Drug & supplement interaction

Ipriflavone + Levonorgestrel

Levonorgestrel brand names: Plan B, Mirena, Levonelle One Step, Levonelle 1500, Norgeston, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Ipriflavone and Levonorgestrel in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Ipriflavone and Levonorgestrel

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Levonorgestrel and Ipriflavone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ipriflavone safety at a glance

Ipriflavone overall Use caution May lower white blood cell counts and has limited long-term safety data.
Pregnancy Avoid Not enough safety data and possible estrogen-like effects; avoid use.
Breastfeeding Avoid No reliable safety information during breastfeeding; best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Levonorgestrel and Ipriflavone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Levonorgestrel

Interactions in our licensed database are recorded against drug classes, not just single drug names. Levonorgestrel is filed under 6 classifications — including contraceptive drugs, cytochrome p450 1a2 (cyp1a2) inhibitors, topical drugs. Ipriflavone has documented interactions with 4 drug classes — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (moderate), cytochrome p450 2c9 (cyp2c9) substrates (moderate) and immunosuppressants (moderate) — and none of Levonorgestrel’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ipriflavone Does Interact With Other Medications

Ipriflavone has 392 moderate known drug interactions in our database — Levonorgestrel isn’t one of them. If you take anything else, check it against the full list below.

Moderate 392 No known interaction 2,438 (incl. Levonorgestrel)
Taking anything else?

Check Another of Your Medications Against Ipriflavone

Covers the 2,830 medications we’ve checked against Ipriflavone. Pick one to open its full report.

What to actually watch for

What Ipriflavone Itself Has Been Linked To

This is not an interaction — nothing below involves Levonorgestrel. It is the side-effect record for Ipriflavone on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ipriflavone, this list is the first place to look.

  • Dizziness Additional detail

    “Orally, ipriflavone is generally well-tolerated. However, some patients taking ipriflavone can experience epigastric pain, diarrhea, and dizziness. There is some concern that ipriflavone can cause lymphocytopenia when used for at least 6 months.”

    Ipriflavone · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 432. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
    2. 104208. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed
    3. 1196. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  • Diarrhea Additional detail

    “Orally, ipriflavone can cause epigastric pain and diarrhea in some people.”

    Ipriflavone · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 432. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
    2. 104208. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Ipriflavone — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Levonorgestrel’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Levonorgestrel column appears here.

From our Q&A

Questions About Ipriflavone or Levonorgestrel

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ipriflavone or Levonorgestrel, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Levonorgestrel

This page covers Ipriflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Levonorgestrel page lists 191 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 142 moderate · 43 minor.

From our pharmacist’s overview on the Levonorgestrel page

“St. John's wort tops my worry list for anyone using levonorgestrel (Plan B, Mirena, and other birth control).”

Reviewed by 2 · Jul 18, 2026

Open the Levonorgestrel interaction page

One more smart check

Taking Ipriflavone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 204 real supplement products containing Ipriflavone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ipriflavone. Even though Ipriflavone itself has no known interaction with Levonorgestrel, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ipriflavone and Levonorgestrel Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ipriflavone
Top half

#478 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Levonorgestrel
Top 25%

#617 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ipriflavone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Ipriflavone and Levonorgestrel records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ipriflavone

What is Ipriflavone?

Ipriflavone
  • Bone density and osteoporosis
  • Postmenopausal bone loss
  • Athletic performance
  • Tinnitus related to bone disorders

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Because it can lower white blood cell counts in some people and its long-term safety is not well established, talk with your pharmacist or doctor before using it.

Synthetic compound (a semi-synthetic isoflavone derived from soy isoflavones) · Tablets, capsules

An interaction check asks whether these two react with each other — it does not ask whether Ipriflavone is a good idea for someone in your situation. Here is what our Ipriflavone record says about it on its own.

Ipriflavone: dosing

There is no officially established or universally agreed dietary supplement dose for ipriflavone. Doses used in research were studied for osteoporosis and are not a recommendation for general use.If you choose to use a product, follow the directions on the label and do not exceed them. People considering it for bone health should also discuss adequate calcium and vitamin D intake.

From our Ipriflavone monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ipriflavone monograph & all interactions
Medication

About Levonorgestrel

What Is Levonorgestrel Used For?

Brand names: Plan B, Mirena, Levonelle One Step, Levonelle 1500, Norgeston, Skyla, Liletta, Kyleena

Levonorgestrel is used in two very different ways, depending on the product.

The intrauterine systems (Mirena, Liletta, Kyleena and Skyla) prevent pregnancy for a set number of years. Mirena and Liletta are also used to treat heavy menstrual bleeding in women who choose intrauterine contraception. The oral tablets are used for emergency contraception, to reduce the chance of pregnancy after unprotected sex.

Most-Reported Side Effects for Levonorgestrel

From FAERS, the FDA’s public side-effect reporting system (206,325 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Device expulsion 45,536 reports
Device dislocation 20,447 reports
Menstruation irregular 15,061 reports
Vaginal haemorrhage 15,056 reports
Genital haemorrhage 11,164 reports
See full Levonorgestrel drug information
Keep checking

Other Drugs & Ipriflavone

Browse every other medication we’ve checked against Ipriflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
392Moderate
0Minor
2,437No known interaction
392 Moderate 2,437 No interaction
Moderate

392 interactions

Showing 60 of 392 moderate interactions — see all 392 on the Ipriflavone page.

No interaction 2,437 drugs checked — show the list

We also checked Ipriflavone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,437 medications checked with no known interaction — see the full Ipriflavone list.

See the full Ipriflavone interactions page
See every supplement checked against Levonorgestrel, ranked by severity
Evidence & sources

Ipriflavone References

The 6 references that drive our Ipriflavone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
  2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  3. Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
  4. Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
  5. Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
  6. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ipriflavone and Levonorgestrel Together: Common Questions

Is it safe to take Ipriflavone with Levonorgestrel?
We do not list a known interaction between Ipriflavone and Levonorgestrel. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Ipriflavone and Levonorgestrel combination checked?
Interactions in our licensed database are recorded against drug classes. Levonorgestrel is filed under 6 classifications, and Ipriflavone has documented interactions with 4 drug classes — none of Levonorgestrel's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ipriflavone interact with any other medications?
Yes. Ipriflavone has 392 documented drug interactions in our database — Levonorgestrel is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Levonorgestrel interact with any supplements?
Yes. Levonorgestrel has documented interactions with 191 supplements in our database — Ipriflavone is not one of them. The Levonorgestrel interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ipriflavone monograph Uses, safety profile, and every drug interaction in one place Levonorgestrel drug information The full plain-English guide to this medication Levonorgestrel supplement interactions Every supplement checked against Levonorgestrel, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Levonorgestrel and Ipriflavone?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.