Drug & supplement interaction

Kratom + Diclofenac Sodium

Diclofenac Sodium brand names: Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, and others.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Kratom and Diclofenac Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Kratom and Diclofenac Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diclofenac Sodium and Kratom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Kratom safety at a glance

Kratom overall Avoid Kratom carries risks of dependence, serious side effects, and contaminated products, and is not regulated as a safe supplement.

Pregnancy Possibly Unsafe When used orally. There have been multiple case reports of neonatal abstinence syndrome in the infants of those who used kratom during pregnancy. Animal researc... Read the full pregnancy detail

Breastfeeding Avoid Kratom compounds may pass into breast milk and should be avoided while nursing.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diclofenac Sodium and Kratom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Diclofenac Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diclofenac Sodium is filed under 11 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Kratom has documented interactions with 11 drug classes — the most serious being cns depressants (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 2d6 (cyp2d6) substrates (moderate) — and none of Diclofenac Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Kratom Does Interact With Other Medications

Kratom has 983 moderate, 12 minor known drug interactions in our database — Diclofenac Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 983 Minor 12 No known interaction 1,835 (incl. Diclofenac Sodium)

Taking anything else?

Check Another of Your Medications Against Kratom

Covers the 2,830 medications we’ve checked against Kratom. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Kratom and Diclofenac Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 9 of them are worth acting on rather than waiting out — marked below.

High potassium Worth acting on Additional detail
Kratom
“Orally, kratom has been associated with frequent urination, electrolyte abnormalities, and renal insufficiency,. In one case report, a 61-year-old male with no significant past medical history experienced persistent asymptomatic hyperkalemia after 4 months of regular, nearly daily use of kratom. Potassium levels normalized upon discontinuation of kratom.”

Kratom · Natural Medicines adverse-effect record, reported in nausea and vomiting.
6 sources cited

27130. Jansen KL, Prast CJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. J Ethnopharmacol 1988;23(1):115-119. PubMed

27136. US Food and Drug Administration (2014). SNI National is Voluntarily recalling Kratom XL 4 Pack, Maeng Da Kratom 10 Pack, Max Kratom 20 Pack, and Bali Kratom 40 pack Due to Undeclared Drug Ingredients [Press Release].

95797. Castillo A, Payne JD, Nugent K. Posterior reversible leukoencephalopathy syndrome after kratom ingestion. Proc (Bayl Univ Med Cent). 2017;30(3):355-357. PubMed

108762. Torres-Ortiz A, Al Zein S, Alqudsi M. A Case of Hyperkalemia Induced by Kratom (Mitragyna speciosa). Cureus 2022;14(4):e24036. PubMed

113066. LeSaint KT, Yin S, Sharma A, Avery BA, McCurdy CR, Waksman JC. Acute Renal Insufficiency Associated With Consumption of Hydrocodone- and Morphine-Adulterated Kratom (Mitragyna Speciosa). J Emerg Med 2022;63(1):e28-e30. PubMed

113068. Martin G, Collins DP, Valenzuela H. Life-Threatening Hyponatremia Secondary to Chronic Kratom Use: A Case Presentation. Cureus 2022;14(9):e29073. PubMed
Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Yellowing of the skin or eyes Worth acting on Additional detail
Kratom
“Orally, kratom has been associated with cases of liver damage. Between 2003 and 2019, there were 11 cases of liver injury reported in the Drug-Induced Liver Injury Network (DILIN) with definite, highly likely, or probable causality attributed to kratom. Of these cases, 8 were reported between 2017 and 2019. The median time from kratom use to the onset of symptoms was 14 days.”

