 (incl. Ferric Citrate)
Taking anything else?

Check Another of Your Medications Against Higenamine

Covers the 2,830 medications we’ve checked against Higenamine. Pick one to open its full report.

What to actually watch for

What Higenamine Itself Has Been Linked To

This is not an interaction — nothing below involves Ferric Citrate. It is the side-effect record for Higenamine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Higenamine, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Severe muscle breakdown Worth acting on Additional detail

    “Orally, higenamine might cause rhabdomyolysis. In a case report, a 22-year-old active duty male experienced paraspinal rhabdomyolysis after consuming higenamine-containing supplement (JACK3D micro) at 150% the recommended dose and performing heavy exercise shortly after consumption. Renal function returned to normal after a couple of days; however, severe muscle pain improved only after 3 months.”

    Higenamine · Natural Medicines adverse-effect record, reported in muscle breakdown.

    1 source cited
    1. 95551. Jeter J, DeZee KJ, Kennedy L. A Case of Paraspinal Muscle Rhabdomyolysis in a 22-Year-Old Male After Ingesting a Supplement Containing Higenamine. Mil Med. 2015;180(7):e847-9. PubMed
  • An irregular heartbeat / Chest pain Worth acting on Additional detail

    “Orally, the safety of higenamine has not been studied in high-quality clinical trials. However, higenamine has been shown to have cardiac stimulant effects due to its effect on beta2-adrenoreceptors. In animal models, it appears to significantly increase heart rate; however, it does not appear to increase blood pressure. Higenamine is one of the primary cardioactive constituents in aconite.”

    Higenamine · Natural Medicines adverse-effect record, reported in irregular heartbeat.

    6 sources cited
    1. 18027. Zhang Z, Liu X, Tao Z, et al. Effects of higeramine on hemodynamics and its tolerability and safety, an experimental study. Zhonghua Yi Xue Za Zhi 2002;82:352-5.
    2. 559. Tai YT, But PP, Young K, et al. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 1992;340:1254-6. PubMed
    3. 3490. But PP, Tai YT, Young K. Three fatal cases of herbal aconite poisoning. Vet Hum Toxicol 1994;36:212-5.
    4. 15499. Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 2004;43:574-9. PubMed
    5. 95552. Zhang N, Lian Z, Peng X, Li Z, Zhu H. Applications of Higenamine in pharmacology and medicine. J Ethnopharmacol. 2017;196:242-252. PubMed
    6. 97577. Cohen PA, Travis JC, Keizers PHJ, Boyer FE, Venhuis BJ. The stimulant higenamine in weight loss and sports supplements. Clin Toxicol (Phila). 2018:1-6. PubMed
  • Shortness of breath Worth acting on Additional detail

    Recorded for Higenamine in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

  • A fast or pounding heartbeat Additional detail

    Recorded for Higenamine in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

  • Muscle pain Additional detail

    Recorded for Higenamine in the same Natural Medicines adverse-effect record shown under Severe muscle breakdown above.

  • Dizziness / Headache Additional detail

    “Orally, higenamine may cause headache.

    Intravenously, higenamine may cause dizziness and headache.”

    Higenamine · Natural Medicines adverse-effect record, reported in cluster headache.

    2 sources cited
    1. 107431. Rasic JS, Ivanovic ND, Andjelkovic MS, et al. Influence of higenamine on exercise performance of recreational female athletes: a randomized double-blinded placebo-controlled trial. Front Psychol 2021;12:633110. PubMed
    2. 97577. Cohen PA, Travis JC, Keizers PHJ, Boyer FE, Venhuis BJ. The stimulant higenamine in weight loss and sports supplements. Clin Toxicol (Phila). 2018:1-6. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Higenamine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Ferric Citrate’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Ferric Citrate column appears here.

How to take them

Some Ferric Citrate Products Have a Food Rule — Higenamine Should Not Break It

At least one FDA label for a product containing Ferric Citrate says to take it with food. If you take Higenamine on an empty stomach out of habit, keep them separate — and take Ferric Citrate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Ferric Citrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 ) 2.1 Dosage for Hyperphosphatemia in Chronic Kidney Disease on Dialysis The recommended starting dose is 2 tablets, swallowed whole, 3 times per day with meals.

From the Dosage and Administration section of the FDA label we read for Ferric Citrate — where that label names a specific product, the instruction is that product's. See the Ferric Citrate drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Ferric Citrate

This page covers Higenamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ferric Citrate page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Ferric Citrate page

“Ferric citrate (Auryxia) does its work in the gut, binding dietary phosphate in kidney disease or supplying iron, and all 17 supplements on this list can interfere with how oral medicines get absorbed. That is worth real caution, starting with the single major-rated entry, activated charcoal, which adsorbs many drugs directly and can m…”

Reviewed by 2 · Jul 18, 2026

Open the Ferric Citrate interaction page

One more smart check

Taking Higenamine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 154 real supplement products containing Higenamine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Higenamine. Even though Higenamine itself has no known interaction with Ferric Citrate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Higenamine and Ferric Citrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Higenamine
Top 25%

#328 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ferric Citrate
Steady interest

#2,012 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Higenamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Higenamine and Ferric Citrate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Higenamine

What is Higenamine?

  • Weight loss and fat burning
  • Pre-workout energy and performance
  • Appetite suppression
  • Athletic stimulant
  • Traditional medicine remedies

Higenamine is a plant-based stimulant compound added to many weight-loss and pre-workout supplements, but there is very little human evidence that it works and real concerns about heart and blood pressure effects. It is banned in sports by the World Anti-Doping Agency (WADA), and product labels often list inaccurate amounts, so most people should approach it with caution and talk to a pharmacist or doctor first.

