Drug & supplement interaction

Lactiplantibacillus Pentosus + Cephapirin

Cephapirin brand name: Cefadyl.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Lactiplantibacillus Pentosus has a moderate interaction with Cephapirin. Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Lactiplantibacillus Pentosus and Cephapirin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Cephapirin

Cephapirin falls under ANTIBIOTIC DRUGS — the group Lactiplantibacillus Pentosus interacts with.

Theoretically, taking Lactiplantibacillus pentosus with antibiotic drugs might decrease the effectiveness of L. pentosus.
Lactiplantibacillus pentosus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. pentosus preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Cephapirin (Cefadyl) is an antibiotic, and antibiotics don't tell the difference between unwanted bacteria and the 'friendly' kind in your probiotic. So if you swallow your Lactiplantibacillus pentosus at the same time as your cephapirin dose, the antibiotic can kill off a good chunk of those live probiotic organisms before they ever do their job. This works against the probiotic, not your treatment, your cephapirin still fights infection just fine.

An easy fix is spacing them out. Most pharmacists suggest taking the probiotic at least two hours apart from the antibiotic. This is based on how these products work rather than hard clinical studies, so it's a sensible habit, not a worry. When in doubt, run your timing by your pharmacist.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Lactiplantibacillus Pentosus Also Interacts With Other Medications

Lactiplantibacillus Pentosus has 181 moderate known drug interactions in our database — the Cephapirin one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Cephapirin)
Taking anything else?

Check Another of Your Medications Against Lactiplantibacillus Pentosus

Covers the 2,830 medications we’ve checked against Lactiplantibacillus Pentosus. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Cephapirin

This page covers Lactiplantibacillus Pentosus only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cephapirin page lists 43 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate), Aristolochia (moderate) and Bacillus Coagulans (moderate).

By severity: 2 major · 39 moderate · 2 minor.

From our pharmacist’s overview on the Cephapirin page

“Cephapirin (Cefadyl) is an injectable antibiotic for bacterial infections, and its supplement list calls for real vigilance because of two major-rated entries, both herbs capable of injuring the kidneys on their own. Siberian cocklebur has documented kidney harm, and asarabacca is frequently contaminated with aristolochic acid, a compo…”

Reviewed by 2 · Jul 18, 2026

Open the Cephapirin interaction page

How much people look this up

Where Lactiplantibacillus Pentosus and Cephapirin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lactiplantibacillus Pentosus
Steady interest

#1,220 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cephapirin
Top half

#923 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Lactiplantibacillus Pentosus

What is Lactiplantibacillus Pentosus?

  • Digestive and gut health
  • Immune support
  • Maintaining a healthy gut microbiome
  • Fermentation of foods (such as olives and vegetables)

Lactiplantibacillus pentosus is a 'friendly' probiotic bacterium found in many fermented foods and used in some supplements for gut and immune health. Research is still early, so it is not proven to treat any specific condition. It is generally considered safe for healthy adults, but people with weakened immune systems or serious illness should talk to a doctor first.

Read the full Lactiplantibacillus Pentosus monograph & all interactions
Keep checking

Other Drugs & Lactiplantibacillus Pentosus

Browse every other medication we’ve checked against Lactiplantibacillus Pentosus — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Lactiplantibacillus Pentosus page.

No interaction 2,648 drugs checked — show the list

We also checked Lactiplantibacillus Pentosus against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Lactiplantibacillus Pentosus list.

See the full Lactiplantibacillus Pentosus interactions page
See every supplement checked against Cephapirin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Lactiplantibacillus Pentosus monograph › Uses, safety, and every drug interaction in one place Cephapirin supplement interactions › Every supplement checked against Cephapirin, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Lactiplantibacillus Pentosus and Cephapirin Together: Common Questions

Can you take Lactiplantibacillus Pentosus with Cephapirin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Lactiplantibacillus Pentosus and Cephapirin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Cephapirin and Lactiplantibacillus Pentosus?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.