Kratom · Natural Medicines adverse-effect record, reported in alcohol-related liver disease.
6 sources cited

104634. Ahmad J, Odin JA, Hayashi PH, et al. Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature. Drug Alcohol Depend. 2021;218:108426. PubMed

103216. Schimmel J, Dart RC. Kratom (Mitragyna speciosa) liver injury: a comprehensive review. Drugs. 2020;80(3):263-83. PubMed

113075. Reich N, Salvo G, Leong D, Wan V, Kosatsky T. Kratom exposures managed by the British Columbia poison centre, 2012-2019: a descriptive analysis. CMAJ Open 2022;10(3):E755-E761. PubMed

27133. Kapp FG, Maurer HH, Auwarter V, Winkelmann M, Hermanns-Clausen M. Intrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa). J Med Toxicol 2011;7(3):227-231. PubMed

95798. Cumpston KL, Carter M, Wills BK. Clinical outcomes after Kratom exposures: A poison center case series. Am J Emerg Med. 2018;36(1):166-168. PubMed

101703. Aldyab M, Ells PF, Bui R, Chapman TD, Lee H. Kratom-Induced Cholestatic Liver Injury Mimicking Anti-Mitochondrial Antibody-Negative Primary Biliary Cholangitis: A Case Report and Review of Literature. Gastroenterology Res. 2019 Aug;12(4):211-215. PubMed
Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Confusion Worth acting on Additional detail
Kratom
“In one Poison Control Center report of 3484 exposures to kratom, the majority of which involved oral single-substance exposures, 75% of cases reported neurologic effects, including agitation, coma, confusion, dizziness, drowsiness, hallucinations, seizures, and tremor.”

Kratom · Natural Medicines adverse-effect record, reported in alcohol-related liver disease.
6 sources cited

108565. Graves JM, Dilley JA, Terpak L, et al. Kratom exposures among older adults reported to U.S. poison centers, 2014-2019. J Am Geriatr Soc 2021;69(8):2176-2184. PubMed

95798. Cumpston KL, Carter M, Wills BK. Clinical outcomes after Kratom exposures: A poison center case series. Am J Emerg Med. 2018;36(1):166-168. PubMed

101707. Eggleston W, Stoppacher R, Suen K, Marraffa JM, Nelson LS. Kratom Use and Toxicities in the United States. Pharmacotherapy. 2019 Jul;39(7):775-777. doi: 10.1002/phar.2280. Epub 2019 Jun 13. PubMed

104637. Davidson C, Cao D, King T, et al. A comparative analysis of kratom exposure cases in Thailand and the United States from 2010-2017. Am J Drug Alcohol Abuse. 2020:1-10. PubMed

113071. Peran D, Stern M, Cernohorsky P, Sykora R, Popela S, Duska F. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon 2023;225:107054. PubMed

103214. Afzal H, Esang M, Rahman S. A case of kratom-induced seizures. Cureus. 2020;12(1):e6588. PubMed
“Orally, kratom has been associated with aggression, agitation, altered mental status, anxiety, delusions, depression, hallucinations, insomnia, irritability, paranoia, restlessness, sedation, and suicidal ideation, in case reports and case series.”

Kratom · Natural Medicines adverse-effect record, reported in anxiety.
6 sources cited

27136. US Food and Drug Administration (2014). SNI National is Voluntarily recalling Kratom XL 4 Pack, Maeng Da Kratom 10 Pack, Max Kratom 20 Pack, and Bali Kratom 40 pack Due to Undeclared Drug Ingredients [Press Release].

95798. Cumpston KL, Carter M, Wills BK. Clinical outcomes after Kratom exposures: A poison center case series. Am J Emerg Med. 2018;36(1):166-168. PubMed

113067. Li X, Ndungu P, Taneja SB, et al. An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021. Clin Transl Sci 2023.

113071. Peran D, Stern M, Cernohorsky P, Sykora R, Popela S, Duska F. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon 2023;225:107054. PubMed

113079. Settle AG, Yang C. A Case of Severe Kratom Addiction Contributing to a Suicide Attempt. Cureus 2022;14(9):e29698. PubMed

113080. Smith KE, Feldman JD, Dunn KE, et al. Examining the paradoxical effects of kratom: a narrative inquiry. Front Pharmacol 2023;14:1174139. PubMed
Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Seizures Worth acting on Additional detail
Kratom
“Orally, kratom has been linked to respiratory depression, particularly when used in combination with other mu-opioid agonists. In one case report, a 36-year-old male with a history of substance abuse and smoking was diagnosed with kratom-induced acute respiratory distress syndrome (ARDS) after presenting with progressive respiratory failure, hypoxemia, and bilateral lung infiltrates.”

