Drug & supplement interaction

Hu Zhang + Lansoprazole

Lansoprazole brand name: Prevacid.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Lansoprazole falls into 2 drug categories that Hu Zhang can interact with; the most serious is rated moderate. Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Hu Zhang and Lansoprazole

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Hu Zhang interacts with whole categories of medication. Lansoprazole falls into 2 of those categories, so it can interact with Hu Zhang in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES

1 of 2

Why this applies to Lansoprazole

Lansoprazole falls under CYTOCHROME P450 2C19 (CYP2C19) SUBSTRATES — the group Hu Zhang interacts with.

Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the basic idea with Prevacid (lansoprazole). Your body relies on a liver enzyme called CYP2C19 to clear this medication out. Hu Zhang is rich in resveratrol, and in test-tube studies resveratrol appears to slow that same enzyme down. If it does the same thing in people, lansoprazole could hang around a bit longer and build up slightly, which might mean a touch more of the usual side effects like headache, diarrhea, nausea, or stomach upset.

I want to be honest, though: this is theoretical. It comes from lab work, not from real-world reports in patients, and lansoprazole is generally a forgiving, well-tolerated drug. Small food amounts are unlikely to matter, but concentrated supplements are a different story. Just check with your pharmacist or doctor before pairing the two.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

2 of 2

Lansoprazole also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.

Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thinking on this pair. Hu Zhang is packed with resveratrol, and in test-tube studies resveratrol can gently block CYP3A4, one of the liver enzymes that helps clear lansoprazole (Prevacid). If that enzyme slows down, a bit more lansoprazole could linger in your body. In practice that might mean slightly stronger or longer-lasting effects, like occasional headache, stomach upset, or diarrhea, though lansoprazole is generally pretty forgiving.

The good news: this is theoretical, based on lab work, not real-world problems. A human study using a hefty resveratrol dose didn't require changing any CYP3A4 medications. Lansoprazole is not a prodrug, so we're not worried about it failing to work. Food amounts wouldn't matter, but if you're using concentrated Hu Zhang supplements, just give your pharmacist a heads-up.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  2. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  3. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Hu Zhang Also Interacts With Other Medications

Hu Zhang has 827 moderate known drug interactions in our database — the Lansoprazole one above is among them. If you take anything else, check it against the full list below.

Moderate 827 No known interaction 2,003 (incl. Lansoprazole)
Taking anything else?

Check Another of Your Medications Against Hu Zhang

Covers the 2,830 medications we’ve checked against Hu Zhang. Pick one to open its full report.

From our Q&A

Questions About Hu Zhang or Lansoprazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Hu Zhang or Lansoprazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lansoprazole

This page covers Hu Zhang only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lansoprazole page lists 153 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 101 moderate · 49 minor.

From our pharmacist’s overview on the Lansoprazole page

“Heartburn and reflux send plenty of people toward both lansoprazole (Prevacid) and the supplement aisle, and that pairing calls for genuine care, since three of the 153 ingredients on file here carry major-rated interactions. Most of the list works through the liver enzymes that clear lansoprazole, either slowing them down (grapefruit,…”

Reviewed by 2 · Jul 18, 2026

Open the Lansoprazole interaction page

One more smart check

Taking Hu Zhang as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,014 real supplement products containing Hu Zhang, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hu Zhang. Your product may carry other ingredients that interact with Lansoprazole too, on top of Hu Zhang — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hu Zhang and Lansoprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hu Zhang
Top 25%

#224 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lansoprazole
Top half

#1,325 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Hu Zhang

What is Hu Zhang?

  • Source of resveratrol
  • Heart and circulation support
  • Inflammation
  • Liver and digestive complaints (traditional)
  • Cough and respiratory symptoms (traditional)
  • Skin and joint conditions (traditional topical use)

Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for inflammation and heart health, but high-quality evidence in people is limited. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Hu Zhang monograph & all interactions
Medication

About Lansoprazole

What Is Lansoprazole Used For?

Brand name: Prevacid

Lansoprazole lowers stomach acid. Prescription products are used for ulcers in the first part of the small intestine (duodenal ulcers) and in the stomach, for gastroesophageal reflux disease (GERD), and for erosive esophagitis (damage to the esophagus lining from acid).

It is also used with antibiotics to clear H. pylori infection, and for conditions where the stomach makes too much acid, such as Zollinger-Ellison syndrome. Certain over-the-counter lansoprazole capsules (such as Prevacid 24 HR) and tablets treat frequent heartburn, meaning heartburn on 2 or more days a week.

See full Lansoprazole drug information Lansoprazole NDC codes and packages
Keep checking

Other Drugs & Hu Zhang

Browse every other medication we’ve checked against Hu Zhang — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
827Moderate
0Minor
2,002No known interaction
827 Moderate 2,002 No interaction
Moderate

827 interactions

Showing 60 of 827 moderate interactions — see all 827 on the Hu Zhang page.

No interaction 2,002 drugs checked — show the list

We also checked Hu Zhang against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,002 medications checked with no known interaction — see the full Hu Zhang list.

See the full Hu Zhang interactions page
See every supplement checked against Lansoprazole, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Hu Zhang monograph › Uses, safety, and every drug interaction in one place Lansoprazole supplement interactions › Every supplement checked against Lansoprazole, ranked by severity Lansoprazole drug information › The full plain-English guide to this medication Lansoprazole NDC codes and packages › Every package, labeler and price in the FDA directory Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Hu Zhang and Lansoprazole Together: Common Questions

Can you take Hu Zhang with Lansoprazole?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Hu Zhang and Lansoprazole?
Lansoprazole belongs to more than one drug category, and Hu Zhang interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Hu Zhang and Lansoprazole interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Lansoprazole and Hu Zhang?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.