Plant-derived alkaloid (found in plants such as Aconitum, Nelumbo/lotus, and Annona species) · Capsules, tablets, powders, pre-workout and fat-burner blends

An interaction check asks whether these two react with each other — it does not ask whether Higenamine is a good idea for someone in your situation. Here is what our Higenamine record says about it on its own.

Higenamine: dosing

There is no established or proven safe dose of higenamine. Supplement products vary widely, and testing has shown that the labeled amount is often unreliable, so it is hard to know how much you are actually taking.Because of this uncertainty and the potential heart effects, we do not recommend a specific dose.

From our Higenamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Higenamine monograph & all interactions
Medication

About Ferric Citrate

What Is Ferric Citrate Used For?

Brand name: Auryxia

Ferric citrate tablets — sold as Auryxia and under the generic name Ferric Citrate — are approved for two related uses in adults with chronic kidney disease (CKD).

For patients on dialysis, they work as a phosphate binder to control high phosphorus (hyperphosphatemia) levels in the blood. For patients with CKD who are not on dialysis, they serve as an iron replacement to treat iron deficiency anemia.

Most-Reported Side Effects for Ferric Citrate

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 307 reports
Serum ferritin increased 228 reports
Transferrin saturation increased 169 reports
Faeces discoloured 118 reports
Constipation 83 reports
See full Ferric Citrate drug information
Keep checking

Other Drugs & Higenamine

Browse every other medication we’ve checked against Higenamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
891Moderate
0Minor
1,938No known interaction
891 Moderate 1,938 No interaction
Moderate

891 interactions

Showing 60 of 891 moderate interactions — see all 891 on the Higenamine page.

No interaction 1,938 drugs checked — show the list

We also checked Higenamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,938 medications checked with no known interaction — see the full Higenamine list.

See the full Higenamine interactions page
See every supplement checked against Ferric Citrate, ranked by severity
Evidence & sources

Higenamine References

The 14 references that drive our Higenamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tai YT, But PP, Young K, et al. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 1992;340:1254-6. PubMed
  2. But PP, Tai YT, Young K. Three fatal cases of herbal aconite poisoning. Vet Hum Toxicol 1994;36:212-5.
  3. Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 2004;43:574-9. PubMed
  4. Wagner H, Reiter M, Ferstl W. New drugs with cardiotonic activity. Part 1. Chemistry and pharmacology of the cardiotonic active principle of Annona squamosa L. Planta Med 1980;40:77-85.
  5. Park CW, Chang KC, Lim JK. Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther 1984;267:279-88.
  6. Liu WH, Zhou YP, Zeng GY. Effects of dl-demethylcoclaurine on experimental heart failure. Acta Pharm Sinica 1988;23:81-5.
  7. Yun-Choi HS, Pyo MK, Park KM, et al. Anti-thrombotic effects of higenamine. Planta Med 2001;67:619-22. PubMed
  8. Zhang Z, Liu X, Tao Z, et al. Effects of higeramine on hemodynamics and its tolerability and safety, an experimental study. Zhonghua Yi Xue Za Zhi 2002;82:352-5.
  9. Kam SC, Do JM, Choi JH, et al. The relaxation effect and mechanism of action of higenamine in the rat corpus cavernosum. Int J Impot Res 2012;24:77-83. PubMed
  10. Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. PubMed
  11. Jeter J, DeZee KJ, Kennedy L. A Case of Paraspinal Muscle Rhabdomyolysis in a 22-Year-Old Male After Ingesting a Supplement Containing Higenamine. Mil Med. 2015;180(7):e847-9. PubMed
  12. Zhang N, Lian Z, Peng X, Li Z, Zhu H. Applications of Higenamine in pharmacology and medicine. J Ethnopharmacol. 2017;196:242-252. PubMed
  13. Cohen PA, Travis JC, Keizers PHJ, Boyer FE, Venhuis BJ. The stimulant higenamine in weight loss and sports supplements. Clin Toxicol (Phila). 2018:1-6. PubMed
  14. Rasic JS, Ivanovic ND, Andjelkovic MS, et al. Influence of higenamine on exercise performance of recreational female athletes: a randomized double-blinded placebo-controlled trial. Front Psychol 2021;12:633110. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Higenamine and Ferric Citrate Together: Common Questions

Is it safe to take Higenamine with Ferric Citrate?
We do not list a known interaction between Higenamine and Ferric Citrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Higenamine and Ferric Citrate at the same time of day?
At least one FDA label for a product containing Ferric Citrate says to take it with food. If you take Higenamine on an empty stomach out of habit, keep them separate and take Ferric Citrate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Ferric Citrate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Higenamine and Ferric Citrate combination checked?
Interactions in our licensed database are recorded against drug classes. Ferric Citrate is filed under 1 classification, and Higenamine has documented interactions with 5 drug classes — none of Ferric Citrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Higenamine interact with any other medications?
Yes. Higenamine has 891 documented drug interactions in our database — Ferric Citrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ferric Citrate interact with any supplements?
Yes. Ferric Citrate has documented interactions with 17 supplements in our database — Higenamine is not one of them. The Ferric Citrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Higenamine monograph Uses, safety profile, and every drug interaction in one place Ferric Citrate drug information The full plain-English guide to this medication Ferric Citrate supplement interactions Every supplement checked against Ferric Citrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ferric Citrate and Higenamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.