Kratom · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).
6 sources cited

27119. Backstrom BG, Classon G, Lowenhielm P, Thelander G. [Krypton--new, deadly Internet drug. Since October 2009 have nine young persons died in Sweden]. Lakartidningen 2010;107(50):3196-3197.

27120. Kronstrand R, Roman M, Thelander G, Eriksson A. Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton. J Anal Toxicol 2011;35(4):242-247. PubMed

27136. US Food and Drug Administration (2014). SNI National is Voluntarily recalling Kratom XL 4 Pack, Maeng Da Kratom 10 Pack, Max Kratom 20 Pack, and Bali Kratom 40 pack Due to Undeclared Drug Ingredients [Press Release].

104637. Davidson C, Cao D, King T, et al. A comparative analysis of kratom exposure cases in Thailand and the United States from 2010-2017. Am J Drug Alcohol Abuse. 2020:1-10. PubMed

108565. Graves JM, Dilley JA, Terpak L, et al. Kratom exposures among older adults reported to U.S. poison centers, 2014-2019. J Am Geriatr Soc 2021;69(8):2176-2184. PubMed

113071. Peran D, Stern M, Cernohorsky P, Sykora R, Popela S, Duska F. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon 2023;225:107054. PubMed
Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Low mood Worth acting on Additional detail

Kratom

Recorded for Kratom in the same Natural Medicines adverse-effect record shown under Seizures above.

Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Kidney problems Worth acting on Additional detail
Kratom
“Observational research has found that habitual intake of kratom is associated with withdrawal symptoms, including arthralgias, lower extremity hyperreflexia, muscle pain, rigidity, spasms, and tremors.

In a case report, a 45-year-old adult who had used kratom intermittently for 10 months experienced mild rhabdomyolysis and generalized seizures.”

Kratom · Natural Medicines adverse-effect record, reported in epilepsy.
6 sources cited

27115. Singh D, Müller CP, Vicknasingam BK. Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users. Drug Alcohol Depend 2014 Jun 1;139:132-7. PubMed

27130. Jansen KL, Prast CJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. J Ethnopharmacol 1988;23(1):115-119. PubMed

104637. Davidson C, Cao D, King T, et al. A comparative analysis of kratom exposure cases in Thailand and the United States from 2010-2017. Am J Drug Alcohol Abuse. 2020:1-10. PubMed

113061. Hong S, Zimmerman PE, Rao V, Markwalter DW. Buprenorphine-Naloxone in the Setting of Kratom Withdrawal, Opioid Use Disorder, and Stage IV Lung Adenocarcinoma. J Palliat Med 2023;26(5):734-736. PubMed

113080. Smith KE, Feldman JD, Dunn KE, et al. Examining the paradoxical effects of kratom: a narrative inquiry. Front Pharmacol 2023;14:1174139. PubMed

95798. Cumpston KL, Carter M, Wills BK. Clinical outcomes after Kratom exposures: A poison center case series. Am J Emerg Med. 2018;36(1):166-168. PubMed
Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Raised blood pressure Worth acting on Additional detail

Kratom

Recorded for Kratom in the same Natural Medicines adverse-effect record shown under Seizures above.

Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Shortness of breath Worth acting on Additional detail

Kratom

Recorded for Kratom in the same Natural Medicines adverse-effect record shown under Seizures above.

Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Liver problems Worth acting on Additional detail

Kratom

Recorded for Kratom in the same Natural Medicines adverse-effect record shown under Seizures above.

Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›
Passing urine more often Additional detail

Kratom

Recorded for Kratom in the same Natural Medicines adverse-effect record shown under Seizures above.

Diclofenac Sodium

Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac Sodium. Read the label on DailyMed ›

Showing the 10 most notable of 30 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Kratom but not commonly for Diclofenac Sodium: dependence or withdrawal symptoms, reduced appetite, increased appetite and serotonin syndrome.

Effects for Diclofenac Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Kratom come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 155,962 voluntary FDA FAERS reports for Diclofenac Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Kratom in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. There have been multiple case reports of neonatal abstinence syndrome in the infants of those who used kratom during pregnancy. Animal research suggests that kratom crosses the placenta.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Kratom or Diclofenac Sodium

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Kratom or Diclofenac Sodium, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diclofenac Sodium

This page covers Kratom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac Sodium page lists 308 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 266 moderate · 35 minor.

From our pharmacist’s overview on the Diclofenac Sodium page

“Diclofenac (Voltaren), a daily mainstay for arthritis and joint pain, comes with a supplement list that calls for real vigilance. Of the 308 ingredients on file, 7 rate major, and roughly two hundred entries share a single theme: anything with blood-thinning activity adds to diclofenac's own bleeding risk, especially in the stomach.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac Sodium interaction page

One more smart check

Taking Kratom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Kratom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kratom. Even though Kratom itself has no known interaction with Diclofenac Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Kratom and Diclofenac Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kratom

Top half

#401 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Diclofenac Sodium

Top 25%

#366 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Kratom reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Kratom and Diclofenac Sodium records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Kratom

What is Kratom?

Pain relief
Opioid withdrawal symptoms
Anxiety and stress
Low energy or fatigue
Mood enhancement

Kratom is a Southeast Asian plant whose leaves act on the brain's opioid receptors and can produce both stimulant-like and opioid-like effects. It is not approved or proven safe by health regulators, carries real risks of dependence and serious harm, and its legal status varies widely. Talk to a pharmacist or doctor before considering it.

Mitragyna speciosa · Rubiaceae · Leaves · Dried leaf powder, capsules, tablets, brewed tea, liquid extracts, and concentrated gummies

An interaction check asks whether these two react with each other — it does not ask whether Kratom is a good idea for someone in your situation. Here is what our Kratom record says about it on its own.

Kratom: dosing

There is no established safe or standardized dose for kratom. The strength of products varies widely, and the amount of active compounds can differ greatly from one batch to another, even within the same brand.Because of these unknowns and the real risks of dependence and harm, we cannot recommend a specific amount. Avoid mixing it with alcohol, opioids, sedatives, or other substances.

From our Kratom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Kratom monograph & all interactions

Medication

About Diclofenac

What Is Diclofenac Used For?

Brand names: Voltaren XR, Voltaren, Voltaren SR, Diclo, Difenac, Diclo SR, Voltarol, Acoflam, Defenac, Dicloflex, Diclovol, Diclozip, Fenactol, Flamrase, Volraman, Diclomax SR, Diclomax Retard, Motifene 75 mg, Voltarol 75 mg SR, Acoflam 75 SR, Defenac SR, Dexomon 75 SR, Dicloflex 75 SR, Diclovol SR, Fenactol 75 mg SR, Flamatak 75 MR, Flamrase SR, Flexotard MR 75, Rheumatac Retard 75, Rhumalgan CR, Slofenac SR, Volsaid Retard 75, Voltarol Retard, Acoflam Retard, Defenac Retard, Dexomon Retard 100, Dicloflex Retard, Diclovol Retard, Fenactol Retard 100 mg, Flamatak 100 MR, Volsaid Retard 100, Voltarol Ophtha Multidose, Voltarol Ophtha, Pennsaid, Voltaren Emulgel, Dyloject

Diclofenac sodium topical gel is used to treat actinic keratoses (AK) — rough, scaly skin patches that form after years of sun exposure. These patches are considered precancerous, meaning they can develop into skin cancer if left untreated.

This is a topical gel, meaning it is applied directly to the skin over the affected area rather than taken by mouth. It belongs to the NSAID (nonsteroidal anti-inflammatory drug) family.

Most-Reported Side Effects for Diclofenac Sodium

From FAERS, the FDA’s public side-effect reporting system (155,962 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 13,844 reports

Arthralgia 11,333 reports

Rash 10,855 reports

Rheumatoid arthritis 10,744 reports

Abdominal discomfort 9,636 reports

See full Diclofenac drug information

Keep checking

Other Drugs & Kratom

Browse every other medication we’ve checked against Kratom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

983Moderate

12Minor

1,834No known interaction

983 Moderate 12 Minor 1,834 No interaction

Moderate

983 interactions

Showing 60 of 983 moderate interactions — see all 983 on the Kratom page.

Minor

12 interactions

No interaction 1,834 drugs checked — show the list

We also checked Kratom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,834 medications checked with no known interaction — see the full Kratom list.

See the full Kratom interactions page

See every supplement checked against Diclofenac Sodium, ranked by severity

Evidence & sources

Kratom References

The 77 references that drive our Kratom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Singh D, Müller CP, Vicknasingam BK. Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users. Drug Alcohol Depend 2014 Jun 1;139:132-7. PubMed
Backstrom BG, Classon G, Lowenhielm P, Thelander G. [Krypton--new, deadly Internet drug. Since October 2009 have nine young persons died in Sweden]. Lakartidningen 2010;107(50):3196-3197.
Kronstrand R, Roman M, Thelander G, Eriksson A. Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton. J Anal Toxicol 2011;35(4):242-247. PubMed
Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction 2008;103(6):1048-1050.
Jansen KL, Prast CJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. J Ethnopharmacol 1988;23(1):115-119. PubMed
Nelsen JL, Lapoint J, Hodgman MJ, Aldous KM. Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure. J Med Toxicol 2010;6(4):424-426. PubMed
Sheleg SV, Collins GB. A coincidence of addiction to "Kratom" and severe primary hypothyroidism. J Addict Med 2011;5(4):300-301. PubMed
Kapp FG, Maurer HH, Auwarter V, Winkelmann M, Hermanns-Clausen M. Intrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa). J Med Toxicol 2011;7(3):227-231. PubMed
Kong WM, Chik Z, Ramachandra M, et al. Evaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay. Molecules. 2011;16(9):7344-7356. PubMed
US Food and Drug Administration (2014). SNI National is Voluntarily recalling Kratom XL 4 Pack, Maeng Da Kratom 10 Pack, Max Kratom 20 Pack, and Bali Kratom 40 pack Due to Undeclared Drug Ingredients [Press Release].
Castillo A, Payne JD, Nugent K. Posterior reversible leukoencephalopathy syndrome after kratom ingestion. Proc (Bayl Univ Med Cent). 2017;30(3):355-357. PubMed
Cumpston KL, Carter M, Wills BK. Clinical outcomes after Kratom exposures: A poison center case series. Am J Emerg Med. 2018;36(1):166-168. PubMed
FDA Adverse Event Reporting System: Kratom Deaths. February 6, 2018. https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/CDERFOIAElectronicReadingRoom/UCM595575.pdf. Accessed March 6, 2018.
Trakulsrichai S, Sathirakul K, Auparakkitanon S, et al. Pharmacokinetics of mitragynine in man. Drug Des Devel Ther. 2015;9:2421-9. PubMed
Kruegel AC, Grundmann O. The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse.Neuropharmacology. 2017. pii: S0028-3908(17)30393-3. PubMed
Singh D, Murugaiyah V, Hamid SBS, et al. Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users. J Ethnopharmacol 2018;221:30-6. doi: 10.1016/j.jep.2018.04.005. PubMed
Singh D, Müller CP, Murugaiyah V, et al. Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia. J Ethnopharmacol 2018;214:197-206. doi: 10.1016/j.jep.2017.12.017. PubMed
Olsen EO, O'Donnell J, Mattson CL, Schier JG, Wilson N. Notes from the field: Unintentional drug overdose deaths with kratom detected - 27 States, July 2016-December 2017. MMWR Morb Mortal Wkly Rep. 2019;68(14):326-327.
Hughes RL. Fatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction. Forensic Sci Med Pathol. 2019 Mar;15(1):110-113. PubMed
Gershman K, Timm K, Frank M, et al. Deaths in Colorado Attributed to Kratom. N Engl J Med. 2019 Jan 3;380(1):97-98. PubMed
Mackay L, Abrahams R. Novel case of maternal and neonatal kratom dependence and withdrawal. Can Fam Physician. 2018 Feb;64(2):121-122.
Davidson L, Rawat M, Stojanovski S, Chandrasekharan P. Natural drugs, not so natural effects: Neonatal abstinence syndrome secondary to 'kratom'. J Neonatal Perinatal Med. 2019;12(1):109-112. PubMed
Smid MC, Charles JE, Gordon AJ, Wright TE. Use of Kratom, an Opioid-like Traditional Herb, in Pregnancy. Obstet Gynecol. 2018 Oct;132(4):926-928. PubMed
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Diclofenac Sodium Is Linked to Lower Levels of One Nutrient

Natural Medicines records Diclofenac Sodium as a medicine that can lower these. This is not an interaction with Kratom — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

FOLIC ACID›

Read the full Diclofenac Sodium nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Kratom and Diclofenac Sodium Together: Common Questions

Is it safe to take Kratom with Diclofenac Sodium?

We do not list a known interaction between Kratom and Diclofenac Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Kratom and Diclofenac Sodium have any of the same side effects?

Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

How was the Kratom and Diclofenac Sodium combination checked?

Interactions in our licensed database are recorded against drug classes. Diclofenac Sodium is filed under 11 classifications, and Kratom has documented interactions with 11 drug classes — none of Diclofenac Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Kratom interact with any other medications?

Yes. Kratom has 995 documented drug interactions in our database — Diclofenac Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Diclofenac Sodium interact with any supplements?

Yes. Diclofenac Sodium has documented interactions with 308 supplements in our database — Kratom is not one of them. The Diclofenac Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Kratom monograph Uses, safety profile, and every drug interaction in one place Diclofenac drug information The full plain-English guide to this medication Diclofenac Sodium supplement interactions Every supplement checked against Diclofenac Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 77 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diclofenac Sodium and Kratom?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

case report: A written account of what happened to one patient, useful as a signal but not proof of cause.

case series: A report describing what happened to a small group of patients, with no comparison group.

abuse: Using a medicine in a way it was not meant to be used, such as taking more than prescribed to feel a high.

aggression: Hostile or violent feelings or behavior directed toward other people.

agitation: A state of feeling restless and upset and being unable to relax, sometimes with pacing or fidgeting.

agonist: A substance that switches on a specific target in the body to produce an effect, the way a key turns a lock.

anxiety: A feeling of worry, nervousness, or unease, sometimes along with a racing heart or restlessness.

cardiac arrest: A sudden stop of the heart's pumping that cuts off blood flow to the body, which is a medical emergency.

constipation: Having bowel movements less often than usual, or passing stools that are hard, dry, and difficult to move.

depression: A lasting low mood with loss of interest that affects everyday life.

Drug Interactions: The label section listing other medicines, foods, or substances that can change how a medicine works or raise the chance of side effects.

electrolyte: A mineral in the blood and body fluids, such as sodium, potassium, or calcium, that carries a small electric charge and helps the body work.

encephalopathy: Any condition that affects how the brain works, causing confusion, memory problems, or changes in alertness.

euphoria: An intense feeling of happiness or well-being that is stronger than a normal good mood.

hyperkalemia: A higher-than-normal level of potassium, an important mineral, in the blood.

hyperreflexia: Overactive or exaggerated reflexes, such as an unusually strong knee-jerk response.

hypoxemia: A lower-than-normal level of oxygen in the blood.

insomnia: Trouble falling asleep, staying asleep, or getting restful sleep.

irritability: Getting annoyed, frustrated, or angry more easily than usual.

partial agonist: A substance that switches on a body target only part way, giving a weaker effect than a full activator would.

respiratory depression: Breathing that becomes too slow or too shallow to move enough air, so the body may not get enough oxygen.

respiratory failure: A serious condition in which the lungs cannot get enough oxygen into the blood or remove enough carbon dioxide.

restlessness: An inability to stay calm or still, with a constant feeling of needing to move.

rhabdomyolysis: A serious condition where damaged muscle breaks down and releases material into the blood that can harm the kidneys.

sedation: A calm, sleepy, slowed-down state caused by a medicine that relaxes the brain and body.

suicidal ideation: Thoughts about wanting to end your own life, which can range from a passing wish to a detailed plan.

tremor: Shaking or trembling of part of the body, such as the hands, that a person cannot control.

withdrawal: Uncomfortable physical or mental symptoms that appear when a medicine the body has gotten used to is reduced or stopped.